Three case reports of familial erythrophagocytic lymphohistiocytosis

Childhood histiocytosis constitutes a diverse group of disorders that have presented great difficulties for pediatricians in diagnosis and treatment. In the bone marrow, there is proliferation of histiocytes and cells of the mononuclear phagocytic systems. Class II Histiocytosis; the predominant cells are the normal cells of the monocytic-macrophage systems. There is no atypic cellularity. Commonly lymphohistiocytic infiltration is observed. Familial hemophagocytic lymphohistiocytosis, also known as erytrophagocytic lymphohistiocytosis (FEL) is a rare inherited disorder, whose genetic basis is unknown, characterised by multiorgan infiltration by lymphocytes and histiocytes. We would like to present three cases of FEL in which, two of them are siblings of the same family and the third case is the cousin of these two siblings

Hypothermia trend after administration of dipyrone [Dipiron sonrasi hipotermiye egilim]

Hypothermia may occur in winter or winter sports, immersion, and wet wind chill. Besides, hypothermia may occur in cardiac disease, diabetes mellitus, hyperinsulinemia, sepsis, and substance abuse. We hereby present two cases of acute leukemia in whom hypothermia was seen after administering dipyrone during high fever. The first case, is a 13 year old girl, with acute lymphoblastic leukemia (ALL-L3). The second case is a 14 year old boy, who was previously diagnosed as myelodysplastic syndrome, than turned to acute myeloblastic leukemia (AML-M7). In both cases, febrile neutropenia was observed after induction of chemotherapy, and their body temperature was 38.4°C and 39% (axillar) respectively, and after administering dipyrone, their body temperature dropped to 35.2°C and 35% respectively