Correlation of pre-operative cancer imaging techniques with post-operative gross and microscopic pathology images

In this paper, different algorithms for volume reconstruction from tomographic cross-sectional pathology slices are described and tested. A tissue-mimicking phantom made with a mixture of agar and aluminium oxide was sliced at different thickness as per pathological standard guidelines. Phantom model was also virtually sliced and reconstructed in software. Results showed that shape-based spline interpolation method was the most precise, but generated a volume underestimation of 0.5%

In Situ Liquid Cell Electron Microscopy of the Solution Growth of Au–Pd Core–Shell Nanostructures

Using in situ liquid cell electron microscopy we investigate Pd growth in dilute aqueous Pd salt solutions containing Au nanoparticle seeds. Au–Pd core–shell nanostructures are formed via deposition of Pd⁰, generated by the reduction of chloropalladate complexes by radicals, such as hydrated electrons (e_aq^–) induced by the electron beam in the solution. The size and shape of the Au seeds determine the morphology of the Pd shells, via preferential Pd incorporation in low-coordination sites and avoidance of extended facets. Analysis of the Pd incorporation on Au particles at different distances from a focused electron beam provides a quantitative picture of the growth process and shows that the growth is limited by the diffusion of e_aq^– in the solution