4,766 research outputs found
A low-loss photonic silica nanofiber for higher-order modes
Optical nanofibers confine light to subwavelength scales, and are of interest
for the design, integration, and interconnection of nanophotonic devices. Here
we demonstrate high transmission (> 97%) of the first family of excited modes
through a 350 nm radius fiber, by appropriate choice of the fiber and precise
control of the taper geometry. We can design the nanofibers so that these modes
propagate with most of their energy outside the waist region. We also present
an optical setup for selectively launching these modes with less than 1%
fundamental mode contamination. Our experimental results are in good agreement
with simulations of the propagation. Multimode optical nanofibers expand the
photonic toolbox, and may aid in the realization of a fully integrated
nanoscale device for communication science, laser science or other sensing
applications.Comment: 12 pages, 5 figures, movies available onlin
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Effect of natural genetic variation on enhancer selection and function.
The mechanisms by which genetic variation affects transcription regulation and phenotypes at the nucleotide level are incompletely understood. Here we use natural genetic variation as an in vivo mutagenesis screen to assess the genome-wide effects of sequence variation on lineage-determining and signal-specific transcription factor binding, epigenomics and transcriptional outcomes in primary macrophages from different mouse strains. We find substantial genetic evidence to support the concept that lineage-determining transcription factors define epigenetic and transcriptomic states by selecting enhancer-like regions in the genome in a collaborative fashion and facilitating binding of signal-dependent factors. This hierarchical model of transcription factor function suggests that limited sets of genomic data for lineage-determining transcription factors and informative histone modifications can be used for the prioritization of disease-associated regulatory variants
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