THE EVALUATION OF REACTOGENICITY, SAFETY AND IMMUNOGENICITY OF THE POLYSACCHARIDE PNEUMOCOCCAL VACCINE DURING THE IMMUNIZATION OF HEALTH CARE WORKERS

Abstract. The article presents results of a prospective randomized study of reactogenicity, safety and immunogenicity of the polysaccharide pneumococcal vaccine “Pneumo 23” in the group of medical workers. The vaccine was characterized by the high profile of safety (absence of clinical symptoms of allergy, changes in blood and urine), low reactogenicity and sufficient immunogenicity

ИММУНОХРОМАТОГРАФИЧЕСКИЙ МЕТОД В ДИАГНОСТИКЕ ПНЕВМОКОККОВЫХ ЗАБОЛЕВАНИЙ РЕСПИРАТОРНОГО ТРАКТА

Streptococcus pneumonia – one of the reasons for the appearance of complications from influenza and acute respiratory diseases, occurring with a lesion of ENT organs and respiratory system. In this regard, there is a substantial need for the use of additional methods of laboratory testing for verification of pathogen. Diagnostics of complications from respiratory diseases caused by pneumococcal flora has been carried out by immunochromatographic assay. Microbiological examination revealed the pneumococcal etiology of complications only in 14,0% of cases, but verification of diagnosis by detection of Streptococcus pneumonia antigen in the urine in 29,8%.Streptococcus pneumonia – одна из причин возникновения осложнений при гриппе и острых респираторных заболеваниях, протекающих с поражением ЛОР- органов и дыхательной системы. В связи с этим возникает существенная необходимость использования дополнительных методов лабораторного исследования для верификации возбудителя. Проведена диагностика осложнений респираторных заболеваний, вызванных пневмококковой флорой, с помощью иммунохроматографического анализа. Микробиологическое исследование позволило выявить пневмококковую этиологию осложнений только в 14,0% случаев, а верификация диагноза  утем определения антигена Streptococcus pneumonia в моче –в 29,8%

Immunochromatographic method in the diagnosis of pneumococcal respiratory tract diseases

Streptococcus pneumonia – one of the reasons for the appearance of complications from influenza and acute respiratory diseases, occurring with a lesion of ENT organs and respiratory system. In this regard, there is a substantial need for the use of additional methods of laboratory testing for verification of pathogen. Diagnostics of complications from respiratory diseases caused by pneumococcal flora has been carried out by immunochromatographic assay. Microbiological examination revealed the pneumococcal etiology of complications only in 14,0% of cases, but verification of diagnosis by detection of Streptococcus pneumonia antigen in the urine in 29,8%

Evaluation of the Reactogenicity, Safety and Immunogenicity of the Domestic Influenza Inactivated Split FLU-M Vaccine in Immunization Adults aged 18–60 Years

This article presents the results of a simple, blind, randomized, placebo-controlled, single-center, prospective research of the reactogenicity, safety, and immunogenicity of the domestic influenza inactivated split vaccine «Flu-M» in immunization of the adult population of 18–60 years old. Low reactogenicity, high safety profile and immunogenicity of the Flu-M vaccine were determined