Comparative cephalometric study of Class II division 1 malocclusion between Lithuanian and Jordanian females

SUMMARY The Class II malocclusions have a strong hereditary component as etiologic factor, both in families and in ethnic and racial groups. The purpose of this study to compare skeletal and dentoalveolar morphology in Class II division I malocclusion of Lithuanian and Jordanian females. The sample consisted of 60 standardized lateral cephalograms (30 Jordanian -30 Lithuanian). The mean age of the subjects was 14.8±1.11 years. Criteria for cephalometric comparison were 5 linear and 10 angular cephalometric variables. Repeating landmark identification tested reproducibility of the measurements. Unpaired t-test was performed to assess the difference of malocclusion between both groups. Results considered to be statistically significant when p£0.05. Results showed that Lithuanian females had reduced vertical skeletal relationship in their Class II division 1 malocclusion, while Jordanian females characterized by increased vertical relationship. Dentoalveolar measurements showed a significant proclination of the mandibular incisors in Jordanian females compared with Lithuanians

Echocardiographic Parameters of Severity in Isolated Neonatal Patent Ductus Arteriosus

Background: A hemodynamically-significant patent ductus arteriosus (hsPDA) compromises the early neonatal transition. There is no general agreement on echocardiographic indicators of hsPDA that can predict clinical decompensation. Aim of the Work: We aimed to assess echocardiographic parameters that are associated with the isolated PDA effects on hemodynamics, which could help in subsequent management decision making. Materials and Methods: We conducted a prospective observational analytical study on 50 neonates with isolated PDA and 20 controls. They underwent clinical and echocardiographic assessment at 48 hours of age, after another 48-72 hours and prior to discharge. Results: No correlation was found between PDA diameter and weight (p=0.72), length (p=0.11), Body surface area (BSA) (p=0.33), gestational age (p=0.13). A strong association of PDA-related hemodynamic instability was found with pulmonary hypertension (p=<0.01 & 0.05 for initial and latter studies). Left atrium diameter (LA) Z-score was higher among cases, correlated with PDA size in the 3 echocardiographic studies (p=0.001, 0.001 and 0.007 respectively), and correlated with hemodynamic instability in the initial study (p=0.03). Diameter of descending aorta at level of diaphragm and pulmonary flow/systemic flow ratio (Qp:Qs) correlated with PDA diameter in the latter 2 studies (p=0.001). Main pulmonary artery and left pulmonary artery (LPA) Z-scores were correlated with PDA size at the initial and follow-up studies as expected (p=0.001, 0.047 & 0.047; and p=0.004, 0.018 & 0.032, respectively). LPA Z-score correlated with hemodynamic instability at the follow-up study (p=0.005), which was not sustained at the subsequent study. Conclusion: Pulmonary hypertension, larger LA Z-score and LPA Z-scores are important early (at 48 hours) associations of a hsPDA and hemodynamic instability

Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors

<p>Abstract</p> <p>Background</p> <p>Activating mutations in Kit receptor tyrosine kinase or the related platelet-derived growth factor receptor (PDGFR) play an important role in the pathogenesis of gastrointestinal stromal tumors (GIST).</p> <p>Methods</p> <p>This study investigated the activity of motesanib, an inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3; PDGFR; and Kit, against primary activating Kit mutants and mutants associated with secondary resistance to imatinib. Single- and double-mutant isoforms of Kit were evaluated for their sensitivity to motesanib or imatinib in autophosphorylation assays and in Ba/F3 cell proliferation assays.</p> <p>Results</p> <p>Motesanib inhibited Kit autophosphorylation in CHO cell lines expressing primary activating mutations in exon 9 (AYins503-504, IC₅₀= 18 nM) and exon 11 (V560 D, IC₅₀= 5 nM; Δ552-559, IC₅₀= 1 nM). Motesanib also demonstrated activity against kinase domain mutations conferring imatinib resistance (V560D/V654A, IC₅₀= 77 nM; V560D/T670I, IC₅₀= 277 nM; Y823 D, IC₅₀= 64 nM) but failed to inhibit the imatinib-resistant D816V mutant (IC₅₀> 3000 nM). Motesanib suppressed the proliferation of Ba/F3 cells expressing Kit mutants with IC₅₀values in good agreement with those observed in the autophosphorylation assays.</p> <p>Conclusions</p> <p>In conclusion, our data suggest that motesanib possesses inhibitory activity against primary Kit mutations and some imatinib-resistant secondary mutations.</p

Earthquake data report for LARSE II – High Resolution, Santa Monica, California

[no abstract

Fine-scale structure of the San Andreas fault zone and location of the SAFOD target earthquakes

We present results from the tomographic analysis of seismic data from the Parkfield area using three different inversion codes. The models provide a consistent view of the complex velocity structure in the vicinity of the San Andreas, including a sharp velocity contrast across the fault. We use the inversion results to assess our confidence in the absolute location accuracy of a potential target earthquake. We derive two types of accuracy estimates, one based on a consideration of the location differences from the three inversion methods, and the other based on the absolute location accuracy of ‘‘virtual earthquakes.’’ Location differences are on the order of 100–200 m horizontally and up to 500 m vertically. Bounds on the absolute location errors based on the ‘‘virtual earthquake’’ relocations are ~50 m horizontally and vertically. The average of our locations places the target event epicenter within about 100 m of the SAF surface trace

Design and implementation of a visual query language for large spatial databases

In this paper a visual approach to querying in large spatial databases is presented. A diagrammatic technique utilising a data flow metaphor is used to express different kinds of spatial and non-spatial constraints. Basic filters are designed to represent the various types of queries in such systems. Icons for different types of spatial relations are used to denote the filters. Different granularities of the relations are presented in a hierarchical fashion when selecting the spatial constraints. The language constructs are presented and examples are used to demonstrate the expressiveness of the approach in representing different kinds of queries, including spatial joins and composite spatial queries. The implementation prototype of the language is also described and its features evaluated against a general purpose GIS package