Gravitational intraction on quantum level and consequences thereof

The notion of gravitational emission as an emission of the same level with electromagnetic emission is based on the proven fact of existence of electrons stationary states in its own gravitational field, characterized by gravitational constantComment: 22 pages, 9 figure

Initial State Fluctuations and Complete Destruction of the Projectile Nucleus in Interactions of Asymmetric Nuclei at High Energies

A study of characteristics of the events of complete destruction of the projectile nucleus in the interactions between asymmetric nuclei for different initial states of the collision, is performed. In the interactions of the sulfur nuclei with heavy emulsion nuclei at energy 200 AGeV, anomalous high number of events the complete destruction of the projectile nuclei, is observed. The high probability of such events depends on the energy of interaction (it is not detected in the interactions of the sulfur nuclei with emulsion nuclei at energy of 3.7 AGeV), on the degree of asymmetry of the interacting nuclei (it is not detected in interactions of the sulfur nuclei with light emulsion nuclei) and on initial state of interaction (it is not detected in peripheral collisions). These events are characterized by high multiplicity of secondary particles and narrow angular distribution at large angles (they form narrow peak in the region of small values of average pseudorapidity)

Математическое моделирование влияния вакцинации на распространение эпидемии COVID-19

The mathematical model based on a system of ordinary differential equations is proposed to describe the effect of the vaccination rate on the spread of the COVID-19 epidemic. The results of numerical modeling are presented for the case when vaccination begins after the beginning of the epidemic. A dimensionless vaccination parameter V was obtained, which allows one to characterize the effect of the vaccination rate on the reduction of the incidence of viral diseases with different virulence levels in a large closed population of people. Introducing this parameter allows the simulation results to be generalized to the populations of different size, different epidemic spread rate, different vaccination rate, and different vaccine efficiency. It has been shown that increasing the parameter V decreases the proportion of the sick population. It follows from our model that the vaccination influence on the spread of a respiratory viral disease such as COVID-19 decreases for a later initiation of vaccination. The simulation results should contribute to the development of optimal vaccination scenarios for the population.Предложена математическая модель на основе системы обыкновенных дифференциальных уравнений для описания влияния темпа вакцинации на распространение эпидемии типа COVID-19. Приведены результаты численного моделирования для случая, когда вакцинация начинается после начала распространения эпидемии. Получен безразмерный параметр вакцинации V, который позволяет количественно характеризовать влияние темпа вакцинации на снижение заболеваемости вирусными заболеваниями с различными уровнями вирулентности в большой замкнутой популяции людей. Введение этого параметра позволяет переносить результаты моделирования на популяции других размеров для разных скоростей распространения эпидемии, разных скоростей вакцинирования и разной эффективности вакцин. Показано, что увеличение параметра вакцинации V при прочих равных условиях приводит к снижению доли заболевшего населения. Показано также, что при постоянном темпе вакцинации ее влияние на распространение респираторного вирусного заболевания типа COVID-19 снижается при более позднем начале вакцинации. Результаты моделирования могут способствовать разработке оптимальных сценариев вакцинации населения

РЕЖИМЫ ЭЛЕКТРОСТАТИЧЕСКОГО ОСАЖДЕНИЯ ФЕМТОЛИТРОВЫХ КАПЕЛЬ РАСТВОРОВ НА ПОДЛОЖКУ-ЭЛЕКТРОД ПРИ ПОНИЖЕННОМ ДАВЛЕНИИ

For reduced pressure 60–300 Torr experimental results and theoretical estimates of electrostatic deposition of femtoliter droplets, containing inside nanoparticles, from the gas stream on substrate-electrode are presented. It is shown that the corona discharge with a stream of droplets is stable in a limited range of currents and voltages. Similarity criterion of the process of electrostatic deposition is obtained. It was found that the use a thin dielectric substrate, covering the electrodes, significantly reduces agglomeration of charged droplets due to Coulomb repulsion.Представлены экспериментальные результаты и теоретические оценки осаждения при пониженном давлении 60–300 торр фемтолитровых капель, содержащих внутри наночастицы, из газового потока на подложку-электрод. Показано, что коронный разряд с потоком капель устойчив в ограниченном диапазоне токов и напряжений. Установлен параметр подобия процесса электростатического осаждения. Обнаружено, что осаждение на диэлектрическую подложку, закрывающую электрод, существенно уменьшает агломерацию капель за счет кулоновского отталкивания

Features of parameters of cellular immune depending on the activity of foci of demyelination in children with multiple sclerosis

MS is a common disease of the central nervous system that leads to disability and reduced quality of life. The debut of disease in 3-5% of patients occurs in childhood and has a less favorable course compared to adults. MS is caused by the activation of autoreactive T cells in the breakdown of peripheral tolerance, which is normally controlled by regulatory T cells (Tregs). It is promising to study expression of CD39 and CD73 in Treg and Th17 populations to assess their suppressive activity. Aim is to evaluate content of major and minor lymphocyte populations and expression of CD39 and CD73 in CD4+ lymphocyte population in children with MS. 111 children with MS were examined, 66 with contrast-negative lesions on MRI (Group 1), 45 with contrast-positive lesions (Group 2). The comparison group consisted of 46 healthy children (Group 3). Content of T, B, NK lymphocytes, Treg (CD4+CD25highCD127low), Thact (CD4+CD25highCD127high), Th17 cells (CD3+CD4+CD161+); expression of CD39 and CD73 in Treg, Th17 and Thact was performed by flow cytometry. An increase in content of T helpers, a decrease in NK cells in patients in group 2 was revealed. An increase in number of Thact and Th17 lymphocytes was obtained in patients of both groups with MS. Number of Tregs in group 1 was significantly higher than in group 3. Ratio of cells expressing CD39 and CD73 in MS patients depended on lymphocyte population as well as in the group 3. The highest content of CD39+ cells was observed in Treg population, and the lowest in Thact population. For CD73 expression, on the contrary, the highest expression of CD73 was observed in Thact cells, the lowest in Treg. When comparing groups of patients, it was found that in patients of group 1, number of cells expressing CD39 ectonucleotidase was significantly increased, and number of supTh17 was comparable with group 3. In both groups of MS patients, an increase in CD73 counts in Treg, Thact and Th17 was observed. Thus, informative populations of lymphocytes (CD4+ cells, Treg, CD39+Treg, supTh17) have been identified, which can be used to monitor condition of children with multiple sclerosis