9 research outputs found
Histone Deacetylase Inhibitor Tributyrin and Vitamin A in Cancer
Bioactive food compounds like vitamin A and the butyrateâs prodrug tributyrin
have preventive activities against different types of cancer, and their use in
association could represent a promising strategy for cancer treatment and che-
moprevention. Both compounds can induce cell differentiation and apoptosis of
neoplastic and preneoplastic cells by means of modulation of gene transcription,
yet they act through different but interconnected mechanisms. Vitamin A acts
through nuclear receptors that are tightly regulated by histone modifications such
as acetylation and DNA methylation. Tributyrin modulates transcription of genes
by HDACs inhibition and histone hyperacetylation. This chapter describes how
epigenetics mediates the antineoplastic and chemopreventive activity of vitamin
A, tributyrin, and their derivatives and how their combination can be used to help
overcome current limitations in cancer treatment and prevention. We also show
how the mechanisms of action of vitamin A and tributyrin have aided in the
development of synthetic and bioengineered compounds like synthetic retinoids
and structured lipids, respectively.UCR::VicerrectorĂa de Docencia::Salud::Facultad de Medicina::Escuela de Medicin