The Genetic Basis of Mutation Rate Variation in Yeast.

Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis of these differences. Here, we leveraged the power of the yeast Saccharomyces cerevisiae as a model system to uncover natural genetic variants that underlie variation in mutation rate. We developed a high-throughput fluctuation assay and used it to quantify mutation rates in seven natural yeast isolates and in 1040 segregant progeny from a cross between BY, a laboratory strain, and RM, a wine strain. We observed that mutation rate varies among yeast strains and is heritable (H 2 = 0.49). We performed linkage mapping in the segregants and identified four quantitative trait loci underlying mutation rate variation in the cross. We fine-mapped two quantitative trait loci to the underlying causal genes, RAD5 and MKT1, that contribute to mutation rate variation. These genes also underlie sensitivity to the DNA-damaging agents 4NQO and MMS, suggesting a connection between spontaneous mutation rate and mutagen sensitivity

Generalizations of Weighted Trapezoidal Inequality for Monotonic Mappings and Its Applications

In this paper, we establish some generalizations of weighted trapezoid inequality for monotonic mappings, and give several applications for r − moment, the expectation of a continuous random variable and the Beta mapping

Bimetric varying speed of light theories and primordial fluctuations

We exhibit a varying speed of light (VSL) theory that implements the recently proposed decaying speed of sound mechanism for generating density fluctuations. We avail ourselves of bimetric VSL theories, where the speed of gravity differs from that of light. We first show that a Dirac-Born-Infeld (DBI) type of $K$-essence has the necessary speed of sound profile to produce (near) scale-invariant fluctuations. We then examine the map between bimetric and $K$-essence models: typically the bi-scalar connecting the two metrics is a $K$-essence field in one of them. Remarkably, the DBI model is found to perturbatively represent the minimal bimetric model, where the bi-scalar is Klein-Gordon in the matter frame. But the full non-perturbative bimetric structure is even simpler: the bi-scalar dynamics should be simply driven by a cosmological constant in the matter frame, balanced by an opposite cosmological constant in the gravity frame. Thus the problem of structure formation receives an elegant and universal solution within bimetric VSL theories, which are known to also solve the flatness and entropy problems and evade a plethora of causality concerns

Equilibrium vortex formation in ultrarapidly rotating two-component Bose-Einstein condensates

Equilibrium vortex formation in rotating binary Bose gases with a rotating frequency higher than the harmonic trapping frequency is investigated theoretically. We consider the system being evaporatively cooled to form condensates and a combined numerical scheme is applied to ensure the binary system being in an authentic equilibrium state. To keep the system stable against the large centrifugal force of ultrafast rotation, a quartic trapping potential is added to the existing harmonic part. Using the Thomas-Fermi approximation, a critical rotating frequency \Omega_c is derived, which characterizes the structure with or without a central density hole. Vortex structures are studied in detail with rotation frequency both above and below ?\Omega_c and with respect to the miscible, symmetrically separated, and asymmetrically separated phases in their nonrotating ground-state counterparts.Comment: 7 pages, 7 figure

GRB Afterglows from Anisotropic Jets

Some progenitor models of gamma-ray bursts (GRBs) (e.g., collapsars) may produce anisotropic jets in which the energy per unit solid angle is a power-law function of the angle ($\propto\theta^{-k}$). We calculate light curves and spectra for GRB afterglows when such jets expand either in the interstellar medium or in the wind medium. In particular, we take into account two kinds of wind: one ($n\propto r^{-3/2}$) possibly from a typical red supergiant star and another ($n\propto r^{-2}$) possibly from a Wolf-Rayet star. We find that in each type of medium, one break appears in the late-time afterglow light curve for small $k$ but becomes weaker and smoother as $k$ increases. When $k\ge 2$, the break seems to disappear but the afterglow decays rapidly. Thus, one expects that the emission from expanding, highly anisotropic jets provides a plausible explanation for some rapidly fading afteglows whose light curves have no break. We also present good fits to the optical afterglow light curve of GRB 991208. Finally, we argue that this burst might arise from a highly anisotropic jet expanding in the wind ($n\propto r^{-3/2}$) from a red supergiant to interpret the observed radio-to-optical-band afterglow data (spectrum and light curve).Comment: 12 pages + 10 figures, accepted by Ap

Dynamical Equilibration Across a Quenched Phase Transition in a Trapped Quantum Gas

The formation of an equilibrium quantum state from an uncorrelated thermal one through the dynamical crossing of a phase transition is a central question of non-equilibrium many-body physics. During such crossing, the system breaks its symmetry by establishing numerous uncorrelated regions separated by spontaneously-generated defects, whose emergence obeys a universal scaling law with the quench duration. Much less is known about the ensuing re-equilibrating or "coarse-graining" stage, which is governed by the evolution and interactions of such defects under system-specific and external constraints. In this work we perform a detailed numerical characterization of the entire non-equilibrium process, addressing subtle issues in condensate growth dynamics and demonstrating the quench-induced decoupling of number and coherence growth during the re-equilibration process. Our unique visualizations not only reproduce experimental measurements in the relevant regimes, but also provide valuable information in currently experimentally-inaccessible regimes.Comment: Supplementary Movie Previes: SM-Movie-1: https://youtu.be/3q7-CvuBylg SM-Movie-2: https://youtu.be/-Gymaiv9rC0 SM-Movie-3: https://youtu.be/w-O2SPiw3nE SM-Movie-4: https://youtu.be/P4xGyr4dwK