Human capital as a base for regional development : a case study

Purpose: The main aim of this article is to consider the main trends observed in the labor market in the regional agricultural sector. Design/Methodology/Approach: The study uses the statistical method, the method of analogy and comparison, as well as the positive and normative approach. Findings: The study indicated that in the agricultural sector there are several problems associated with the formation of human resources. This is evidenced by the presence of negative trends that have been observed over the past 20 years. The main problems are the low educational level of workers, aging professional staff, and a reduction in the number of employees in all positions. Practical implications: The socio-economic problems considered in the article indicate the urgent need to develop a mechanism of state support for agricultural workers. Originality/Value: The authors define the concept of human capital and reveal the essence of the factors influencing its formation, revealing them from the perspective of the socio-economic development of the region.peer-reviewe

Evaluation of children's day mode organization middle group of preschool educational organizations

The article discusses the results of the assessment of the daily regimen in children of middle preschool age in the preschool educational organization and beyond. The correct daily routine is important in the life of a preschool child, since it is during this period that the child’s body is especially sensitive to the effects of various external factors.В статье рассмотрены результаты проведённой оценки режима дня у детей среднего дошкольного возраста в дошкольной образовательной организации и за её пределами. Правильный режим дня имеет важное значение в жизни ребёнка дошкольного возраста, так как именно в этот период детский организм особенно чувствителен к воздействию различных внешних факторов

Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program.

The mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess two mechanistically similar systems to prevent the generation of mitochondrial reactive oxygen species (mROS): hexokinases I and II and creatine kinase bound to mitochondrial membranes. Both systems operate in a manner such that one of the kinase substrates (mitochondrial ATP) is electrophoretically transported by the ATP/ADP antiporter to the catalytic site of bound hexokinase or bound creatine kinase without ATP dilution in the cytosol. One of the kinase reaction products, ADP, is transported back to the mitochondrial matrix via the antiporter, again through an electrophoretic process without cytosol dilution. The system in question continuously supports H <sup>+</sup> -ATP synthase with ADP until glucose or creatine is available. Under these conditions, the membrane potential, ∆ψ, is maintained at a lower than maximal level (i.e., mild depolarization of mitochondria). This ∆ψ decrease is sufficient to completely inhibit mROS generation. In 2.5-y-old mice, mild depolarization disappears in the skeletal muscles, diaphragm, heart, spleen, and brain and partially in the lung and kidney. This age-dependent decrease in the levels of bound kinases is not observed in NMRs and bats for many years. As a result, ROS-mediated protein damage, which is substantial during the aging of short-lived mice, is stabilized at low levels during the aging of long-lived NMRs and bats. It is suggested that this mitochondrial mild depolarization is a crucial component of the mitochondrial anti-aging system

ASTRA: ASTrometry and phase-Referencing Astronomy on the Keck interferometer

ASTRA (ASTrometric and phase-Referencing Astronomy) is an upgrade to the existing Keck Interferometer which aims at providing new self-phase referencing (high spectral resolution observation of YSOs), dual-field phase referencing (sensitive AGN observations), and astrometric (known exoplanetary systems characterization and galactic center general relativity in strong field regime) capabilities. With the first high spectral resolution mode now offered to the community, this contribution focuses on the progress of the dual field and astrometric modes.Comment: 10 pages, 6 figures, 2 tables, SPIE 201

Acute cerebellar ataxia in a young woman: Wernicke’s encephalopathy?

Wernicke’s encephalopathy (WE) is a rare but severe neurological syndrome caused by thiamine deficiency. According to the data of autopsy studies, the prevalence of WE in the general population varies from 0.4 to 2.8 per 100,000 population; the disease occurs many times more frequently in alcohol abusers than in people who lead a healthy lifestyle. These studies also showed that most cases of WE were diagnosed postmortem; less than 20% of patients with the disease were diagnosed in life. A healthy adult requires 1–2 mg of thiamine daily, depending on the carbohydrate intake. Body’s reserves of thiamine are only 30–50 mg so any malnutrition condition lasting more than 3–4 weeks can cause complete depletion of the vitamin’s stores. Classically, WE is characterized by the sudden onset of a typical triad of symptoms: an altered mental state, ophthalmoplegia, and ataxia. However, this clinical picture can be seen in only one-third of patients. The onset of the disease may sometimes look completely different: heart failure with hypotension and tachycardia; gastrointestinal symptoms (abdominal pain and nausea); hypothermia due to the involvement of the posterior hypothalamus; deafness affecting the thalamus; epileptic seizures in case of enhanced activity of the glutamatergic system.The paper describes a clinical case of acute cerebellar ataxia that is apparently caused by Wernicke’s encephalopathy in a young woman

