FABRICATION AND CHARACTERIZATION OF FAST DISSOLVING FILMS OF ECLIPTA PROSTRATE LEAVES EXTRACT TO TREAT MOUTH ULCERS

Objective: This research focused on the design of fast dissolving herbal film of Eclipta Prostrate leaves extract for mouth ulcers. Methods: The extract of Eclipta Prostrata leaves was formulated as films by solvent casting method using various polymers viz., HPMC E5, HPMC E15, sodium alginate and PVA. The films were designed by using propylene glycol as a plasticizer, SSG as super disintegrate and honey as a sweetener. Furthermore, the films were evaluated for thickness, folding endurance, weight variation, % elongation, surface pH, % moisture uptake, % moisture loss, disintegration and in vitro drug release study. Results: The revealed that all the films were good in appearance and had a smooth texture. Out of all ten formulations, F3 and F5 disintegrated rapidly with a disintegration time of 27 and 32 seconds. The drug release studies revealed that all the formulations had a good release profile, but the F3 formulation showed rapid release i.e. 83.57% in 4 min. The stability studies revealed that the formulations F3 and F5 were found good with non-tackiness, easily separable and disintegrated at 29 and 33 sec respectively with no appearance and drug release. Conclusion: The research revealed that Eclipta prostrate leaves extract can be formulated into oral films for the treatment of mouth ulcers with improved bioavailability and expected patient compliance

Formulation, Design, Optimization and Evaluation of Cimetidine Floating Tablets by Using 32 Factorial Design

The present study was aimed to formulate and evaluate floating tablets of Cimetidine which is a histamine H2 receptor antagonist in increasing usage in the medical management of peptic ulcer. In this study, excipients like HPMC K4M ,HPMC K100M were used as polymers and sodium bi- carbonate were incorporated in 9 different  concentrations (F1-F9) along  with other excipients.to formulate floating tablets. Then all the nine formulations were evaluated for uniformity of weight, hardness, thickness, friability test, floating lag time, drug content, dissolution studies and stability studies.The 32 Factorial design experiments helps the investigator in resource management and economy. The dissolution profile of F2 was observed to be better than other formulations. Trial-F2 formulation showed a good dissolution profile for a controlled period of time which was noticed to be as 98 % at the end of 12th hour. Thus, it can be concluded that the floating drug delivery system of cimetidne using the appropriate polymers in right amount may enhance the activity of the drug by prolonging the gastric residence time or reducing the floating lag time