Assessment of Occupational Diseases among Artisans and Factory Workers in Ifo, Nigeria

The ever increasing incidences of occupational diseases among workers have continually drawn the attention of researchers towards ameliorating the situation. Investigation was launched to assess occupational diseases among artisans and factory workers in Ifo, Nigeria. Structured questionnaires with oral interview were employed to complement the health records of the respondents at the Government accredited health center. Of the one hundred and fifty six (156) respondents, ninety six (62%) are males and sixty one (38%) female, sixty one point fifty four percent (61.54%) are youths of age 20 to 39 years, fifty one (32.69%) are illiterates and one hundred and eight (69.21%) earn N100, 000 ($615) and below as monthly wages. The diseases prevalent in these workers were evaluated to include but not limited to disorders of muscles, bones, joints, skin and the respiratory organs indicating that most of the jobs are such that causes damages to these special parts of the body and could lead to deformities/incapacitation in old age. Common amongst these diseases are Pre-patellar bursitis and Eczema (1.92% each), Tuberculosis, Asthma and Sunburn (5.77% each). Toxic/inflammatory syndrome, hearing impairment, allergies and computer vision syndrome (7.69% each). Two (1.28% in each case) have been diagnosed of Lead poisoning, Lung cancer, Carpal tunnel syndrome, Pulmonary fibrosis, Meniscus lesion and Olecranon bursitis. Upper airway disorders (4.49%), Irritations (3.21%), Post-traumatic stress syndrome (11.54%), skin allergies (13.46%). Chronic bronchitis; Pneumonia; Pneumoconiosis; Hepatitis and Anthrax-like infection (0.64 % each). The causes of these diseases/disorders include dusts from quarry, textile, cotton, metal, paper, mineral, wood, cereals, cement, and chemical fumes industries, extreme posture of wrist, repetitive movements, inhalations from petrol fuel, prolonged pressure of the elbow region, prolonged kneeling/ squatting position, forceful exertions and microorganisms. Adequate occupational health and safety awareness through training and campaign should be provided. The use of personal protective equipment among workers should also be encouraged

DETERMINANTS OF UTILIZATION AND PARTICIPATION IN THE COLLECTION AND SALES OF FOREST PLANT LEAVES IN OGUN STATE, NIGERIA

Determinants of participation in the collection and sales of forest plant leaves in Ogun state were investigated. Multistage sampling procedure was employed to select three hundred (300) respondents for the study. A structure questionnaire was used to elicit information from the respondents. Data obtained were analyzed using descriptive statistics, logit regression and budgetary analysis. The logit regression analysis results showed that the likelihood of utilization of the forest plant leaves is significantly determined by nature of the respondents occupation (farming and NTFPs) and their household size while the likelihood of participation in the collection and sales of forest plant leaves is significantly determined by nearness to the forest plant leaves, income realized from the leaves and gender. Sales of leaves were profitable with an average net profit of N14,179.17/month/respondent. Enlighten programs on forest plant leaves activities as means of livelihood and alleviation of poverty should be embarked upon for rural folks. &nbsp

Influence of Magnetic Field and Thermal Radiation on Steady Free Convective Flow in a Porous Medium

This paper investigated the influence of magnetic field and thermal radiation on steady free convective flow embedded in a porous medium with Soret effects. The governing equations are systems of nonlinear partial differential equations. Similarity variables were introduced on the set of governing equations and it was transformed into set of coupled nonlinear ordinary differential equations. The transformed coupled nonlinear ordinary differential equations are solved using the Spectral Homotopy Analysis Method (SHAM). Influence of pertinent flow parameters is displayed in figures and table. Comparisons were done with existing problems/models in literature and our results were in good agreement. The results revealed that as the magnetic parameter increased the velocity profile was found to decrease as a result of the magnetic field applied in the direction of the flow but negligible or has no effect on the velocity distribution. The results shows that increase in the suction/injection velocity and Magnetic field parameter enrich the temperature and concentration.KEYWORDS: Buoyancy; Free Convective Flow; Magnetic Field; Porous Medium; Soret; Suction/Injection