Recent progress at the Keck Interferometer

The Keck Interferometer (KI) combines the two 10m diameter Keck telescopes providing milliarcsecond angular resolution. KI has unique observing capabilities such as sensitive K-band V^2, L-band V^2 and N-band nulling modes. The instrument improvements and status of the Keck Interferometer since the 2010 SPIE meeting are summarized. We discuss the current capabilities of the KI, operational improvements, and the science from the KI during the past two years. We will conclude with a brief note on the closure of the KI facility. Details of dual field phase referencing developments and nulling science results are presented elsewhere at this conference

Keck Interferometer Nuller Data Reduction and On-Sky Performance

We describe the Keck Interferometer nuller theory of operation, data reduction, and on-sky performance, particularly as it applies to the nuller exozodiacal dust key science program that was carried out between 2008 February and 2009 January. We review the nuller implementation, including the detailed phasor processing involved in implementing the null-peak mode used for science data and the sequencing used for science observing. We then describe the Level 1 reduction to convert the instrument telemetry streams to raw null leakages, and the Level 2 reduction to provide calibrated null leakages. The Level 1 reduction uses conservative, primarily linear processing, implemented consistently for science and calibrator stars. The Level 2 processing is more flexible, and uses diameters for the calibrator stars measured contemporaneously with the interferometer’s K-band cophasing system in order to provide the requisite accuracy. Using the key science data set of 462 total scans, we assess the instrument performance for sensitivity and systematic error. At 2.0 Jy we achieve a photometrically-limited null leakage uncertainty of 0.25% rms per 10 minutes of integration time in our broadband channel. From analysis of the Level 2 reductions, we estimate a systematic noise floor for bright stars of ~0.2% rms null leakage uncertainty per observing cluster in the broadband channel. A similar analysis is performed for the narrowband channels. We also provide additional information needed for science reduction, including details on the instrument beam pattern and the basic astrophysical response of the system, and references to the data reduction and modeling tools

Milliarcsecond N-Band Observations of the Nova RS Ophiuchi: First Science with the Keck Interferometer Nuller

We report observations of the nova RS Ophiuchi (RS Oph) using the Keck Interferometer Nuller (KIN), approximately 3.8 days following the most recent outburst that occurred on 2006 February 12. These observations represent the first scientific results from the KIN, which operates in N-band from 8 to 12.5 microns in a nulling mode. By fitting the unique KIN data, we have obtained an angular size of the mid-infrared continuum of 6.2, 4.0, or 5.4 mas for a disk profile, gaussian profile (FWHM), and shell profile respectively. The data show evidence of enhanced neutral atomic hydrogen emission and atomic metals including silicon located in the inner spatial regime near the white dwarf (WD) relative to the outer regime. There are also nebular emission lines and evidence of hot silicate dust in the outer spatial region, centered at ! 17 AU from the WD, that are not found in the inner regime. Our evidence suggests that these features have been excited by the nova flash in the outer spatial regime before the blast wave reached these regions. These identifications support a model in which the dust appears to be present between outbursts and is not created during the outburst event. We further discuss the present results in terms of a unifying model of the system that includes an increase in density in the plane of the orbit of the two stars created by a spiral shock wave caused by the motion of the stars through the cool wind of the red giant star. These data show the power and potential of the nulling technique which has been developed for the detection of Earth-like planets around nearby stars for the Terrestrial Planet Finder Mission and Darwin missions.Comment: 41 pages, 10 figure

Anticorrosive effects and antimicrobial properties of alkyldimethyl(hydroxyalkyl)ammonium bromides

Quaternary ammonium compounds containing the hydroxyalkyl moiety in the head group have been synthesized. These compounds exhibit a micelle-forming ability, high anticorrosive activity, and antimicrobial action. The compounds of the formula R(CH3)2N+(CH2CH 2CH2OH)Br- with R = C14H 29-C18H37 are characterized by a protective effect higher than 90-99% at 10 mg/l with respect to hydrogen sulfide corrosion, inhibiting properties against carbon dioxide corrosion (84-98% at 10-25 mg/l), and bactericidal action on sulfate-reducing bacteria (10-50 mg/l). © 2011 Pleiades Publishing, Ltd