Direct Determination of DNA Twist-Stretch Coupling

The symmetries of the DNA double helix require a new term in its linear response to stress: the coupling between twist and stretch. Recent experiments with torsionally-constrained single molecules give the first direct measurement of this important material parameter. We extract its value from a recent experiment of Strick et al. [Science 271 (1996) 1835] and find rough agreement with an independent experimental estimate recently given by Marko. We also present a very simple microscopic theory predicting a value comparable to the one observed.Comment: Plain TeX file; uses harvmac and epsf; .ps also available at http://dept.physics.upenn.edu/~nelson/twiststretch.ps or http://dept.physics.upenn.edu/~nelson/twiststretch.ps.g

Endocrine disruption in fish: An assessment of recent research and results

This report provides an assessment of recent investigations into endocrine disruption in fresh and saltwater species of fish. Most work to date has concen-trated on reproductive endocrine disruption. Laboratory studies have shown a variety of synthetic and natural chemicals including certain industrial intermediates, PAHs, PCBs, pesticides, dioxins, trace elements and plant sterols can interfere with the endocrine system in fish. The potency of most of these chemicals, however, is typically hundreds to thousands of times less than that of endog-enous hormones. Evidence of environmental endocrine disruption ranges from the presence of female egg proteins in males and reduced levels of endogenous hormones in both males and females, to gonadal histopathologies and intersex (presence of ovotestes) fish. Overt endocrine disruption in fish does not appear to be a ubiquitous environmental phenomenon, but rather more likely to occur near sewage treatment plants, pulp and paper mills, and in areas of high organic chemical contamination. However, more wide-spread endocrine disruption can occur in rivers with smaller flows and correspondingly large or numerous wastewater inputs. Some of the most severe examples of endocrine disruption in fish have been found adjacent to sewage treatment plants. Effects are thought to be caused prima-rily by natural and synthetic estrogens and to a lesser extent by the degradation products of alkylphenol poly-ethoxylate surfactants. Effects found in fish near pulp and paper mills include reduced levels of estrogens and androgens as well as masculinization of females, and has been linked to the presence of β-sitosterol, a plant sterol. Effects seen in areas of heavy industrial activity typically include depressed levels of estrogens and androgens as well as reduced gonadal growth, and may be linked to the presence of PAHs, PCBs, and possibly dioxins. At this time, however, there is no clear indication that large populations of fish are being seriously impacted as a result of endocrine disruption, although additional work is needed to address this possibility. (PDF contains 63 pages

Models for the Observable System Parameters of Ultraluminous X-ray Sources

We investigate the evolution of the properties of model populations of ultraluminous X-ray sources (ULXs) consisting of a black-hole accretor in a binary with a donor star. We have computed models corresponding to three different populations of black-hole binaries; two invoke stellar-mass (~10 Msun) black hole accretors, and the third utilizes intermediate-mass (~1000 Msun) black holes (IMBHs). For each of the three populations, we computed 30,000 binary evolution sequences using a full Henyey stellar evolution code. The optical flux from the model ULXs includes contributions from the accretion disk, due to x-ray irradiation as well as intrinsic viscous heating, and that due to the donor star. We present "probability images" for the ULX systems in planes of color-magnitude, orbital period vs. X-ray luminosity, and luminosity vs. evolution time. Estimates of the numbers of ULXs in a typical galaxy as functions of time and of X-ray luminosity are also presented. Our model CMDs are compared with six ULX counterparts that have been discussed in the literature. Overall, the observed systems seem more closely related to model systems with very high-mass donors (> ~25 Msun) in binaries with IMBH accretors. However, significant difficulties remain with both the IMBH and stellar-mass black hole models.Comment: 15 pages, 8 figures, submitted to ApJ on Oct 05, 200

Men Are from Mars, Women Are from Venus: Evaluation and Modelling of Verbal Associations

We present a quantitative analysis of human word association pairs and study the types of relations presented in the associations. We put our main focus on the correlation between response types and respondent characteristics such as occupation and gender by contrasting syntagmatic and paradigmatic associations. Finally, we propose a personalised distributed word association model and show the importance of incorporating demographic factors into the models commonly used in natural language processing.Comment: AIST 2017 camera-read

Models of Ultraluminous X-Ray Sources with Intermediate-Mass Black Holes

We have computed models for ultraluminous X-ray sources ("ULXs") consisting of a black-hole accretor of intermediate mass ("IMBH"; e.g., ~1000 Msun) and a captured donor star. For each of four different sets of initial donor masses and orbital separations, we computed 30,000 binary evolution models using a full Henyey stellar evolution code. To our knowledge this is the first time that a population of X-ray binaries this large has been carried out with other than approximation methods, and it serves to demonstrate the feasibility of this approach to large-scale population studies of mass-transfer binaries. In the present study, we find that in order to have a plausible efficiency for producing active ULX systems with IMBHs having luminosities > 10^{40} ergs/sec, there are two basic requirements for the capture of companion/donor stars. First, the donor stars should be massive, i.e., > 8 Msun. Second, the initial orbital separations, after circularization, should be close, i.e., < 6-30 times the radius of the donor star when on the main sequence. Even under these optimistic conditions, we show that the production rate of IMBH-ULX systems may fall short of the observed values by factors of 10-100.Comment: 5 pages, 2 figures, submitted to Ap

Photometric, Spectroscopic and Orbital Period Study of Three Early Type Semi-detached Systems: XZ Aql, UX Her and AT Peg

In this paper we present a combined photometric, spectroscopic and orbital period study of three early-type eclipsing binary systems: XZ Aql, UX Her, and AT Peg. As a result, we have derived the absolute parameters of their components and, on that basis, we discuss their evolutionary states. Furthermore, we compare their parameters with those of other binary systems and with the theoretical models. An analysis of all available up-to-date times of minima indicated that all three systems studied here show cyclic orbital changes, their origin is discussed in detail. Finally, we performed a frequency analysis for possible pulsational behavior and as a result we suggest that XZ Aql hosts a {\delta} Scuti component.Comment: 40 pages, 16 figure

Translational Correlations in the Vortex Array at the Surface of a Type-II Superconductor

We discuss the statistical mechanics of magnetic flux lines in a finite-thickness slab of type-II superconductor. The long wavelength properties of a flux-line liquid in a slab geometry are described by a hydrodynamic free energy that incorporates the boundary conditions on the flux lines at the sample's surface as a surface contribution to the free energy. Bulk and surface weak disorder are modeled via Gaussian impurity potentials. This free energy is used to evaluate the two-dimensional structure factor of the flux-line tips at the sample surface. We find that surface interaction always dominates in determining the decay of translational correlations in the asymptotic long-wavelength limit. On the other hand, such large length scales have not been probed by the decoration experiments. Our results indicate that the translational correlations extracted from the analysis of the Bitter patterns are indeed representative of behavior of flux lines in the bulk.Comment: 23 pages, 1 figure (not included), harvmac.tex macro needed (e-mail requests to [email protected] SU-CM-92-01