1,124 research outputs found
A meta-analysis of variables that predict significant intracranial injury in minor head trauma.
BACKGROUND: Previous studies have presented conflicting results regarding the predictive effect of various clinical symptoms, signs, and plain imaging for intracranial pathology in children with minor head injury. AIMS: To perform a meta-analysis of the literature in order to assess the significance of these factors and intracranial haemorrhage (ICH) in the paediatric population. METHODS: The literature was searched using Medline, Embase, Experts, and the grey literature. Reference lists of major guidelines were crosschecked. Control or nested case-control studies of children with head injury who had skull radiography, recording of common symptoms and signs, and head computed tomography (CT) were selected. OUTCOME VARIABLE: CT presence or absence of ICH. RESULTS: Sixteen papers were identified as satisfying criteria for inclusion in the meta-analysis, although not every paper contained data on every correlate. Available evidence gave pooled patient numbers from 1136 to 22 420. Skull fracture gave a relative risk ratio of 6.13 (95% CI 3.35 to 11.2), headache 1.02 (95% CI 0.62 to 1.69), vomiting 0.88 (95% CI 0.67 to 1.15), focal neurology 9.43 (2.89 to 30.8), seizures 2.82 (95% CI 0.89 to 9.00), LOC 2.23 (95% CI 1.20 to 4.16), and Glasgow Coma Scale (GCS) <15 of 5.51 (95% CI 1.59 to 19.0). CONCLUSIONS: There was a statistically significant correlation between intracranial haemorrhage and skull fracture, focal neurology, loss of consciousness, and GCS abnormality. Headache and vomiting were not found to be predictive and there was great variability in the predictive ability of seizures. More information is required about the current predictor variables so that more refined guidelines can be developed. Further research is currently underway by three large study groups
Colloidal templating at a cholesteric - oil interface: Assembly guided by an array of disclination lines
We simulate colloids (radius m) trapped at the interface between
a cholesteric liquid crystal and an immiscible oil, at which the helical order
(pitch p) in the bulk conflicts with the orientation induced at the interface,
stabilizing an ordered array of disclinations. For weak anchoring strength W of
the director field at the colloidal surface, this creates a template, favoring
particle positions eitheron top of or midway between defect lines, depending on
. For small , optical microscopy experiments confirm this
picture, but for larger no templating is seen. This may stem from the
emergence at moderate W of a rugged energy landscape associated with defect
reconnections.Comment: 5 pages, 4 figure
Bulk rheology and microrheology of active fluids
We simulate macroscopic shear experiments in active nematics and compare them
with microrheology simulations where a spherical probe particle is dragged
through an active fluid. In both cases we define an effective viscosity: in the
case of bulk shear simulations this is the ratio between shear stress and shear
rate, whereas in the microrheology case it involves the ratio between the
friction coefficient and the particle size. We show that this effective
viscosity, rather than being solely a property of the active fluid, is affected
by the way chosen to measure it, and strongly depends on details such as the
anchoring conditions at the probe surface and on both the system size and the
size of the probe particle.Comment: 12 pages, 10 figure
Colloids in active fluids: Anomalous micro-rheology and negative drag
We simulate an experiment in which a colloidal probe is pulled through an
active nematic fluid. We find that the drag on the particle is non-Stokesian
(not proportional to its radius). Strikingly, a large enough particle in
contractile fluid (such as an actomyosin gel) can show negative viscous drag in
steady state: the particle moves in the opposite direction to the externally
applied force. We explain this, and the qualitative trends seen in our
simulations, in terms of the disruption of orientational order around the probe
particle and the resulting modifications to the active stress.Comment: 5 pages, 3 figure
Comparative performance of Fibre Reinforced Polymer and Fibre Reinforced Cementitious Mortar Strengthening Systems in Elevated Temperature Service Environments
- …