A new formulation of oral viscous budesonide in treating of paediatric eosinophilic oesophagitis: a pilot study

OBJECTIVES: Oral viscous budesonide is a recent therapeutic option for eosinophilic oesophagitis (EoE) compared with dietary restriction and inhaled steroids. This single-centre, open-label, not blinded study aims to evaluate the efficacy and safety of a new, preprepared oral viscous budesonide suspension (PVB) in children and adolescents with EoE. METHODS: We treated 36 children with PVB (29 boys; median age 12 years) with EoE diagnosed according to European Society for Paediatric Gastroenterology Hepatology and Nutrition guidelines. Patients <150 and >150 cm height received 2 and 4 mg PVB daily, respectively, for 12 weeks. Upper gastrointestinal endoscopy was performed at baseline, after 12 weeks of therapy and 24 weeks after the end of therapy. Baseline and post-treatment scores were calculated for symptoms, endoscopy, and histology. Serum cortisol was performed at baseline, 12, and 36 weeks. RESULTS: At the end of PVB trial, endoscopy showed macroscopic remission in 32 patients (88.9%), whereas at histology median pre- and post-treatment peak eosinophil count/high power field (HPF) markedly decreased from 42.2 (range: 15-100) to 2.9 (range: 0-30); moreover, mean symptom and histology scores impressively improved compared with baseline (P < 0.01). At 24 weeks after the end of PVB therapy, endoscopy showed oesophageal relapse in 21 patients (58.3%), whereas 15 (41.7%) were still in remission. Seven children (19.4%) with positive multichannel intraluminal impedance-pH were treated also with proton pump inhibitors. No significant difference between pre-/post-treatment morning cortisol levels occurred. CONCLUSIONS: The new PVB suspension presented in the present study is effective and safe for treating children with proven EoE. Larger placebo-controlled clinical trials would provide more information about dosing, efficacy, and long-term safety of this formulation, specifically designed for the oesophagus

GPCALMA: a Grid Approach to Mammographic Screening

The next generation of High Energy Physics experiments requires a GRID approach to a distributed computing system and the associated data management: the key concept is the "Virtual Organisation" (VO), a group of geographycally distributed users with a common goal and the will to share their resources. A similar approach is being applied to a group of Hospitals which joined the GPCALMA project (Grid Platform for Computer Assisted Library for MAmmography), which will allow common screening programs for early diagnosis of breast and, in the future, lung cancer. HEP techniques come into play in writing the application code, which makes use of neural networks for the image analysis and shows performances similar to radiologists in the diagnosis. GRID technologies will allow remote image analysis and interactive online diagnosis, with a relevant reduction of the delays presently associated to screening programs.Comment: 4 pages, 3 figures; to appear in the Proceedings of Frontier Detectors For Frontier Physics, 9th Pisa Meeting on Advanced Detectors, 25-31 May 2003, La Biodola, Isola d'Elba, Ital

The TNG Near Infrared Camera Spectrometer

NICS (acronym for Near Infrared Camera Spectrometer) is the near-infrared cooled camera-spectrometer that has been developed by the Arcetri Infrared Group at the Arcetri Astrophysical Observatory, in collaboration with the CAISMI-CNR for the TNG (the Italian National Telescope Galileo at La Palma, Canary Islands, Spain). As NICS is in its scientific commissioning phase, we report its observing capabilities in the near-infrared bands at the TNG, along with the measured performance and the limiting magnitudes. We also describe some technical details of the project, such as cryogenics, mechanics, and the system which executes data acquisition and control, along with the related software.Comment: 7 pages, 5 figures, compiled with A&A macros. A&A in pres

