SOME ASPECTS OF EFFECTIVENESS AND SAFETY OF ANTIBACTERIAL DRUGS IN PREGNANCY

Analysis of published data on clinical effectiveness and safety of antimicrobial drugs indicates that original and generic antibacterial medicines sometimes significantly differ in the therapeutic equivalence and in the frequency and severity of side effects

Nanоbiocomposite based on dihydroquercetin and arabinogalactan in the form of a gel for external use as a means for the treatment of chronic venous insufficiency in an experiment

Background. Due to the high prevalence of chronic venous insufficiency among the population, with a decrease in the quality of life of patients and their early disability, there is a need to develop modern effective and safe means for the prevention and treatment of this pathology. We have developed the optimal composition and technology of a gel for external use based on a nanobiocomposite of dihydroquercetin and arabinogalactan, which has a venoprotective effect. The article presents data on the results of a preclinical study of the safety and specific activity of the gel.The aim. To study the specific activity (decongestant, antitranssudative action) and safety of a gel for external use based on nanobiocomposite of dihydroquercetin and arabinogalactan used for the treatment of chronic venous insufficiency in the framework of preclinical studies.Materials and methods. The object of the study was a gel for external use based on dihydroquercetin and arabinogalactan nanobiocomposite. The study was conducted on 32 white male rats of the same age, for 15 days. The study of the pharmacological activity of a gel based on a nanobiocomposite of dihydroquercetin and arabinogalactan, was carried out on a model of acute venous stagnation in the tail of a rat (edema of non-inflammatory genesis), the dynamics of tail volume growth in the experimental and control group of animals was evaluated. The irritant effect of the gel on the skin of animals was also determined, the permeability of the capillaries of the skin was determined.Results. When studying the pharmacological activity of the gel on a model of acute venous stagnation in the tail, it was shown that a soft dosage form for external use developed on the basis of nanobiocomposite of dihydroquercetin and arabinogalactan has decongestant and antitranssudative activity. The presence of a locally irritating effect in the gel under study has not been established in the framework of the experiment.Conclusion. In the course of preclinical study of the gel of the nanobiocomposite dihydroquercetin and arabinogalactan on laboratory animals, its antitranssudative activity and safety have been proven

Complex Structure of Lasiopodomys mandarinus vinogradovi Sex Chromosomes, Sex Determination, and Intraspecific Autosomal Polymorphism.

The mandarin vole, Lasiopodomys mandarinus, is one of the most intriguing species among mammals with non-XX/XY sex chromosome system. It combines polymorphism in diploid chromosome numbers, variation in the morphology of autosomes, heteromorphism of X chromosomes, and several sex chromosome systems the origin of which remains unexplained. Here we elucidate the sex determination system in Lasiopodomys mandarinus vinogradovi using extensive karyotyping, crossbreeding experiments, molecular cytogenetic methods, and single chromosome DNA sequencing. Among 205 karyotyped voles, one male and three female combinations of sex chromosomes were revealed. The chromosome segregation pattern and karyomorph-related reproductive performances suggested an aberrant sex determination with almost half of the females carrying neo-X/neo-Y combination. The comparative chromosome painting strongly supported this proposition and revealed the mandarin vole sex chromosome systems originated due to at least two de novo autosomal translocations onto the ancestral X chromosome. The polymorphism in autosome 2 was not related to sex chromosome variability and was proved to result from pericentric inversions. Sequencing of microdissection derived of sex chromosomes allowed the determination of the coordinates for syntenic regions but did not reveal any Y-specific sequences. Several possible sex determination mechanisms as well as interpopulation karyological differences are discussed

The history of the development of the method of rheography in the XX-XXI centuries

Article describes the main historical milestones in the development of the method of rheography from the moment of inception to the present day. The special place in article is a breakthrough research on various aspects of this method using the techniques of computer analysis of reogram. The article provides a summary of the biophysical basics of rheography and objectivity of its application for assessing physiological functions of the cardiovascular system, proved the value of rheography in the study of biomechanics of blood circulation. The article provides information on the methods of registration of rheogram, fixation of electrodes and data about the capabilities and prospects of application of the method of rheography to assess the function of endothelium and elastic properties of the arterial wall.Статья содержит основные исторические вехи развития метода реографии с момента возникновения до наших дней. Особое место в статье занимают прорывные исследования различных аспектов данного метода с применением техники компьютерного анализа реограмм. В статье приводится краткая информация о биофизических основах реографии и объективность ее применения для оценки физиологических функции сердечно-сосудистой системы, обосновано значение реографии в изучении биомеханики кровообращения. В статье содержится информация о методиках регистрации реограмм, способах фиксации электродов и данные о возможностях и перспективах применения метода реографии для оценки функции эндотелия и эластических свойств артериальной стенки

dominant as the basis for the plot of travel novels by K. D. Balmont

В статье рассматривается проявление автобиографического начала в путевых очерках К. Д. Бальмонта, его влияние на особенности нарратива, а также анализируется природа биографического факта и его сюжетообразующая роль в текстах писателя. В качестве объекта исследования выступают сборник путевых писем «В странах Солнца. Письма к частному лицу из кругосветного путешествия» и очерк «Океания».The article considers the manifestation of autobiography in the travel novels of K. D. Balmont, its influence on narrative features, and also consists an analysis of the nature of the biographical fact and its storyline-forming role in the writer’s texts. The object of the study is a collection of travel novels “In the Lands of the Sun. Letters to the private person from around-the-world trip” and “Oceania”

(-)-SCLAREOL CONVERSION IN RITTER'S REACTION CONDITIONS

The main products of sclareol (1) Ritter’s reaction in mild conditions are (8R,13R)-Labd-14(15)-en-8,13-diacetamide (2) (8R,13S)-Labd-14(15)-en-8,13-diacetamide (3) stereoisomeric on C13 atom and having unrearranged native diol skeleton. We present in the current communication the results of sclareol converting (1) into nitrogen-containing labdanes in the Ritter’s reaction conditions