Comparison of Post-injection Site Pain Between Technetium Sulfur Colloid and Technetium Tilmanocept in Breast Cancer Patients Undergoing Sentinel Lymph Node Biopsy.

BackgroundNo prior studies have examined injection pain associated with Technetium-99m Tilmanocept (TcTM).MethodsThis was a randomized, double-blinded study comparing postinjection site pain between filtered Technetium Sulfur Colloid (fTcSC) and TcTM in breast cancer lymphoscintigraphy. Pain was evaluated with a visual analogue scale (VAS) (0-100 mm) and the short-form McGill Pain Questionnaire (SF-MPQ). The primary endpoint was mean difference in VAS scores at 1-min postinjection between fTcSC and TcTM. Secondary endpoints included a comparison of SF-MPQ scores between the groups at 5 min postinjection and construction of a linear mixed effects model to evaluate the changes in pain during the 5-min postinjection period.ResultsFifty-two patients underwent injection (27-fTcSC, 25-TcTM). At 1-min postinjection, patients who received fTcSC experienced a mean change in pain of 16.8 mm (standard deviation (SD) 19.5) compared with 0.2 mm (SD 7.3) in TcTM (p = 0.0002). At 5 min postinjection, the mean total score on the SF-MPQ was 2.8 (SD 3.0) for fTcSC versus 2.1 (SD 2.5) for TcTM (p = 0.36). In the mixed effects model, injection agent (p < 0.001), time (p < 0.001) and their interaction (p < 0.001) were associated with change in pain during the 5-min postinjection period. The model found fTcSC resulted in significantly more pain of 15.2 mm (p < 0.001), 11.3 mm (p = 0.001), and 7.5 mm (p = 0.013) at 1, 2, and 3 min postinjection, respectively.ConclusionsInjection with fTcSC causes significantly more pain during the first 3 min postinjection compared with TcTM in women undergoing lymphoscintigraphy for breast cancer

Molecular astronomy of cool stars and sub-stellar objects

The optical and infrared spectra of a wide variety of `cool' astronomical objects including the Sun, sunspots, K-, M- and S-type stars, carbon stars, brown dwarfs and extrasolar planets are reviewed. The review provides the necessary astronomical background for chemical physicists to understand and appreciate the unique molecular environments found in astronomy. The calculation of molecular opacities needed to simulate the observed spectral energy distributions is discussed

Electromagnetic Scattering from Relativistic Bound States

The quasipotential formalism for elastic scattering from relativistic bound states is formulated based on the instant constraint in the Breit frame. The quasipotential electromagnetic current is derived from Mandelstam's five-point kernel and obeys a two-body Ward identity. Breit-frame wave functions are obtained directly by solving integral equations with nonzero total three-momentum, thus accomplishing a dynamical boost. Calculations of electron-deuteron elastic form factors illustrate the importance of the dynamical boost versus kinematic boosts of the rest frame wave functions.Comment: RevTeX 3.0 manuscript, 9 pages. UU-file is a single PostScript file of the manuscript including figures. U. MD PP #93-17

On the accuracy of the melting curves drawn from modelling a solid as an elastic medium

An ongoing problem in the study of a classical many-body system is the characterization of its equilibrium behaviour by theory or numerical simulation. For purely repulsive particles, locating the melting line in the pressure-temperature plane can be especially hard if the interparticle potential has a softened core or contains some adjustable parameters. A method is hereby presented that yields reliable melting-curve topologies with negligible computational effort. It is obtained by combining the Lindemann melting criterion with a description of the solid phase as an elastic continuum. A number of examples are given in order to illustrate the scope of the method and possible shortcomings. For a two-body repulsion of Gaussian shape, the outcome of the present approach compares favourably with the more accurate but also more computationally demanding self-consistent harmonic approximation.Comment: 25 pages, 7 figure

QU Carinae: a SNeIa progenitor?

Optical spectra obtained in 2006-07 of the nova-like cataclysmic variable QU Car are studied for radial velocities, line profiles, and line identifications. We are not able to confirm the reported 10.9 hr orbital period from 1982,partly because our sampling is not ideal for this purpose and also, we suspect, because our radial velocities are distorted by line profile changes due to an erratic wind. P-Cygni profiles are found in several of the emission lines, including those of C IV. Carbon lines are abundant in the spectra, suggesting a carbon enrichment in the doner star. The presence of [O III] 5007\AA and [N II] 6584\AA is likely due to a diffuse nebula in the vicinity of the system. The wind signatures in the spectra and the presence of nebular lines are in agreement with the accretion wind evolution scenario that has been suggested to lead to SNeIa. We argue that QU Car is a member of the V Sge subclass of CVs, and a possible SNeIa progenitor. It is shown that the recent light curve of QU Car has ~1 mag low states, similar to the light curve of V Sge, strengthening the connection of QU Car with V Sge stars, supersoft x-ray sources, and SNeIa progenitors.Comment: Accepted in the Astronomical Journal. 11 pages, 3 tables, 5 figure

Instant Two-Body Equation in Breit Frame

A quasipotential formalism for elastic scattering from relativistic bound states is based on applying an instant constraint to both initial and final states in the Breit frame. This formalism is advantageous for the analysis of electromagnetic interactions because current conservation and four momentum conservation are realized within a three-dimensional formalism. Wave functions are required in a frame where the total momentum is nonzero, which means that the usual partial wave analysis is inapplicable. In this work, the three-dimensional equation is solved numerically, taking into account the relevant symmetries. A dynamical boost of the interaction also is needed for the instant formalism, which in general requires that the boosted interaction be defined as the solution of a four-dimensional equation. For the case of a scalar separable interaction, this equation is solved and the Lorentz invariance of the three-dimensional formulation using the boosted interaction is verified. For more realistic interactions, a simple approximation is used to characterize the boost of the interaction.Comment: 20 pages in revtex 3, 3 figures. Fixed reform/tex errors

Comment on `Renormalization-Group Calculation of the Dependence on Gravity of the Surface Tension and Bending Rigidity of a Fluid Interface'

It is shown that the interface model introduced in Phys. Rev. Lett. 86, 2369 (2001) violates fundamental symmetry requirements for vanishing gravitational acceleration $g$, so that its results cannot be applied to critical properties of interfaces for $g\to 0$.Comment: A Comment on a recent Letter by J.G. Segovia-L\'opez and V. Romero-Roch\'{\i}n, Phys. Rev. Lett.86, 2369 (2001). Latex file, 1 page (revtex