Potential for Higgs Physics at the LHC and Super-LHC

The expected sensitivity of the LHC experiments to the discovery of the Higgs boson and the measurement of its properties is presented in the context of both the standard model and the its minimal supersymmetric extension. Prospects for a luminosity-upgraded ``Super-LHC'' are also presented.Comment: Invited talk at 2005 International Linear Collider Physics and Detector Workshop and Second ILC Accelerator Workshop, Snowmass, CO(Snowmass05) 3 pages, 0 figures. PSN ALCPG060

Multivariate Analysis from a Statistical Point of View

Multivariate Analysis is an increasingly common tool in experimental high energy physics; however, many of the common approaches were borrowed from other fields. We clarify what the goal of a multivariate algorithm should be for the search for a new particle and compare different approaches. We also translate the Neyman-Pearson theory into the language of statistical learning theory.Comment: Talk from PhyStat2003, Stanford, Ca, USA, September 2003, 4 pages, LaTeX, 1 eps figures. PSN WEJT00

Frequentist Hypothesis Testing with Background Uncertainty

We consider the standard Neyman-Pearson hypothesis test of a signal-plus-background hypothesis and background-only hypothesis in the presence of uncertainty on the background-only prediction. Surprisingly, this problem has not been addressed in the recent conferences on statistical techniques in high-energy physics -- although the its confidence-interval equivalent has been. We discuss the issues of power, similar tests, coverage, and ordering rules. The method presented is compared to the Cousins-Highland technique, the ratio of Poisson means, and ``profile'' method.Comment: Talk from PhyStat2003, Stanford, Ca, USA, September 2003, 4 pages, LaTeX, 2 eps figures. PSN WEMT00

Transmission eigenvalues and thermoacoustic tomography

The spectrum of the interior transmission problem is related to the unique determination of the acoustic properties of a body in thermoacoustic imaging. Under a non-trapping hypothesis, we show that sparsity of the interior transmission spectrum implies a range separation condition for the thermoacoustic operator. In odd dimension greater than or equal to three, we prove that the transmission spectrum for a pair of radially symmetric non-trapping sound speeds is countable, and conclude that the ranges of the associated thermoacoustic maps have only trivial intersection

Genome Sequence of Kurthia Type Species Kurthia zopfii Strain ATCC 33403T

The genome of the type strain of the Kurthia genus, Kurthia zopfii ATCC 33403, was sequenced. Nonpathogenic K. zopfii has been isolated from intestinal contents, fecal material, meats, meat products, milk, water, and air, including air at high altitudes. The predicted genome size is 2,878,279 bp, with 37.05% G+C content

Treating hepatic steatosis and fibrosis by modulating mitochondrial pyruvate metabolism

A hepatic comorbidity of metabolic syndrome, known as nonalcoholic fatty liver disease (NAFLD), is increasing in prevalence in conjunction with the pandemics of obesity and diabetes. The spectrum of NAFLD ranges from simple hepatic fat accumulation to a more severe disease termed nonalcoholic steatohepatitis (NASH), involving inflammation, hepatocyte death, and fibrosis. Importantly, NASH is linked to a much higher risk of cirrhosis, liver failure, and hepatocellular carcinoma, as well as an increased risk for nonhepatic malignancies and cardiovascular disease. Interest in the understanding of the disease processes and search for treatments for the spectrum of NAFLD-NASH has increased exponentially, but there are no approved pharmacologic therapies. In this review, we discuss the existing literature supporting insulin-sensitizing thiazolidinedione compounds as potential drug candidates for the treatment of NASH. In addition, we put these results into new context by summarizing recent studies suggesting these compounds alter mitochondrial metabolism by binding and inhibiting the mitochondrial pyruvate carrier. Keywords: Nonalcoholic Steatohepatitis, Mitochondria, Pyruvate, Thiazolidinedion

Complete Genome Sequence of Staphylococcus epidermidis ATCC 12228 Chromosome and Plasmids Generated by Long-Read Sequencing

Staphylococcus epidermidis ATCC 12228 was sequenced using a long-read method to generate a complete genome sequence, including some plasmid sequences. Some differences from the previously generated short-read sequence of this nonpathogenic and non-biofilm-forming strain were noted. The assembly size was 2,570,371 bp with a total G+C% content of 32.08%