A novel single-chip RF-voltage-controlled oscillator for bio-sensing applications

A novel interdigiated capacitance (IDC) based affinity biosensor system is presented that detects C-Reactive Protein (CRP), a risk marker for cardiovascular diseases, and transmit the information to a distance location wirelessly. The biosensor system consist of a voltage controlled oscillator (VCO) and an IDC. In the presence of CRP the capacitance of the IDC changes and this directly reflects to the oscillation frequency of the VCO. In the presence of 800 ng/ml antigen the frequency of the system shifts from 1.9438 GHz to 1.94175 GHz and with 64 ug/ml frequency shifts from 1.95975 GHz to 1.94875 GHz with -120 dBc/Hz phase noise

A new nanocrystalline diamond-based biosensor for the detection of cardiovascular risk markers

In this paper, a new method to probe associative interactions of C-reactive protein (CRP) antigen with CRP antibody immobilized on a gold-interdigitated diamond electrodes was investigated. The CRP antigen detection was performed by capacitive/dielectric-constant measurements. Our results showed that the dynamic detection range using optimized conditions for a given antibody concentration (100 μg/ml) was found to be in the range 25-800 ng/ml of CRP-antigen. Biosensor developed in this study can be potentially used for detection of elevated CRP levels in suspected subjects for early diagnosis

Effects of Nickel Addition on the Microstructure of Laser-Welded UNS S32750 Duplex Stainless Steel

Welding duplex stainless steels with Nd:YAG pulsed laser welding results in an unbalanced microstructure. The present article reports the effects of nickel addition on the microstructure of UNS S32750 duplex stainless steel welded with an Nd:YAG pulsed laser. Two conditions were used: autogenous welding and welding with the addition of nickel. The addition of nickel resulted in equal proportions of austenite and ferrite in the weld bead, affecting the microstructure