PROCESS TECHNOLOGY, CHEMICAL COMPOSITION AND QUALITY OF "AADUN" A MAIZE- BASED NIGERIAN SNACK

Process technology, chemical composition and sensory quality of "aadun"- a maize based Nigeriansnack were investigated. Process technology was established through oral interview and visitation toprocessors at Abeokuta and Ibadan, while "aadun" samples were evaluated for their chemical compositionand sensory quality using laboratory samples as control. Although ingredient composition variedwidely among processors, roasted maize flour and palm oil constitute about 71 and 27 % of the ingredientsrespectively. Pepper, salt and other spices added up to only 1- 2%. The major unit operationsidentified in "aadun" processing were: cleaning, roasting, milling, sieving, mixing, molding and packaging."Aadun" was found to be very rich in calorie (495.34- 618.84kcal/ 100g), low in protein (4.95-6.08%) and a good source of phosphorus (538.45- 600mg/100g) and magnesium (245.05-255.12mg/100g). Sensory quality of "aadun" is processor dependent as samples differ significantly(p> 0.05) in their colour, aroma, texture and overall acceptability but not in taste. "Aadun" samplesgenerally had low microbial loads with total plate count ranging between 1.2 x103 and 3.3x103cfu/g

Biomembrane Modelling in Planar Chromatographic Determination of Lipophilicity Using Olive and Castor Oils

BackgroundLipophilicity is a crucial physicochemical parameter that predicts in vivo pharmacokinetics and should be reliably estimated in early stage drug discovery to reduce incidence of attrition. Previous methodologies for its measurement often lead to technically incorrect decisions due to simplistic architecture and poor biomimetic attributes. Significantly, a certain seed oil, used for biomembrane modelling on planar chromatographic platform, was reported to be sufficiently biomimetic and fit for purpose.ObjectivesTo evaluate olive oil (OL) and olive-castor oil (OL-C) equi-mixture as lipids for biomembrane simulation on planar chromatographic platform.Material and MethodRetention behavior of nabumetone, a model compound was used to optimize these potential lipid membranes using a thin film engineered from 5% Liquid paraffin (LP) as benchmark, while halofantrine, nabumetone , α-naphthol and β-naphthol representing varying molecular polarities, were used for validation studies. The validation involved 2-way analysis of variance (ANOVA) associated with variability in Basic lipophilicity parameter (Rmw), and Specific hydrophobic surface area (SHSA) for the optimized surfaces, relative to LP and octadecylsilane (ODS) Further validation entailed correlation of the lipophilicity descriptor i.e. isocratic chromatographic hydrophobicity index (ICHI) on OL, OL-C, ODS and LP with experimental Log P(octanol/water).ResultsOptimized film thicknesses were produced by 5% OL and 1.25% OL-C (p > 0.05). The 2-way ANOVA revealed great variability in performance characteristics of the surfaces (p < 0.0001), and the new surfaces also gave poorer correlation with Log P values (R2= 0.502 and 0.449 respectively).ConclusionThe 1.25 % OL-C demonstrated a higher biomimetic attribute and warrants further validation studies to ascertain biorelevance, of lipophilicity measurement on this platform, in predicting oral drug absorption. Keywords: Lipophilicity, Reversed-phase Thin Layer Chromatography, Retention behaviour, Olive oil, Castor oi

Comparative in-vitro studies on the efficacy of ivermectin against gastrointestinal sheep nematode

Purpose: This study was designed to evaluate the relative efficacy of various brands of ivermectin injection available for use in clinical veterinary practice in Nigeria. Method: Ivermectin injections were evaluated by a larval development assay (LDVA), using the larvae of Strongyles (predominantly Haemonchus contortus) of sheep. The effect of standard solutions of the drug from the various brands on the transformation of L1 to L3 and survival of L3 larvae was used to assess bioactivity. The 50% lethal concentration (LC50) was determined from regression line obtained by probit transformation of the biological data. The LC50 values for each of the brands were compared with that of the innovator brand (Ivomec Superâ) for any significant difference. Results: The LC50 values obtained for the five brands varied widely. It ranges from 1.1±0.17 ng/ml for the innovator brand to 2.3±0.3, 3.0±0.3, 8.0±0.2 and 17.0±0.3 ng/ml for the other four brands. The biological assays performed on each of the five brands were of comparable precision. LC50 for Ivomec superâ was significantly different from those of the other four brands (Student's t test, p < 0.01). Conclusion: The bioactivities of brands of ivermectin injections available in Nigeria are significantly different. This is a probable reason for the varied treatment response to various brands of ivermectin injection in veterinary practice in Nigeria. This justifies the need for drug regulatory bodies in Nigeria to ensure that ivermectin injections registered for use in Nigeria meets approved standards before the drugs are allowed to be imported into the country. Key words: Bioactivity, ivermectin, sheep nematode Trop J Pharm Res, December 2003; 2(2): 235-23

