13 research outputs found
Recommended from our members
Competitive Market Analysis of Transplant Centers and Discrepancy of Wait-Listing of Recipients for Kidney Transplantation
Background: There are over 250 kidney transplant programs in the USA. Objective: To determine if highly competitive regions, defined as regions with a higher number of transplant centers, will approve and wait-list more end-stage renal disease (ESRD) candidates for transplant despite consistent incidence and prevalence of ESRD nationwide. Methods: ESRD Network and OPTN data completed in 2011 were obtained from all transplant centers including listing data, market saturation, market share, organs transplanted, and ESRD prevalence. Herfindahl-Hirschman Index (HHI) was used to measure the size of firms in relation to the industry to determine the amount of competition. Results: States were separated into 3 groups (HHI1800 considered highly concentrated). The percentage of ESRD patients listed in competitive, moderate, and highly concentrated regions were 19.73%, 17.02%, and 13.75%, respectively. The ESRD listing difference between competitive versus highly concentrated was significant (p<0.05). Conclusion: When there is strong competition without a dominant center as defined by the HHI, the entire state tends to list more patients for transplant to drive up their own center’s market share. Our analysis of the available national data suggests a discrepancy in access for ESRD patient to transplantation due to transplant center competition
Efficient Polymerization Inhibition Systems for Acrylic Acid Distillation: New Liquid-Phase Inhibitors
Chromatographic determination of residual monomers in starch-g-polyacrylonitrile and starch-g-polyacrylate
Determination of nonionic and partially hydrolyzed polyacrylamide molecular weight distributions using hydrodynamic chromatography
Adsorptive Stripping-Voltammetrie von Oxytetracyclin an der h�ngenden Quecksilbertropfen-Elektrode in saurem Medium
Efficient Polymerization Inhibition Systems for Acrylic Acid Distillation: Vapor-Phase Inhibitors
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber’s law—the ¾-power law scaling of metabolism with bodyweight—and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.Kentaro Hirose, Alexander Y. Payumo, Stephen Cutie, Alison Hoang, Hao Zhang, Romain Guyot, Dominic Lunn, Rachel B. Bigley, Hongyao Yu, Jiajia Wang, Megan Smith, Ellen Gillett, Sandra E. Muroy, Tobias Schmid, Emily Wilson, Kenneth A. Field, DeeAnn M. Reeder, Malcom Maden, Michael M. Yartsev, Michael J. Wolfgang, Frank Grützner, Thomas S. Scanlan, Luke I. Szweda, Rochelle Buffenstein, Guang Hu, Frederic Flamant, Jeffrey E. Olgin, Guo N. Huan