Development and validation of RP – HPLC method for quantitation of luliconazole in bulk and formulation

A new simple, specific, precise & validated Analytical Method has been developed for the determination of Luliconazole in bulk and pharmaceutical formulation. The separation was achieved on a C18 ODS (250×4.6 mm,5µm) or using mobile phase consisting of methanol: water (85:15) at a flow rate of 1.0 ml/min. Detection was carried out at 296nm. The retention time of Luliconazole was found to be 4.2min. the calibration curve found linear between range of 20-60 µg/ml with a regression coefficient of 0. 9998. The percentage recovery of Luliconazole was found to be in the range of 90-110%. The method was validated in accordance with International Conference on Harmonization. LOD & LOQ for Luliconazole were found to be 0.24μg & 0.748μg/ml respectively. Present method is simple, precise and can be used in routine analysis of Luliconazole in bulk and pharmaceutical lotion

Pediatric Hodgkin Lymphoma: Making Progress

Hodgkin lymphoma (HL) is one of the more common cancers encountered among pediatric and adolescent patients; however, most HL occurs in adults, and children constitute only a small proportion of the total number of cases. Treatment outcomes for pediatric HL are excellent and current strategies focus on reduction of therapy-related toxicity while maintaining high survival. This has been achieved by identifying patient cohorts who are at a lower risk for relapse and can be successfully treated with reduced amounts of chemotherapeutic agents and radiation therapy. This identification has been assisted by better understanding of newer imaging modalities, in particular functional FDG–PET imaging. Patients who fail first-line therapy continue to have a chance of cure, and a variety of modalities are available for their treatment. New therapeutic agents, both traditional and biological, are under assessment