A novel anomaly behavior detection scheme for mobile ad hoc networks

To sustain the security services in a Mobile Ad Hoc Networks (MANET), applications in terms of confidentially, authentication, integrity, authorization, key management, and abnormal behavior detection/anomaly detection are significant. The implementation of a sophisticated security mechanism requires a large number of network resources that degrade network performance. In addition, routing protocols designed for MANETs should be energy efficient in order to maximize network performance. In line with this view, this work proposes a new hybrid method called the data-driven zone-based routing protocol (DD-ZRP) for resource-constrained MANETs that incorporate anomaly detection schemes for security and energy awareness using Network Simulator 3. Most of the existing schemes use constant threshold values, which leads to false positive issues in the network. DD-ZRP uses a dynamic threshold to detect anomalies in MANETs. The simulation results show an improved detection ratio and performance for DD-ZRP over existing schemes; the method is substantially better than the prevailing protocols with respect to anomaly detection for security enhancement, energy efficiency, and optimization of available resources

Progressive hypertension and severe left ventricular outflow tract obstruction

No abstract available

Rapidity distribution as a probe for elliptical flow at intermediate energies

Interplay between the spectator and participant matter in heavy-ion collisions is investigated within isospin dependent quantum molecular dynamics (IQMD) model in term of rapidity distribution of light charged particles. The effect of different types and size rapidity distributions is studied in elliptical flow. The elliptical flow patterns show important role of the nearby spectator matter on the participant zone. This role is further explained on the basis of passing time of the spectator and expansion time of the participant zone. The transition from the in-plane to out-of-plane is observed only when the mid-rapidity region is included in the rapidity bin, otherwise no transition occurs. The transition energy is found to be highly sensitive towards the size of the rapidity bin, while weakly on the type of the rapidity distribution. The theoretical results are also compared with the experimental findings and are found in good agreement.Comment: 8 figure

The global impact of tobacco control policies on smokeless tobacco use: a systematic review

BACKGROUND: Smokeless tobacco, used by more than 300 million people globally, results in substantial morbidity and mortality. For smokeless tobacco control, many countries have adopted policies beyond the WHO Framework Convention on Tobacco Control, which has been instrumental in reducing smoking prevalence. The impact of these policies (within and outside the Framework Convention on Tobacco Control) on smokeless tobacco use remains unclear. We aimed to systematically review policies that are relevant to smokeless tobacco and its context and investigate their impact on smokeless tobacco use. METHODS: In this systematic review, we searched 11 electronic databases and grey literature between Jan 1, 2005, and Sept 20, 2021, in English and key south Asian languages, to summarise smokeless tobacco policies and their impact. Inclusion criteria were all types of studies on smokeless tobacco users that mentioned any smokeless tobacco relevant policies since 2005, except systematic reviews. Policies issued by organisations or private institutions were excluded as well as studies on e-cigarettes and Electronic Nicotine Delivery System except where harm reduction or switching were evaluated as a tobacco cessation strategy. Two reviewers independently screened articles, and data were extracted after standardisation. Quality of studies was appraised using the Effective Public Health Practice Project's Quality Assessment Tool. Outcomes for impact assessment included smokeless tobacco prevalence, uptake, cessation, and health effects. Due to substantial heterogeneity in the descriptions of policies and outcomes, data were descriptively and narratively synthesised. This systematic review was registered in PROSPERO (CRD42020191946). FINDINGS: 14 317 records were identified, of which 252 eligible studies were included as describing smokeless tobacco policies. 57 countries had policies targeting smokeless tobacco, of which 17 had policies outside the Framework Convention on Tobacco Control for smokeless tobacco (eg, spitting bans). 18 studies evaluated the impact, which were of variable quality (six strong, seven moderate, and five weak) and reported mainly on prevalence of smokeless tobacco use. The body of work evaluating policy initiatives based on the Framework Convention on Tobacco Control found that these initiatives were associated with reductions in smokeless tobacco prevalence of between 4·4% and 30·3% for taxation and 22·2% and 70·9% for multifaceted policies. Two studies evaluating the non-Framework policy of sales bans reported significant reductions in smokeless tobacco sale (6·4%) and use (combined sex 17·6%); one study, however, reported an increased trend in smokeless tobacco use in the youth after a total sales ban, likely due to cross-border smuggling. The one study reporting on cessation found a 13·3% increase in quit attempts in individuals exposed (47·5%) to Framework Convention on Tobacco Control policy: education, communication, training, and public awareness, compared with non-exposed (34·2%). INTERPRETATION: Many countries have implemented smokeless tobacco control policies, including those that extend beyond the Framework Convention on Tobacco Control. The available evidence suggests that taxation and multifaceted policy initiatives are associated with meaningful reductions in smokeless tobacco use. FUNDING: UK National Institute for Health Research

Myricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function

The aberrant misfolding and self-assembly of human islet amyloid polypeptide (hIAPP)–a hormone that is co-secreted with insulin from pancreatic β-cells–into toxic oligomers, protofibrils and fibrils has been observed in type 2 diabetes mellitus (T2DM). The formation of these insoluble aggregates has been linked with the death and dysfunction of β-cells. Therefore, hIAPP aggregation has been identified as a therapeutic target for T2DM management. Several natural products are now being investigated for their potential to inhibit hIAPP aggregation and/or disaggregate preformed aggregates. In this study, we attempt to identify the anti-amyloidogenic potential of Myricetin (MYR)- a polyphenolic flavanoid, commonly found in fruits (like Syzygium cumini). Our results from biophysical studies indicated that MYR supplementation inhibits hIAPP aggregation and disaggregates preformed fibrils into non-toxic species. This protection was accompanied by inhibition of oxidative stress, reduction in lipid peroxidation and the associated membrane damage and restoration of mitochondrial membrane potential in INS-1E cells. MYR supplementation also reversed the loss of functionality in hIAPP exposed pancreatic islets via restoration of glucose-stimulated insulin secretion. Molecular dynamics simulation studies suggested that MYR molecules interact with the hIAPP pentameric fibril model at the amyloidogenic core region and thus prevents aggregation and distort the fibrils.Council of Scientific and industrial research, Government of India (RD/0111-CSIR000-016) and Indian Institute of Technology, Bombay (11IRCCSG003); Wadhwani Research Center of Bioengineering (RD/018/- DONWR04-001/); Ramalingaswami fellowship (BT/RLF/Re-entry/11/2012; Department of Biotechnology-DBT, Government of India); and University Grants Commission (UGC, Government of India F.4-5(18-FRP) (IV-Cycle)/2017(BSR)

Convergence and stability theorems for the Picard-Mann hybrid iterative scheme for a general class of contractive-like operators

In this paper we use the general class of contractive-like operators introduced by Bosede and Rhoades (J. Adv. Math. Stud. 3(2):1-3, 2010) to prove strong convergence and stability results for Picard-Mann hybrid iterative schemes considered in a real normed linear space. We establish the strong convergence and stability of the Picard iterative scheme as a corollary. Our results generalize and improve a multitude of results in the literature, including the recent results of Chidume (Fixed Point Theory Appl. 2014:233, 2014)