Josephson Effect in Pb/I/NbSe2 Scanning Tunneling Microscope Junctions

We have developed a method for the reproducible fabrication of superconducting scanning tunneling microscope (STM) tips. We use these tips to form superconductor/insulator/superconductor tunnel junctions with the STM tip as one of the electrodes. We show that such junctions exhibit fluctuation dominated Josephson effects, and describe how the Josephson product IcRn can be inferred from the junctions' tunneling characteristics in this regime. This is first demonstrated for tunneling into Pb films, and then applied in studies of single crystals of NbSe2. We find that in NbSe2, IcRn is lower than expected, which could be attributed to the interplay between superconductivity and the coexisting charge density wave in this material.Comment: 3 pages, 2 figures. Presented at the New3SC-4 meeting, San Diego, Jan. 16-21 200

Fusarium mycotoxin-contaminated wheat containing deoxynivalenol alters the gene expression in the liver and the jejunum of broilers

The effects of mycotoxins in the production of animal feed were investigated using broiler chickens. For the feeding trial, naturally Fusarium mycotoxin-contaminated wheat was used, which mainly contained deoxynivalenol (DON). The main effects of DON are reduction of the feed intake and reduced weight gain of broilers. At the molecular level, DON binds to the 60 S ribosomal subunit and subsequently inhibits protein synthesis at the translational level. However, little is known about other effects of DON, for example, at the transcriptional level. Therefore, a microarray analysis was performed, which allows the investigation of thousands of transcripts in one experiment. In the experiment, 20 broilers were separated into four groups of five broilers each at day 1 after hatching. The diets consisted of a control diet and three diets with calculated, moderate concentrations of 1.0, 2.5 and 5.0 mg DON/kg feed, which was attained by exchanging uncontaminated wheat with naturally mycotoxin-contaminated wheat up to the intended DON concentration. The broilers were held at standard conditions for 23 days. Three microarrays were used per group to determine the significant alterations of the gene expression in the liver (P < 0.05), and qPCR was performed on the liver and the jejunum to verify the results. No significant difference in BW, feed intake or feed conversion rate was observed. The nutrient uptake into the hepatic and jejunal cells seemed to be influenced by genes: SLC2A5 (fc: −1.54, DON2.5), which facilitates glucose and fructose transport and SLC7A10 (fc: +1.49, DON5), a transporter of d-serine and other neutral amino acids. In the jejunum, the palmitate transport might be altered by SLC27A4 (fc: −1.87, DON5) and monocarboxylates uptake by SLC16A1 (fc: −1.47, DON5). The alterations of the SLC gene expression may explain the reduced weight gain of broilers chronically exposed to DON-contaminated wheat. The decreased expressions of EIF2AK3 (fc: −1.29, DON2.5/5) and DNAJC3 (fc: −1.44, DON2.5) seem to be related to the translation inhibition. The binding of DON to the 60 S ribosomal subunit and the subsequent translation inhibition might be counterbalanced by the downregulation of EIF2AK3 and DNAJC3. The genes PARP1, MPG, EME1, XPAC, RIF1 and CHAF1B are mainly related to single-strand DNA modifications and showed an increased expression in the group with 5 mg DON/kg feed. The results indicate that significantly altered gene expression was already occurring at 2.5 mg DON/kg fee

Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi-institutional retrospective study

Background: Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. Methods: This multicenter retrospective analysis reviewed patients who underwent electrochemotherapy from 2007 to 2014 for superficial advanced angiosarcomas. Bleomycin was administered intravenously and delivered within tumors by means of percutaneously applied electric pulses, according to the European Standard Operating Procedures for Electrochemotherapy. Tumor assessment was performed using RECIST (version 1.1). Toxicity (CTCAE, v4.0) and local progression-free survival (LPFS) were also evaluated. Results: Nineteen patients (13 with locally advanced and 6 with metastatic angiosarcomas) were treated. Tumor sites were: scalp (n¼5), breast(n¼8), other skin sites (n¼3), and soft tissue (n¼3). Target lesions (n¼54) ranged in size from 1.5 to 2.5 cm (median, 2 cm). Treatment was well tolerated. After 2 months, an objective response was observed in 12/19 (63%) patients, complete in 8 (42%). One-year LPFS within treatment field was 68%. Local symptom improvement included palliation of bleeding (5/19 patients) and pain relief (6/19 patients). Conclusions: Electrochemotherapy may represent a new locoregional treatment for selected patients with superficial angiosarcomas

