Design of dimensional model for clinical data storage and analysis

Current research in the field of Life and Medical Sciences is generating chunk of data on daily basis. It has thus become a necessity to find solutions for efficient storage of this data, trying to correlate and extract knowledge from it. Clinical data generated in Hospitals, Clinics & Diagnostics centers is falling under a similar paradigm. Patient’s records in various hospitals are increasing at an exponential rate, thus adding to the problem of data management and storage. Major problem being faced corresponding to storage, is the varied dimensionality of the data, ranging from images to numerical form. Therefore there is a need for development of efficient data model which can handle this multi-dimensionality data issue and store the data with historical aspect. For the stated problem lying in façade of clinical informatics we propose a clinical dimensional model design which can be used for development of a clinical data mart. The model has been designed keeping in consideration temporal storage of patient's data with respect to all possible clinical parameters which can include both textual and image based data. Availability of said data for each patient can be then used for application of data mining techniques for finding the correlation of all the parameters at the level of individual and population

The effects of transients on photospheric and chromospheric power distributions

We have observed a quiet Sun region with the Swedish 1-meter Solar Telescope (SST) equipped with CRISP Imaging SpectroPolarimeter. High-resolution, high-cadence, H$\alpha$ line scanning images were taken to observe different layers of the solar atmosphere from the photosphere to upper chromosphere. We study the distribution of power in different period-bands at different heights. Power maps of the upper photosphere and the lower chromosphere show suppressed power surrounding the magnetic-network elements, known as "magnetic shadows". These also show enhanced power close to the photosphere, traditionally referred to as "power halos". The interaction between acoustic waves and inclined magnetic fields is generally believed to be responsible for these two effects. In this study we explore if small-scale transients can influence the distribution of power at different heights. We show that the presence of transients, like mottles, Rapid Blueshifted Excursions (RBEs) and Rapid Redshifted Excursions (RREs), can strongly influence the power-maps. The short and finite lifetime of these events strongly affects all powermaps, potentially influencing the observed power distribution. We show that Doppler-shifted transients like RBEs and RREs that occur ubiquitously, can have a dominant effect on the formation of the power halos in the quiet Sun. For magnetic shadows, transients like mottles do not seem to have a significant effect in the power suppression around 3 minutes and wave interaction may play a key role here. Our high cadence observations reveal that flows, waves and shocks manifest in presence of magnetic fields to form a non-linear magnetohydrodynamic system.Comment: 11 pages, 11 Figures, 4 movies (will be available online in ApJ). ApJ (accepted

An improved block matching algorithm for motion estimation in video sequences and application in robotics

Block Matching is one of the most efficient techniques for motion estimation for video sequences. Metaheuristic algorithms have been used effectively for motion estimation. In this paper, we propose two hybrid algorithms: Artificial Bee Colony with Differential Evolution and Harmony Search with Differential Evolution based motion estimation algorithms. Extensive experiments are conducted using four standard video sequences. The video sequences utilized for experimentation have all essential features such as different formats, resolutions and number of frames which are generally required in input video sequences. We compare the performance of the proposed algorithms with other algorithms considering various parameters such as Structural Similarity, Peak Signal to Noise Ratio, Average Number of Search Points etc. The comparative results demonstrate that the proposed algorithms outperformed other algorithms

Bianchi type-II cosmological model: some remarks

Within the framework of Bianchi type-II (BII) cosmological model the behavior of matter distribution has been considered. It is shown that the non-zero off-diagonal component of Einstein tensor implies some severe restriction on the choice of matter distribution. In particular for a locally rotationally symmetric Bianchi type-II (LRS BII) space-time it is proved that the matter distribution should be strictly isotropic if the corresponding matter field possesses only non-zero diagonal components of the energy-momentum tensor.Comment: 3 page

ELECTIVE EXPERIENCES OF FOREIGN MEDICAL STUDENTS AT THE TEACHING HOSPITAL OF TRIBHUVAN UNIVERSITY INSTITUTE OF MEDICINE, NEPAL

