Association of prior depressive symptoms and suicide attempts with subsequent victimisation - analysis of population-based data from the Adult Psychiatric Morbidity Survey

Background: Symptoms of mental disorder, particularly schizophrenia, predispose to victimisation. Much less is known about the relationship between depressive symptoms and later victimisation in the general population, the influence of these symptoms on types of subsequent victimisation, or the role of symptom severity. We investigated this in nationally representative data from the UK. Methods: Data were from the Adult Psychiatric Morbidity Survey 2007. Multivariable logistic regressions estimated association between: a. prior depressive symptoms, and b. prior depressive symptoms with suicide attempt, and types of more recent victimisation. Gender-specific associations were estimated using multiplicative interactions. Results: Prior depressive symptoms were associated with greater odds of any recent intimate partner violence (IPV), emotional IPV, sexual victimisation, workplace victimisation, any victimisation, and cumulative victimisation (adjusted odds ratio (aOR) for increasing types of recent victimisation: 1.47, 95% confidence interval (CI): 1.14, 1.89). Prior depressive symptoms with suicide attempt were associated with any recent IPV, emotional IPV, any victimisation, and cumulative victimisation (aOR for increasing types of recent victimisation: 2.33, 95%: 1.22, 4.44). Limitations: Self-reported recalled data on previous depressive symptoms, may have limited accuracy. Small numbers of outcomes for some comparisons resulted in imprecision of these estimates. Conclusion: Aside from severe mental illness such as schizophrenia, previous depressive symptoms in the general population are associated with greater subsequent victimisation. Men and women with prior depressive symptoms may be vulnerable to a range of types of victimisation, and may benefit from interventions to reduce this vulnerability

Comparative study between interlock nailing and dynamic compression plating in humerus diaphyseal fractures in its functional and surgical outcome

Background: The aim of the study was to analyse compare study between interlock nailing and dynamic compression plating in humerus diaphyseal fractures in its functional and surgical outcome. Methods: The 2019 to 2022, patients were randomly divided into two groups with the help of computer-generated coded envelopes, group A (humerus diaphyseal fractures treated with dynamic compression plating) and group B (humerus diaphyseal fractures treated with interlock nailing) with 20 patients in each group. Outcomes were evaluated based on operative time, blood loss, neurovascular deficit, surgical site infection, union, shoulder stiffness, constant Murley score, Mayo elbow performance index at 1 year of follow up. Results: On radiology as non-union and union, most common study participants show union, on follow up of 1 year constant Murley score and Mayo elbow performance index was calculated and constant Murley score was more in patients treated with dynamic compression plating, shoulder stiffness was more in patients treated with interlock nailing. However blood loss was more in patients treated with dynamic compression plating. Conclusions: The result of our study shows that interlock nailing is associated with less blood loss but it is associated with decreased shoulder function postoperatively and marked shoulder stiffness which is more than patients treated with dynamic compression plating. Hence dynamic compression plating should be considered gold standard for operative treatment of humerus shaft fracture

The luminosities, sizes and velocity dispersions of Brightest Cluster Galaxies: Implications for formation history

The size-luminosity relation of early-type Brightest Cluster Galaxies (BCGs), R_e ~ L^0.88, is steeper than that for the bulk of the early-type galaxy population, for which R_e ~ L^0.68. In addition, although BCGs are hardly offset from the Fundamental Plane defined by the bulk of the early-type population, they show considerably smaller scatter. The larger than expected sizes of BCGs, and the increased homogeneity, are qualitatively consistent with models which seek to explain the colors of the most massive galaxies by invoking dry dissipationless mergers, since dissipation tends to reduce the sizes of galaxies, and wet mergers which result in star formation would tend to increase the scatter in luminosity at fixed size and velocity dispersion. Furthermore, BCGs define the same g-r color-magnitude relation as the bulk of the early-type population. If BCGs formed from dry mergers, then BCG progenitors must have been red for their magnitudes, suggesting that they hosted older stellar populations than typical for their luminosities. Our findings have two other consequences. First, the R_e-L relation of the early-type galaxy population as a whole (i.e., normal plus BCG) exhibits some curvature. Some of this curvature must be a consequence of the fact that an increasing fraction of the most luminous galaxies are BCGs. The second consequence is suggested by the fact that, despite following a steeper size-luminosity relation, BCGs tend to define a tight relation between dynamical mass R_e sigma^2/G and luminosity. As consequence, we find that BCGs define a shallower sigma-L relation than the bulk of the early-type galaxy population.Comment: 16 pages, 16 figures, AJ in pres