Improved Colorimetric Determination of Reserpine in Tablets Using 4-Caboxyl-2,6-dintrobenzene diazonium ion (CDNBD)

Purpose: To develop a simple, rapid and improved colorimetric method for the assay of reserpine in tablets Method: The method is based on the aromatic ring coupling of reserpine with 4-carboxyl-2,6-dinitrobenzene diazonium ion with the consequent formation of an azo adduct. Optimization of reaction conditions and validation were carried out and the method applied to assay of reserpine in tablets. Result: Reserpine coupled readily with CDNBD and optimization of experimental conditions showed the reaction to be completed in 10 min at room temperature. A 1:1 drug to reagent stoichiometric ratio was obtained for the azo adduct formed. The adduct exhibited a bathochromic shift with respect to the drug and pronounced hyperchromic shift with respect to the reagent. Sample analyses were done using a colorimeter at 470 nm. The assays were linear and reproducible over the concentration range of 2.25 -24 µg/mL. The new method was successfully applied in the assay of reserpine in tablets with a performance similar to the official (USP) spectrophotometric method (p > 0.05). This method represents a profound improvement on the previously reported colorimetric method for reserpine. Conclusion: The method developed is rapid and could find application in in-process quality control of reserpine. Keywords: Reserpine, colorimetry, 4-Caboxyl-2,6-dintrobenzene diazonium ion (CDNBD), diazo coupling > Tropical Journal of Pharmaceutical Research Vol. 6 (2) 2007: pp. 695-70

Comparative study of the macroinvertebrate community composition and water quality of Ona and Opa rivers, Southwestern Nigeria

Macroinvertebrate samples of Ona and Opa rivers were taken fortnightly between April and August, 2013 with the aid of a dip net of 500µm mesh size with the aim of evaluating the macroinvertebrate community composition and the water quality of the rivers. A total of 617 individuals macroinvertebrate belonging to 29 species were collected. Ona River was dominated by Chironomid larvae while Opa River was dominated by Trichoptera species. Margalef’ species richness and Shannon-wiener’s species diversity indices both revealed that Opa River is higher in terms of species richness and diversity. The physico-chemical parameters of the two water bodies showed a slightly marked variation, especially for Dissolved Oxygen, Conductivity and Total Dissolved Solids. Ona River was relatively lower in DO level but showed a higher TDS level than Opa River. The species composition and the water quality both indicated that Ona River is more stressed than Opa River due to greater impacts of anthropogenic activities which brought about the observed organically-induced pollution in the water body

IMPACT OF ENLIGHTENMENT AND MONITORING ON THE USE OF LONG LASTING INSECTICIDE NETS FOR MALARIA PREVENTION AMONG CHILDREN UNDER FIVE YEARS IN A RURAL COMMUNITY IN ABEOKUTA, NIGERIA

The female Anopheles mosquito is the vector for human malaria and bites man mostly from 5pm to 7am, with maximum intensity between 10pm and 4am. This provides the basis for the use of Long Lasting Insecticide Nets (LLIN). A study to assess the impact of enlightenment, advocacy and monitoring on LLIN use for children under five years was conducted in Olugbo. A total of two hundred (200) children under five years were recruited into the study. Ethical clearance was received from the Ogun State Ministry of Health. Pre-tested questionnaires were administered to the respondents and blood samples were collected for malaria test before and after provision(Pre and Post intervention) of LLIN. The blood samples were analyzed at the laboratory using the QBC Malaria Test and ParaLens system. The subjects were divided into two groups of study (group that received LLIN, enlightenment on the importance of LLIN and assisted with LLIN hanging) and Control (group that merely received the LLIN without enlightenment or assistance). The subjects in the study group were monitored between 1600hrs to 2000hrs thrice a week. The pre intervention study result shows that the prevalence of malaria infection was 70% and 56% amongst the study and Control group respectively. The post intervention blood samples screening reveals that the prevalence of infection in the study group was 13% with low parasite density. In the Control group, however, the prevalence of infection was 60% and 38.33% of those infected had high parasite density. There is a significant difference (P&lt;0.05) in malaria parasitaemia between both groups post intervention. This study shows that distribution of LLINs alone is not sufficient to reduce malaria morbidity and recommends that enlightenment and assistance with hanging of LLINs should form an integral part of mass distribution of LLINs by government and donor agencies