Cosmological Perturbations Generated in the Colliding Bubble Braneworld Universe

We compute the cosmological perturbations generated in the colliding bubble braneworld universe in which bubbles filled with five-dimensional anti-de Sitter space (AdS5)expanding within a five dimensional de Sitter space (dS5) or Minkowski space (M5) collide to form a (3+1) dimensional local brane on which the cosmology is virtually identical to that of the Randall-Sundrum model. The perturbation calculation presented here is valid to linear order but treats the fluctuations of the expanding bubbles as (3+1) dimensional fields localized on the bubble wall. We find that for bubbles expanding in dS5 the dominant contribution to the power spectrum is `red' but very small except in certain cases where the fifth dimension is not large or the bubbles have expanded to far beyond the dS5 apparent horizon length. This paper supersedes a previous version titled "Exactly Scale-Invariant Cosmological Perturbations From a Colliding Bubble Braneworld Universe" in which we erroneously claimed that a scale-invariant spectrum results for the case of bubbles expanding in M5. This present paper corrects the errors of the previous version and extends the analysis to the more interesting and general case of bubbles expanding in dS5.Comment: 29 pages Latex with eps figures. Major errors in the original version of the paper corrected and analysis extended to bubbles expanding in dS

Size-dependent Surface States on Strained Cobalt Nanoislands on Cu(111)

Low-temperature scanning tunneling spectroscopy over Co nanoislands on Cu(111) showed that the surface states of the islands vary with their size. Occupied states exhibit a sizeable downward energy shift as the island size decreases. The position of the occupied states also significantly changes across the islands. Atomic-scale simulations and ab inito calculations demonstrate that the driving force for the observed shift is related to size-dependent mesoscopic relaxations in the nanoislands.Comment: 4 pages, 4 figure

Holographic analysis of diffraction structure factors

We combine the theory of inside-source/inside-detector x-ray fluorescence holography and Kossel lines/x ray standing waves in kinematic approximation to directly obtain the phases of the diffraction structure factors. The influence of Kossel lines and standing waves on holography is also discussed. We obtain partial phase determination from experimental data obtaining the sign of the real part of the structure factor for several reciprocal lattice vectors of a vanadium crystal.Comment: 4 pages, 3 figures, submitte

Anisotropic Electronic Structure of the Kondo Semiconductor CeFe2Al10 Studied by Optical Conductivity

We report temperature-dependent polarized optical conductivity [$\sigma(\omega)$] spectra of CeFe$_2$Al$_{10}$, which is a reference material for CeRu$_2$Al$_{10}$ and CeOs$_2$Al$_{10}$ with an anomalous magnetic transition at 28 K. The $\sigma(\omega)$ spectrum along the b-axis differs greatly from that in the $ac$-plane, indicating that this material has an anisotropic electronic structure. At low temperatures, in all axes, a shoulder structure due to the optical transition across the hybridization gap between the conduction band and the localized $4f$ states, namely $c$-$f$ hybridization, appears at 55 meV. However, the gap opening temperature and the temperature of appearance of the quasiparticle Drude weight are strongly anisotropic indicating the anisotropic Kondo temperature. The strong anisotropic nature in both electronic structure and Kondo temperature is considered to be relevant the anomalous magnetic phase transition in CeRu$_2$Al$_{10}$ and CeOs$_2$Al$_{10}$.Comment: 5 pages, 4 figure

Curvature of the Universe and Observed Gravitational Lens Image Separations Versus Redshift

In a flat, k=0 cosmology with galaxies that approximate singular isothermal spheres, gravitational lens image separations should be uncorrelated with source redshift. But in an open k=-1 cosmology such gravitational lens image separations become smaller with increasing source redshift. The observed separations do become smaller with increasing source redshift but the effect is even stronger than that expected in an Omega=0 cosmology. The observations are thus not compatible with the "standard" gravitational lensing statistics model in a flat universe. We try various open and flat cosmologies, galaxy mass profiles, galaxy merging and evolution models, and lensing aided by clusters to explain the correlation. We find the data is not compatible with any of these possibilities within the 95% confidence limit, leaving us with a puzzle. If we regard the observed result as a statistical fluke, it is worth noting that we are about twice as likely to observe it in an open universe (with 0<Omega<0.4) as we are to observe it in a flat one. Finally, the existence of an observed multiple image lens system with a source at z=4.5 places a lower limit on the deceleration parameter: q_0 > -2.0.Comment: 21 pages, 4 figures, AASTeX