Developmental Expression of Elements of Hepatic Cholesterol Metabolism In The Rat

The expression of several key enzymes and receptors of rat hepatic cholesterol metabolism was studied during development. Among major findings were: acyl coenzyme A:cholesterol acyltransferase, the cholesteryl ester hydrolases, cholesterol-7 alpha-hydroxylase and the alpha 2-macroglobulin receptor (LRP) were very low in fetal livers, but all were induced shortly before birth, suggesting that these elements are important for extrauterine life. Although the other elements continued to increase, by day 6 of postnatal life, cholesterol-7 alpha-hydroxylase had reached undetectable levels. It reappeared by day 12 of suckling, placing it in the group of late-appearing activities necessary for the fully mature hepatic phenotype. Changes in acyl coenzyme A:cholesterol acyltransferase activity appeared due predominantly to changes in amount of active protein. The cholesteryl ester hydrolase (CEH) activities all showed different developmental patterns, suggesting that each was a unique activity. The bile salt- dependent CEH activity was much higher in the suckling period than in the adult where it was almost undetectable, suggesting that this CEH may have its major importance in the suckling period of development. Low density lipoprotein receptors exhibited a pattern very different from that of the alpha 2-macroglobulin receptors and did not show consistent correlation with any other elements. At some developmental time points, the relationships amongst the elements differed significantly from the adult pattern. These studies provide for the first time an integrated picture of developmental expression of key elements of hepatic cholesterol metabolism and set the stage for further studies on their modes of regulation

An Error-Components Three-Stage Least-Squares Model of Investment Allocation by Farm Households

This paper is an assessment of patterns of investment by farm households via an econometric model adapted from a land allocation approach of Holt (1999). This analysis will shed light on the importance of different classes of assets to farm household well-being, and show the reaction of farm households to a variety of market, international and government effects.Farm Management,

A neutron scattering study of the interplay between structure and magnetism in Ba(Fe1−x_{1-x}Cox_{x})2_2As2_2

Single crystal neutron diffraction is used to investigate the magnetic and structural phase diagram of the electron doped superconductor Ba(Fe$_{1-x}$Co$_x$)$_2$As$_2$. Heat capacity and resistivity measurements have demonstrated that Co doping this system splits the combined antiferromagnetic and structural transition present in BaFe$_2$As$_2$ into two distinct transitions. For $x$=0.025, we find that the upper transition is between the high-temperature tetragonal and low-temperature orthorhombic structures with ($T_{\mathrm{TO}}=99 \pm 0.5$ K) and the antiferromagnetic transition occurs at $T_{\mathrm{AF}}=93 \pm 0.5$ K. We find that doping rapidly suppresses the antiferromagnetism, with antiferromagnetic order disappearing at $x \approx 0.055$. However, there is a region of co-existence of antiferromagnetism and superconductivity. The effect of the antiferromagnetic transition can be seen in the temperature dependence of the structural Bragg peaks from both neutron scattering and x-ray diffraction. We infer from this that there is strong coupling between the antiferromagnetism and the crystal lattice

Verbal learning and memory in agenesis of the corpus callosum

The role of interhemispheric interactions in the encoding, retention, and retrieval of verbal memory can be clarified by assessing individuals with complete or partial agenesis of the corpus callosum (AgCC), but who have normal intelligence. This study assessed verbal learning and memory in AgCC using the California Verbal Learning Test—Second Edition (CVLT-II). Twenty-six individuals with AgCC were compared to 24 matched controls on CVLT-II measures, as well as Donders׳ four CVLT-II factors (i.e., Attention Span, Learning Efficiency, Delayed Memory, and Inaccurate Memory). Individuals with AgCC performed significantly below healthy controls on the Delayed Memory factor, confirmed by significant deficits in short and long delayed free recall and cued recall. They also performed less well in original learning. Deficient performance by individuals with AgCC during learning trials, as well as deficits in all forms of delayed memory, suggest that the corpus callosum facilitates interhemispheric elaboration and encoding of verbal information

Evidence for nodal superconductivity in LaFePO

In several iron-arsenide superconductors there is strong evidence for a fully gapped superconducting state consistent with either a conventional s-wave symmetry or an unusual $s_\pm$ state where there the gap changes sign between the electron and hole Fermi surface sheets. Here we report measurements of the penetration depth $\lambda(T)$ in very clean samples of the related iron-phosphide superconductor, LaFePO, at temperatures down to $\sim$ 100 mK. We find that $\lambda(T)$ varies almost perfectly linearly with $T$ strongly suggesting the presence of gap nodes in this compound. Taken together with other data, this suggests the gap function may not be generic to all pnictide superconductors

Modelling the Role of Active Biomass on the Fate and Transport of a Heavy Metal in the Presence of Root Exudates

The influence of active biomass in immobilizing heavy metals in the soil rhizosphere is investigated through mechanistic models. The movement of water in the soil is modeled using Richards equation. An advection-dispersion equation, with a sink term for metal uptake by biomass, is used for modeling the fate and transport of lead. This sink term represents the nonlinear kinetics of metal adsorption to the biomass that is partitioned into mobile and stationary fractions within the soil. Transport of the mobile biomass fraction is modeled by an advection-dispersion equation, with a source term that is based on Monod growth kinetics, and a linear sink term for endogenous decay. The movement of metal in association with mobile biomass is also included as a transport mechanism for lead. Root exudates serve as carbon substrate for the biomass growth, and their transport is modeled in a similar way as that of the biomass. A hypothetical one-dimensional vertical soil column containing metal, biomass and a carbon substrate is used for analyzing lead movement. Model simulations demonstrate the influence of water content, growth rate of biomass, partitioning coefficient of biomass between soil and aqueous phase, and partitioning coefficient of metal between biomass and aqueous phase of the soil on fate and transport of lead. The extent of immobilization of lead in soil is found to be dependent on the growth of biomass, which in turn depends on the availability of root exudates in the rhizosphere. Apart from analyzing different scenarios, such a model can be used for designing future experiments

Precise calibration of LIGO test mass actuators using photon radiation pressure

Precise calibration of kilometer-scale interferometric gravitational wave detectors is crucial for source localization and waveform reconstruction. A technique that uses the radiation pressure of a power-modulated auxiliary laser to induce calibrated displacements of one of the ~10 kg arm cavity mirrors, a so-called photon calibrator, has been demonstrated previously and has recently been implemented on the LIGO detectors. In this article, we discuss the inherent precision and accuracy of the LIGO photon calibrators and several improvements that have been developed to reduce the estimated voice coil actuator calibration uncertainties to less than 2 percent (1-sigma). These improvements include accounting for rotation-induced apparent length variations caused by interferometer and photon calibrator beam centering offsets, absolute laser power measurement using temperature-controlled InGaAs photodetectors mounted on integrating spheres and calibrated by NIST, minimizing errors induced by localized elastic deformation of the mirror surface by using a two-beam configuration with the photon calibrator beams symmetrically displaced about the center of the optic, and simultaneously actuating the test mass with voice coil actuators and the photon calibrator to minimize fluctuations caused by the changing interferometer response. The photon calibrator is able to operate in the most sensitive interferometer configuration, and is expected to become a primary calibration method for future gravitational wave searches.Comment: 13 pages, 6 figures, accepted by Classical and Quantum Gravit