21,629 research outputs found
On Lerch's transcendent and the Gaussian random walk
Let be independent variables, each having a normal distribution
with negative mean and variance 1. We consider the partial sums
, with , and refer to the process as
the Gaussian random walk. We present explicit expressions for the mean and
variance of the maximum These expressions are in terms
of Taylor series about with coefficients that involve the Riemann
zeta function. Our results extend Kingman's first-order approximation [Proc.
Symp. on Congestion Theory (1965) 137--169] of the mean for .
We build upon the work of Chang and Peres [Ann. Probab. 25 (1997) 787--802],
and use Bateman's formulas on Lerch's transcendent and Euler--Maclaurin
summation as key ingredients.Comment: Published at http://dx.doi.org/10.1214/105051606000000781 in the
Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute
of Mathematical Statistics (http://www.imstat.org
Finite-size scaling of directed percolation above the upper critical dimension
We consider analytically as well as numerically the finite-size scaling
behavior in the stationary state near the non-equilibrium phase transition of
directed percolation within the mean field regime, i.e., above the upper
critical dimension. Analogous to equilibrium, usual finite-size scaling is
valid below the upper critical dimension, whereas it fails above. Performing a
momentum analysis of associated path integrals we derive modified finite-size
scaling forms of the order parameter and its higher moments. The results are
confirmed by numerical simulations of corresponding high-dimensional lattice
models.Comment: 4 pages, one figur
Optimal Tradeoff Between Exposed and Hidden Nodes in Large Wireless Networks
Wireless networks equipped with the CSMA protocol are subject to collisions
due to interference. For a given interference range we investigate the tradeoff
between collisions (hidden nodes) and unused capacity (exposed nodes). We show
that the sensing range that maximizes throughput critically depends on the
activation rate of nodes. For infinite line networks, we prove the existence of
a threshold: When the activation rate is below this threshold the optimal
sensing range is small (to maximize spatial reuse). When the activation rate is
above the threshold the optimal sensing range is just large enough to preclude
all collisions. Simulations suggest that this threshold policy extends to more
complex linear and non-linear topologies
Exploring prospects of novel drugs for tuberculosis
Tuberculosis remains a disease with an enormous impact on public health worldwide. With the continuously increasing epidemic of drug-resistant tuberculosis, new drugs are desperately needed. However, even for the treatment of drug-sensitive tuberculosis, new drugs are required to shorten the treatment duration and thereby prevent development of drug resistance. Within the past ten years, major advances in tuberculosis drug research have been made, leading to a considerable number of antimycobacterial compounds which are now in the pipeline. Here we discuss a number of these novel promising tuberculosis drugs, as well as the discovery of two new potential drug targets for the development of novel effective drugs to curb the tuberculosis pandemic, ie, the coronin 1 and protein kinase G pathways. Protein kinase G is secreted by mycobacteria and is responsible for blocking lysosomal delivery within the macrophage. Coronin 1 is responsible for activating the phosphatase, calcineurin, and thereby preventing phagosome-lysosome fusion within the macrophage. Blocking these two pathways may lead to rapid killing of mycobacteri
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