Control of brain blood flow by capillaries: a simulation study in an anatomically accurate large human vascular network

In this paper, the variations in cerebral blood flow induced by global or localised capillary vasodilations are studied. The results demonstrate that pericyte-mediated regulation of blood flowat capillary level would be efficient for neuro-vascular coupling. By contrast to a regulation situated at the level of arterioles (Lorthois et al. 2011b), the changes in blood volume can be highly localised in space, with the potential to be as close as possible of areas of neuronal activation. However, the changes in blood flow are much more diffuse. This imposes limits on the ultimate spatial resolution of hemodynamically based brain functional imaging techniques

Goldstone Bosons in Josephson Junctions

For a microscopic model of a Josephson junction the normal coordinates of the two junction Goldstone bosons are constructed and their dynamical spectrum is computed. The explicit dependence on the phase difference of the two superconductors is calculated

Growth and diagenesis of cryptalgal-bryozoan buildups within a Mid-Visean (Dinantian) cyclic sequence, Belgium

Cryptalgal-bryozoan carbonate buildups are reported from the Middle Visean (Upper Dinantian) near Namur, Belgium. They occur in a 20 m-thick, upward-shallowing, carbonate rhythm - the thickest in a succession of such rhythms.The rhythm comprises three phases; from bottom to top: (1) packstones-grainstones with rich and diverse biota, indicating open, shallow marine conditions; grading to (2) wackestones, with a poorer and more restricted biota, passing upwards to cryptalgal boundstones; and(3) mudstones with highly restricted and reduced biota.Small- to medium- sized mounds (2-11 m thick) occur at the top of Phase 2 where they established on coral thickets. The buildups consist of a meshwork of bryozoans encrusted by finely laminated cryptalgal coatings and encrusting bryozoans. Brachiopods, sponges and vermetid gastropods are also present. Voids were filled by internal sediments and early marine cements. The growth of the buildups was probably interrupted by a short-lived sea-level drop, recorded laterally as what seems to be a karstic surface. Vadose internal sedimentation and minor leaching by meteoric water occurred in the ?exposed buildups. Marine conditions were then restored and, at the beginning of Phase 3 deposition, coral thickets (with cryptalgal coatings) colonized the top of the largest buildup. Most remaining pore space was filled by burial cements. Other minor diagenetic processes include neomorphism, dolomitization, precipitation of Ca-sulphates and silicification

Spectrum of the Dirac Operator and Multigrid Algorithm with Dynamical Staggered Fermions

Complete spectra of the staggered Dirac operator \Dirac are determined in quenched four-dimensional $SU(2)$ gauge fields, and also in the presence of dynamical fermions. Periodic as well as antiperiodic boundary conditions are used. An attempt is made to relate the performance of multigrid (MG) and conjugate gradient (CG) algorithms for propagators with the distribution of the eigenvalues of~\Dirac. The convergence of the CG algorithm is determined only by the condition number~$\kappa$ and by the lattice size. Since~$\kappa$'s do not vary significantly when quarks become dynamic, CG convergence in unquenched fields can be predicted from quenched simulations. On the other hand, MG convergence is not affected by~$\kappa$ but depends on the spectrum in a more subtle way.Comment: 19 pages, 8 figures, HUB-IEP-94/12 and KL-TH 19/94; comes as a uuencoded tar-compressed .ps-fil

Cost-benefit analysis of abatement measures for nutrient emission from agriculture

In intensive animal husbandry areas surface water N and P concentrations often remain too high. The Water Framework Directive calls for additional nutrient emission abatement measures. Therefore, costs and benefits for possible agricultural measures in Flanders were first analysed in terms of soil balance surplus. Finally, abatement measures for agriculture, households and industry were set off against each other and ranked according to their cost-efficiency by the Environmental Costing Model. Increased dairy cattle efficiency, winter cover crops and increased pig feed efficiency turn out very cost efficient. Other agricultural measures are less cost efficient than for instance collective treatment for households and industry.nitrogen and phosphorus abatement, surface water, cost efficiency, Environmental Economics and Policy, Livestock Production/Industries,

Optimising finishing pig delivery weight : participatory decision problem analysis

The seemingly straightforward question of optimal pig delivery weight is more complex than meets the eye. Despite abundant research insights, the industry continues to request additional applied scientific decision support on the delivery weight problem. The current objective is to investigate whether and how the complex decision of delivery weight can be reshaped (reframed) into a more tangible and comprehensible system of factors that matter for making the right decision. We used a participatory decision problem analysis, which resulted in modelling blueprints that incorporate factors prioritised by stakeholders for determining optimal delivery weights. How to efficiently organise such a 'problem reframing process' is case-specific: it depends on the objective, the initial problem understanding by the stakeholders, and their learning potential. Efficient co-learning is a prerequisite for successful participatory problem analysis. Our study reveals that the first step in such a process of 'problem reframing' should therefore be to answer the question of how to effectively organise co-learning among stakeholders and researchers, instead of starting with a correct and detailed representation of the problem. Useful guidelines for participatory problem reframing processes are (1) providing sufficient participatory learning steps, (2) having few and clearly defined objectives per learning step, (3) providing adapted learning tools per step, (4) establishing a common language and (5) deliberately choosing stakeholders based on prior knowledge of the problem or its context, potential motivation or incentives to be part of the participatory process step and potential role in up-scaling the co-learning process to a larger group of beneficiaries

Determining Mortality Rates Attributable to Clostridium difficile Infection

To determine accuracy of measures of deaths attributable to Clostridium difficile infection, we compared 3 measures for 2007–2008 in Ontario, Canada: death certificate; death within 30 days of infection; and panel review. Data on death within 30 days were more feasible than panel review and more accurate than death certificate data

Deep sternal wound infection after open heart surgery: current treatment insights. A retrospective study of 36 cases

The aim of this study was to retrospectively evaluate the results of reconstructing infected post-sternotomy wounds, with either sternal plating and/or pectoralis major flap transposition or pedicled omentoplasty after previous vacuum-assisted closure (VAC) therapy. Between January 2005 and December 2010, 36 patients, suffering from deep sternal wound infection (DSWI) after coronary artery bypass grafting procedure, received (plastic) reconstructive surgery. All patients, treated in the Maastricht University Medical Centre (Departments of Plastic Surgery and Cardiothoracic Surgery), were selected for this study. For 22 patients, sternal refixation and reconstruction were obtained by sternal internal plate fixation combined with bilateral pectoralis major advancement flap. In 11 patients, a pedicled omentoplasty was performed, with or without split-skin graft and additional VAC therapy. Three patients only received a pectoralis plasty. We evaluated preoperative characteristics and post-operative course. Twenty-four patients (66.7%) had an uneventful post-operative course. Complications in the other patients included wound dehiscence, herniation of the donor site and infection of sternal plating material. Average sternal wound healing after sternal plating plus pectoralis plasty, pectoralis plasty and omentoplasty respectively accounted 7.7, 8.0 and 11.6 weeks. From our experience, we recommend VAC therapy plus delayed sternal plating and additional bilateral pectoralis major flap advancement as first repair option in case of DSWI. However, individual clinical conditions need to be taken into account when making a decision between the different available reconstructive options. Omentoplasty should be reserved for cases in which the sternum has recurrently fallen open after previous sternal plate refixation, or for cases in which the sternum defect is too extended