Analysis of Construction Fall Protection Guardrails in a Population with Changing Anthropometrics

The construction trade has commonly been cited as one of the most dangerous industries within the United States, with falls from elevation being the most predominate cause for injuries and deaths. The OSHA standards related guardrails has not changed since its implementation in 1970. These standards originally derive from the 1950s, which expect a 160-pound person with 40 pounds of equipment, tools, etc. However, the anthropometries of the common working age citizen has dramatically changed in respects to their weight. This study examines the relationship of the guardrail system to the changing anthropometries to determine if a reform is necessary for the [1926.502] Guardrail System as a form of fall protection is needed

Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause.

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement for codriver mutations in APAs. Here we identified gain-of-function mutations in both CTNNB1 and GNA11 by whole-exome sequencing of 3/41 APAs. Further sequencing of known CTNNB1-mutant APAs led to a total of 16 of 27 (59%) with a somatic p.Gln209His, p.Gln209Pro or p.Gln209Leu mutation of GNA11 or GNAQ. Solitary GNA11 mutations were found in hyperplastic zona glomerulosa adjacent to double-mutant APAs. Nine of ten patients in our UK/Irish cohort presented in puberty, pregnancy or menopause. Among multiple transcripts upregulated more than tenfold in double-mutant APAs was LHCGR, the receptor for luteinizing or pregnancy hormone (human chorionic gonadotropin). Transfections of adrenocortical cells demonstrated additive effects of GNA11 and CTNNB1 mutations on aldosterone secretion and expression of genes upregulated in double-mutant APAs. In adrenal cortex, GNA11/Q mutations appear clinically silent without a codriver mutation of CTNNB1

Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome

Sepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical bilayered proteolipids. Using a mouse model, we showed that intraperitoneal injection of OMVs derived from intestinal Escherichia coli induced lethality. Furthermore, OMVs induced host responses which resemble a clinically relevant condition like sepsis that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, and systemic induction of tumor necrosis factor-α and interleukin-6. Our study revealed a previously unidentified causative microbial signal in the pathogenesis of sepsis, suggesting OMVs as a new therapeutic target to prevent and/or treat severe sepsis caused by Gram-negative bacterial infection

Analysis of Construction Fall Protection Guardrails in a Population with Changing Anthropometrics

The construction trade has commonly been cited as one of the most dangerous industries within the United States, with falls from elevation being the most predominate cause for injuries and deaths. The OSHA standards related guardrails has not changed since its implementation in 1970. These standards originally derive from the 1950s, which expect a 160-pound person with 40 pounds of equipment, tools, etc. However, the anthropometries of the common working age citizen has dramatically changed in respects to their weight. This study examines the relationship of the guardrail system to the changing anthropometries to determine if a reform is necessary for the [1926.502] Guardrail System as a form of fall protection is needed