32 research outputs found
Long-term, Real-life, Observational Study in Treating Outpatient Ulcerative Colitis with Golimumab
Background and Aims: Several studies have found Golimumab (GOL) effective and safe in the short-term treatment of ulcerative colitis (UC), but few long-term data are currently available from real world. Our aim was to assess the long-term real-life efficacy and safety of GOL in managing UC outpatients in Italy.
Methods: A retrospective multicenter study assessing consecutive UC outpatients treated with GOL for at least 3-month of follow-up was made. Primary endpoints were the induction and maintenance of remission in UC, defined as Mayo score ≤2. Several secondary endpoints, including clinical response, colectomy rate, steroid free remission and mucosal healing, were also assessed during the follow-up.
Results: One hundred and seventy-eight patients were enrolled and followed up for a median (IQR) time of 9 (3-18) months (mean time follow-up: 33.1±13 months). Clinical remission was achieved in 57 (32.1%) patients: these patients continued with GOL, but only 6 patients (3.4%) were still under clinical remission with GOL at the 42nd month of follow-up. Clinical response occurred in 64 (36.4%) patients; colectomy was performed in 8 (7.8%) patients, all of them having primary failure. Steroid-free remission occurred in 23 (12.9%) patients, and mucosal healing was achieved in 29/89 (32.6%) patients. Adverse events occurred in 14 (7.9%) patients.
Conclusions: Golimumab does not seem able to maintain long-term remission in UC in real life. The safety profile was good
Disegni giovanili di Giovanni Guerra
Sessanta amici, colleghi e collaboratori di Gianni Carlo Sciolla, noto storico dell’arte e ordinario di Storia dell’arte moderna nell’Università di Torino, hanno contribuito con saggi e interventi originali alla realizzazione di questo volume, edito
in occasione del sessantesimo compleanno dello studioso.
- See more at: http://www.skira.net/l-arte-nella-storia.html#sthash.X78WVfEz.dpu
Le meraviglie di Roma antica e moderna: vedute, ricostruzioni, progetti nelle raccolte della Biblioteca di Archeologia e Storia dell'Arte; catalogo della mostra
Saggio su Rodolfo Lanciani archeologo e collezionista di disegni. Cura scientifica degli 80 disegni su Roma più significativi esposti nella mostra (Pirro Ligorio, G. B. Piranesi, A. Specchi, G. B. Nolli)
Disegni giovanili di Giovanni Guerra
Sessanta amici, colleghi e collaboratori di Gianni Carlo Sciolla, noto storico dell’arte e ordinario di Storia dell’arte moderna nell’Università di Torino, hanno contribuito con saggi e interventi originali alla realizzazione di questo volume, edito
in occasione del sessantesimo compleanno dello studioso.
- See more at: http://www.skira.net/l-arte-nella-storia.html#sthash.X78WVfEz.dpu