Preparing consolidated financial statements in accordance with IFRS

The article considers specifics of preparation of consolidated financial statements in Kazakhstan companies in accordance with international financial reporting standards.This article considers the features of the preparation of consolidated financial statements in Kazakhstani organizations in accordance with international financial reporting standards that are necessary to provide accurate and fair information on the economic activities of the Group. The IFRS reporting ensures more accurate assessment of the financial status of the company, its changes, the results of the Group’s performance, as well as it enables a greater independence of decision making.peer-reviewe

Development of Mathematical Models and Modelling of Chemical Technological Systems using Fuzzy-Output Systems

The paper proposes a systematic approach to the development of structured mathematical model and modelling of Chemical-Technological Systems (CTSs) of refinery under fuzzy conditions. Idea and novelty of the proposed method are based on the study of each unit of chemical-technological systems, and based on obtained results, the model of separate element of chemical-technological systems unit is designed. At the next stage, separately-developed models are combined into a single system to fully model the process. The developed method has been successfully implemented during the construction of models system of the basic reforming units of catalytic reforming at Atyrau oil refinery. Comparison of the known results and modelling results based on the proposed method demonstrates the effective realization for constructing a system of models for main units of sulfur production in Atyrau oil refinery

Peptide-conjugated nanoparticles for targeted photodynamic therapy

Cancer is the second leading cause of death worldwide after cardiovascular disease. Depending on the type and the location of the tumor, several cancer treatments are implemented. Among these, the three most conventional therapies are surgery, radiotherapy and chemotherapy. However, there are other therapeutic approaches such as photodynamic therapy (PDT). PDT relies on the combined action of light, a photoactivable molecule called photosensitizer (PS) and molecular oxygen. Most of the PSs used for clinical applications are not cancer-cell specific. One of the solutions to overcome this problem is the use of nanoparticles (NPs) to induce a passive targeting. It is also possible to graft a vector onto the NPs to specifically target membrane receptors overexpressed in the tumor cells or neovessels surrounding the tumor. In this review, we focus on the NPs loaded with PSs and coupled to peptides for targeted PDT. We described nanosystems that targeted Neuropilin-1 (NRP-1), alpha(v)beta(3) integrins, nucleolin membrane receptor, epidermal growth factor (EGF) receptor, protein-glutamine-gamma-glutamyltransferase (TGM2), p32, transferrin, PD-1, and mitochondrial membrane. The use of a cell absorbing-peptide is also described