Diisopropyl 1-(4-meth­oxy­phen­yl)-2,6-dimethyl-4-(3-nitro­phen­yl)-1,4-dihydro­pyridine-3,5-dicarboxyl­ate

In the title compound, C28H32N2O7, the 1,4-dihydro­pyridine ring adopts a flattened boat conformation. The two benzene rings are approximately perpendicular to the dihydro­pyridine ring, forming dihedral angles of 84.29 (9) and 82.96 (9)° with the mean plane of the 1,4-dihydro­pyridine unit, whereas the ester groups are only slightly twisted relative to this plane, with dihedral angles of 10.6 (1) and 9.0 (1)°

Intramolecular addition of a hydroxyl to a N-acyliminium system. Application to the synthesis of isoindolo[2,1-a][3,1]benzoxazine and isoindolo[1,2-c][2,4] benzoxazepine derivatives

International audienceThe titled compounds were prepared by the reaction of hydroxylated lactam (3a-c) or (10) with p-toluenesulfonic acid in dichloromethane. The ratio of diastereomeric mixtures (4b/5b (2/1) or 4c/5c (2/1) or 11/12 (5/1)) is discussed