100 research outputs found
Single mothering as experienced by Burundian refugees in Australia: a qualitative inquiry
An Intersectional Exploration: Experiences of Stroke Prevention in Middle-Aged and Older Arab Muslim Immigrant Women in Canada
Cross-cultural comparison of fertility specific quality of life in German, Hungarian and Jordanian couples attending a fertility center
“A man’s gonna do what a man wants to do”: African American and Hispanic women’s perceptions about heterosexual relationships: a qualitative study
The Social Determinants of Refugee Mental Health in the Post-Migration Context: A Critical Review
Effects of dimethyl sulfoxide and other dipolar aprotic solvents on rat hepatic adenylate cyclase. Potentiating effects on glucagon and guanylylimidodiphosphate stimulation
In situ detection of cyclic AMP-phosphodiesterase activity in the heart of Lewis and Sprague-Dawley rats: the effect of restraint stress or amphetamine application
Cyclic AMP plays an important role in heart
functions under normal as well as pathological
conditions. Since phosphodiesterase (PDE), responsible
for the hydrolysis of cAMP, is equally important as
synthesizing adenylyl cyclase, we decided to determine
its activity by cytochemical procedure after exposure of
rats to restraint stress or an acute dose of amphetamine.
Sprague-Dawley (S-D) and Lewis (LE) rats, the latter
known to have a deficient hypothalamo-pituitary-adrenal
axis activity, were used in order to disclose the possible
significance of rat strain on PDE activity. Animals were
divided into 3 groups: controls, rats treated with an acute
dose of amphetamine (8 mg/kg, i.p., for 60 min) and rats
under restraint stress for 60 min. Control hearts of both
strains revealed PDE activity on sarcolemma of
cardiomyocytes and plasmalemma of endothelial cells of
microvessels. In LE rats we observed an additional
enzyme reaction in junctional sarcoplasmic reticulum. In
addition, cardiomyocytes of LE rats revealed a higher
PDE activity when compared to S-D rats. Restraint
stress decreased PDE activity in cardiomyocytes of LE
rats while amphetamine markedly inhibited enzyme
activity in cardiomyocytes of S-D rats. Endothelial PDE
was more resistant to stress. Our results indicate
differences in PDE localization and variations in
sensitivity of myocardial cAMP-PDE of LE and S-D rat
strains to restraint stress and amphetamine applicatio
Social networks and health-promoting behaviors among North Korean refugees in South Korea
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