This paper has attempted to document and analyze the trend and experiences of foreign medical students enrolled in the elective programme organized by the Medical Education Department (MED) at the Teaching Hospital of the Tribhuvan University (TUTH), Institute of Medicine in Kathmandu. Elective documents have been analyzed for the period between 1997-2000 and a written questionnaire survey has been administered to a total of 73 foreign medical students who completed elective in the year 2000. Over a period of four years a total of 268 students had undergone elective posting in various departments of TUTH. More than half of the students (55%) came from European universities. More than 60% of respondents (n=73) considered the opportunity to see variety of patients as the main strength of the elective programme. Overwhelming majority of respondents (95%) rated the learning experience as good or excellent. The most favoured department was the Internal Medicine. The study demonstrates the unique value of elective in enriching student learning in medical education. The traditional belief that all students should have a uniform curriculum throughout their training has been largely challenged. 1 The insights gained could perhaps, inspire medical schools to seriously think about introducing elective provision as an essential component of their undergraduate curricula. 1. Medical Education Department, TU Institute of Medicine. Address for correspondence : Dr. D. S. Pant, MD, MHPED, Assistant Director & Elective Programme Coordinator, Medical Education Department, TU Institute of Medicine, P.O. Box: 1524, Kathmandu, Nepal. Email: [email protected], Home Page: www.nchped.org.np Key Words: Elective terms, overseas elective, elective experience in developing countries, core and elective options, undergraduate medical elective

Identification of single nucleotide polymorphisms in bovine CARD15 and their associations with health and production traits in Canadian Holsteins

<p>Abstract</p> <p>Background</p> <p>Toll-like receptor-2 (TLR2) and Caspase Recruitment Domain 15 (CARD15) are important pattern recognition receptors that play a role in the initiation of the inflammatory and subsequent immune response. They have been previously identified as susceptibility loci for inflammatory bowel diseases in humans and are, therefore, suitable candidate genes for inflammatory disease resistance in cattle. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the bovine <it>TLR2 </it>and <it>CARD15 </it>and evaluate the association of these SNPs with health and production traits in a population of Canadian Holstein bulls.</p> <p>Results</p> <p>A selective DNA pool was constructed based on the estimated breeding values (EBVs) for SCS. Gene segments were amplified from this pool in PCR reactions and the amplicons sequenced to reveal polymorphisms. A total of four SNPs, including one in intron 10 (c.2886-14A>G) and three in the exon 12 (c.3020A>T, c.4500A>C and c.4950C>T) were identified in <it>CARD15</it>; none were identified in <it>TLR2</it>. Canadian Holstein bulls (n = 338) were genotyped and haplotypes were reconstructed. Two SNPs, c.3020A>T and c.4500A>C, were associated with EBVs for health and production traits. The SNP, c.3020A>T, for example, was associated with SCS EBVs (p = 0.0097) with an allele substitution effect of 0.07 score. When compared to the most frequent haplotype Hap12(AC), Hap22(TC) was associated with increased milk (p < 0.0001) and protein (p = 0.0007) yield EBVs, and hap21(TA) was significantly associated with increased SCS EBV(p = 0.0120). All significant comparison-wise associations retained significance at 8% experimental-wise level by permutation test.</p> <p>Conclusion</p> <p>This study indicates that SNP c.3020A>T might play a role in the host response against mastitis and further detailed studies are needed to understand its functional mechanisms.</p

Charge and Spin Response of the Spin--Polarized Electron Gas

The charge and spin response of a spin--polarized electron gas is investigated including terms beyond the random phase approximation. We evaluate the charge response, the longitudinal and transverse spin response, and the mixed spin--charge response self--consistently in terms of the susceptibility functions of a non--interacting system. Exchange--correlation effects between electrons of spin $\sigma$ and $\sigma^{'}$ are included following Kukkonen and Overhauser, by using spin--polarization dependent generalized Hubbard local field factors ${G_\sigma}^{\pm}$ and ${G_{\bar\sigma}}^{\pm}$. The general condition for charge--density and spin--density--wave excitations of the system is discussed.Comment: 4 pages, latex, no figure