Population level survival of patients with chronic myelocytic leukemia in Germany compared to the US in the early 21st century

INTRODUCTION: The advent of tyrosine kinase inhibitors has produced 5-year survival of 90 + % for chronic myelocytic leukemia (CML) patients in clinical trials. However, population level survival has been lower, especially in older patients. Here, we examine survival of patients with CML in Germany and compare it to survival of patients in the United States (US). METHODS: Data were extracted from the Surveillance, Epidemiology, and End Results database in the US and 11 cancer registries in Germany. Patients 15–69 years old diagnosed with CML were included in the analysis. Period analysis for 2002–2006 was used to provide the most up-to-date possible estimates of five-year relative survival. RESULTS: Five-year relative survival was 68.7% overall in Germany and 72.7% in the US. Survival was higher in the US for all age groups except for ages 15–39 years, but the difference was only statistically significant for ages 50–59 years (at 67.5% vs 77.7% in Germany and the US, respectively). Survival decreased with age, ranging from 83.1% and 81.9%, respectively, in Germany and the US for patients 15–39 years old to 54.2% and 54.5%, respectively, in patients 65–69 years old. Survival increased between 2002 and 2006 by 12.0% points in Germany and 17.1% points in the US. CONCLUSIONS: Five-year survival estimates were higher in the US than in Germany overall, but the difference was only significant for ages 50–59 years. Survival did not equal that seen in clinical trials for either country, but strong improvement in survival was seen between 2002 and 2006

Perceived Out-Group (Dis)Continuity and Attribution of Responsibility for the Lebanese Civil War Mediate Effects of National and Religious Subgroup Identification on Intergroup Attitudes

Successful reconciliation between groups following a violent conflict requires psychological change. We test a model predicting intergroup attitudes towards Muslims in Lebanon among Maronite (Christian) Lebanese youths. Identification with both their religious subgroup and with the superordinate national group predicted attitudes towards Muslims, in opposite directions. These effects of levels of identification on intergroup attitudes were mediated by attributions of responsibility for the war (Muslim responsibility) and perception that the current generation of out-group members is different from the war generation (perceived out-group discontinuity). Identification with Lebanon fosters positive attitudes towards Muslims by lowering Muslim responsibility for the war, and by increasing perceptions of foreign responsibility and perceived out-group discontinuity. In contrast, increased identification with their own religious subgroup undermines attitude change by increasing Muslim responsibility for the war and lessening perception of out-group discontinuity. Representations of the past have implications for attitudes towards former enemies and reconciliation in the present.SCOPUS: ar.jinfo:eu-repo/semantics/publishe