Kripke Semantics for Intuitionistic Lukasiewicz Logic

This paper proposes a generalization of the Kripke semantics of intuitionistic logic IL appropriate for intuitionistic Łukasiewicz logicIŁL —a logic in the intersection between IL and (classical) Łukasiewicz logic. This generalised Kripke semantics is based on the poset sum construction, used in Bova and Montagna (Theoret Comput Sci 410(12):1143–1158, 2009). to show the decidability (and PSPACE completeness) of the quasiequational theory of commutative, integral and bounded GBL algebras. The main idea is that $w \Vdash \psi$—which for ILis a relation between worlds w and formulas $\psi$, and can be seen as a function taking values in the booleans $(w \Vdash \psi ) \in {{\mathbb {B}}}$—becomes a function taking values in the unit interval $(w \Vdash \psi ) \in [0,1]$. An appropriate monotonicity restriction (which we call sloping functions) needs to be put on such functions in order to ensure soundness and completeness of the semantics

A Survey of Merger Remnants II: The Emerging Kinematic and Photometric Correlations

This paper is the second in a series exploring the properties of 51 {\it optically} selected, single-nuclei merger remnants. Spectroscopic data have been obtained for a sub-sample of 38 mergers and combined with previously obtained infrared photometry to test whether mergers exhibit the same correlations as elliptical galaxies among parameters such as stellar luminosity and distribution, central stellar velocity dispersion ($\sigma$$_{\circ}$), and metallicity. Paramount to the study is to test whether mergers lie on the Fundamental Plane. Measurements of $\sigma$$_{\circ}$ have been made using the Ca triplet absorption line at 8500 {\AA} for all 38 mergers in the sub-sample. Additional measurements of $\sigma$$_{\circ}$ were made for two of the mergers in the sub-sample using the CO absorption line at 2.29 \micron. The results indicate that mergers show a strong correlation among the parameters of the Fundamental Plane but fail to show a strong correlation between $\sigma$$_{\circ}$ and metallicity (Mg$_{2}$). In contrast to earlier studies, the $\sigma$$_{\circ}$ of the mergers are consistent with objects which lie somewhere between intermediate-mass and luminous giant elliptical galaxies. However, the discrepancies with earlier studies appears to correlate with whether the Ca triplet or CO absorption lines are used to derive $\sigma$$_{\circ}$, with the latter almost always producing smaller values. Finally, the photometric and kinematic data are used to demonstrate for the first time that the central phase-space density of mergers are equivalent to elliptical galaxies. This resolves a long-standing criticism of the merger hypothesis.Comment: Accepted Astronomical Journal (to appear in January 2006

The Nuclear Stellar Cluster in the Seyfert~1 Galaxy NGC 3227: High Angular Resolution NIR Imaging and Spectroscopy

NIR high angular resolution speckle imaging and imaging spectroscopy of the nuclear region (10'' ~ 840pc) of the Seyfert1 galaxy NGC3227 are presented. A nuclear stellar cluster is slightly resolved in the J and H band with increasing contribution to the NIR continuum from the K to the J band. The stellar absorption lines are extended compared to the neighboring continuum suggesting a cluster size of ~ 70pc FWHM. Analysis of those lines suggests that the stars are contributing about 65% (40%) of the total continuum emission in the H (K) band in a 3.6'' aperture. Population synthesis in conjunction with NIR spectral synthesis indicates an age of 25 to 50 Myr when red supergiants contribute most to the NIR light. This is supported by published optical data on the MgIb line and the CaII triplet. Although a higher age of ~ 0.5 Gyr where AGB stars dominate the NIR light can not be excluded, the observed parameters are at the limit of those expected for a cluster dominated by AGB stars. However, in either case the resolved stellar cluster contributes only about ~ 15 % of the total dynamical mass in the inner 300pc implying another much older stellar population. Pure constant star formation over the last 10 Gyr can be excluded. Therefore, at least two star formation/starburst events took place in the nucleus of NGC3227. Since such sequences in the nuclear star formation history are also observed in the nuclei of other galaxies a link between the activity of the star formation and the AGN itself seems likely.Comment: accepted for publication in the Astrophysical Journal, 46 pages, 15 figure