68 research outputs found
In vitro Anticancer Screening of 24 Locally Used Nigerian Medicinal Plants
Get PDFBackground: Plants that are used as traditional medicine represent a relevant pool for selecting plant candidates that may have anticancer properties. In this study, the ethnomedicinal approach was used to select several medicinal plants native to Nigeria, on the basis of their local or traditional uses. The collected plants were then evaluated for cytoxicity. Methods: The antitumor activity of methanolic extracts obtained from 24 of the selected plants, were evaluated in vitro on five human cancer cell lines. Results: Results obtained from the plants screened indicate that 18 plant extracts of folk medicine exhibited promising cytotoxic activity against human carcinoma cell lines. Erythrophleum suaveolens (Guill. & Perr.) Brenan was found to demonstrate potent anti-cancer activity in this study exhibiting IC50 = 0.2-1.3 g/ml. Conclusions: Based on the significantly potent activity of some plants extracts reported here, further studies aimed at mechanism elucidation and bio-guided isolation of active anticancer compounds is currently underway.Chemistry and Chemical Biolog
BioPerspectives - From basic research to industrial production
No full textGrabley S, Pühler A. BioPerspectives - From basic research to industrial production. JOURNAL OF BIOTECHNOLOGY. 2006;124(1):1-3
SECONDARY METABOLITES BY CHEMICAL-SCREENING .2. AMYCIN-A AND AMYCIN-B, 2, NOVEL NIPHIMYCIN ANALOGS ISOLATED FROM A HIGH PRODUCER STRAIN OF ELAIOPHYLIN AND NIGERICIN
No full textAufbau und Nutzung eines Naturstoff-Pools zur Auffindung neuer Leitstrukturen. Teilprojekt 1: Mikrobielle Naturstoffe Abschlussbericht
No full textSIGLEAvailable from TIB Hannover: F00B1143 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman
Miniaturization of an Enzyme Assay (β-Galactosidase) in the 384- and 1536-Well Plate Format
No full textSynthetic Application of Acylnitroso Diels-Alder Derived Aminocyclopentenols: Total Synthesis of (+)-Streptazolin
No full textFatty acyl benzamido antibacterials based on inhibition of DnaK-catalyzed protein folding
No full textLIBRARIAN Phase II. Teilprojekt HKI: Reflektometrische Interferenzspektroskopie als Detektionsmethode fuer das Screening von Naturstoffen Abschlussbericht
No full textSIGLEAvailable from TIB Hannover: F02B631 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung und Forschung, Berlin (Germany)DEGerman
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