Tidal Turbine Benchmarking Exercise: Environmental Characterisation and Geometry Specification

Uncertainty in tidal turbine loading contributes significantly to conservatism in turbine design. This uncertainty originates not only from a lack of knowledge of the flow field at a particular site, but also from lack of understanding of the fundamental physics which govern the loading and performance of tidal turbines in unsteady and turbulent flow regimes. In order to reduce this conservatism and the costs associated, the mathematical and engineering models used in turbine design must be improved. To facilitate the development of these models requires scale experimental data for validation. However, few well-documented experimental data sets are available for tidal turbines, especially at scales large enough to achieve Reynolds number independence and comparability to full scale devices.This paper reports on the initial phases of a tidal turbine benchmarking project that will conduct a large laboratory scale experimental campaign on a highly instrumented 1.6m diameter tidal rotor. The turbine will be tested in well defined flow conditions, including unsteadiness created by free surface waves, as well as freestream turbulence, with instrumentation to determine edgewise and flapwise loading distributions along the blades as they rotate through the unsteady flows. As towing tanks by their nature have low levels of freestream turbulence, a carriage-mounted turbulence grid will be utilised to generate sufficient freestream turbulence in a well-defined manner.In this paper the turbine geometry and test conditions are specified, as well as providing details of the rotor’s hydrodynamic design process. Additionally, the results of a flow characterisation of the carriage-mounted turbulence grid via Acoustic Doppler Velocimetry are presented. The turbulence grid produced a mean turbulence intensity of 3:5% across the region in which the turbine will be tested, and a very uniform flow profile of 0:913 times the upstream velocity

Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging

s funded by the Seventh Framework Programme (FP7) for HER Imaging and Molecular Interaction Mapping in Breast Cancer (Imagint EC grant 259881) and the Breast Cancer Campaign. The research was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

Background Patients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases, transmembrane protease serine 2 (TMPRSS2) and FURIN, are needed for viral attachment and invasion into host cells. Methods We examined microarray mRNA expression of ACE2, TMPRSS2 and FURIN in sputum, bronchial brushing and bronchial biopsies of the European U-BIOPRED cohort. Clinical parameters and molecular phenotypes, including asthma severity, sputum inflammatory cells, lung functions, oral corticosteroid (OCS) use, and transcriptomic-associated clusters, were examined in relation to gene expression levels. Results ACE2 levels were significantly increased in sputum of severe asthma compared to mild-moderate asthma. In multivariate analyses, sputum ACE2 levels were positively associated with OCS use and male gender. Sputum FURIN levels were significantly related to neutrophils (%) and the presence of severe asthma. In bronchial brushing samples, TMPRSS2 levels were positively associated with male gender and body mass index, whereas FURIN levels with male gender and blood neutrophils. In bronchial biopsies, TMPRSS2 levels were positively related to blood neutrophils. The neutrophilic molecular phenotype characterised by high inflammasome activation expressed significantly higher FURIN levels in sputum than the eosinophilic Type 2-high or the pauci-granulocytic oxidative phosphorylation phenotypes. Conclusion Levels of ACE2 and FURIN may differ by clinical or molecular phenotypes of asthma. Sputum FURIN expression levels were strongly associated with neutrophilic inflammation and with inflammasome activation. This might indicate the potential for a greater morbidity and mortality outcome from SARS-CoV-2 infection in neutrophilic severe asthma