Kinesin Light Chains Are Essential for Axonal Transport in Drosophila

Kinesin is a heterotetramer composed of two 115-kD heavy chains and two 58-kD light chains. The microtubule motor activity of kinesin is performed by the heavy chains, but the functions of the light chains are poorly understood. Mutations were generated in the Drosophila gene Kinesin light chain (Klc), and the phenotypic consequences of loss of Klc function were analyzed at the behavioral and cellular levels. Loss of Klc function results in progressive lethargy, crawling defects, and paralysis followed by death at the end of the second larval instar. Klc mutant axons contain large aggregates of membranous organelles in segmental nerve axons. These aggregates, or organelle jams (Hurd, D.D., and W.M. Saxton. 1996. Genetics. 144: 1075-1085), contain synaptic vesicle precursors as well as organelles that may be transported by kinesin, kinesin-like protein 68D, and cytoplasmic dynein, thus providing evidence that the loss of Klc function blocks multiple pathways of axonal transport. The similarity of the Klc and Khc ((Saxton et al. Cell 64:1093-1102; Hurd, D.D., and W.M. Saxton. 1996. Genetics 144: 1075-1085) mutant phenotypes indicates that KLC is essential for kinesin function, perhaps by tethering KHC to intracellular cargos or by activating the kinesin motor

Entrepreneurship and economic development in cities

Policy makers have identified the relationship between entrepreneurship and economic development. Yet, little is known about how this relationship varies over time in cities with different market sizes. This study examines the link between entrepreneurship and economic development using a panel of 127 European cities between 1994 and 2009. We found that the immediate economic development impact of new firm start-ups is positive for both small-/medium-size cities and large cities. The relationship is U-shaped for large cities, with the indirect effect taking 7 years, but the indirect effect does not occur in small-/medium-size cities. We offer useful information for policy makers, practitioners, and scholars

Human-mobility-based sensor context-aware routing protocol for delay-tolerant data gathering in multi-sink cell-phone-based sensor networks

Ubiquitous use of cell phones encourages development of novel applications with sensors embedded in cell phones. The collection of information generated by these devices is a challenging task considering volatile topologies and energy-based scarce resources. Further, the data delivery to the sink is delay tolerant. Mobility of cell phones is opportunistically exploited for forwarding sensor generated data towards the sink. Human mobility model shows truncated power law distribution of flight length, pause time, and intercontact time. The power law behavior of inter-contact time often discourages routing of data using naive forwarding schemes. This work exploits the flight length and the pause time distributions of human mobility to design a better and efficient routing strategy. We propose a Human-Mobility-based Sensor Context-Aware Routing protocol (HMSCAR), which exploits human mobility patterns to smartly forward data towards the sink basically comprised of wi-fi hot spots or cellular base stations. The simulation results show that HMSCAR significantly outperforms the SCAR, SFR, and GRAD-MOB on the aspects of delivery ratio and time delay. A multi-sink scenario and single-copy replication scheme is assumed

Complex networks generated by the Penna bit-string model: emergence of small-world and assortative mixing

The Penna bit-string model successfully encompasses many phenomena of population evolution, including inheritance, mutation, evolution, and aging. If we consider social interactions among individuals in the Penna model, the population will form a complex network. In this paper, we first modify the Verhulst factor to control only the birth rate, and introduce activity-based preferential reproduction of offspring in the Penna model. The social interactions among individuals are generated by both inheritance and activity-based preferential increase. Then we study the properties of the complex network generated by the modified Penna model. We find that the resulting complex network has a small-world effect and the assortative mixing property

Solar Gamma Rays Powered by Secluded Dark Matter

Secluded dark matter models, in which WIMPs annihilate first into metastable mediators, can present novel indirect detection signatures in the form of gamma rays and fluxes of charged particles arriving from directions correlated with the centers of large astrophysical bodies within the solar system, such as the Sun and larger planets. This naturally occurs if the mean free path of the mediator is in excess of the solar (or planetary) radius. We show that existing constraints from water Cerenkov detectors already provide a novel probe of the parameter space of these models, complementary to other sources, with significant scope for future improvement from high angular resolution gamma-ray telescopes such as Fermi-LAT. Fluxes of charged particles produced in mediator decays are also capable of contributing a significant solar system component to the spectrum of energetic electrons and positrons, a possibility which can be tested with the directional and timing information of PAMELA and Fermi.Comment: 22 pages, 3 figure

Significance of Dashavidhapareeksha in Panchakarma

Ayurveda is the science of health and diseased free life. It is fulfilled with guidelines which, if followed properly and regularly, would spare the agony of diseases. It is based on sound of principles of diagnosis. It requires comparatively less clinical or costly investigations. Pariksha is an important clinical tool for assessment of the Roga and Rogi Bala. Panchakarma which is essence and beauty of Ayurveda, is comprised of five unique procedures which are very effective especially for the management of various diseases such as lifestyle disorders. Dashavidha Pariksha is mentioned by Acharya Charaka which is a crucial art of examination. These are the comprehensive examination for biological and spiritual review of patient and most significant as it encompasses all other type of examination of patient and ailments. These are the very essential to know the nature of the disease and status of the patient before deciding any treatment protocol or before administration of any medicine. Dashavidha Pariksha should be assessed and taken into consideration while implementation of Panchakarma since output of panchakarma practices depends upon Ama, Agni and Tridoshas.  So, these are the fundamental tool for the Panchakarma practices for its selection. This study is an attempt to establish the applicability of Dashavidha Pareeksha in Panchakarma practice

Chip equalized adaptive rake receiver for DS-CDMA UWB systems

Conventional Rake receiver is a popular and effective method of utilizing the diversity offered by a DS-CDMA and multipath communication channel. The proposed Rake receiver is useful for suppression of multiple access interference in a multipath channel. The receiver works on chip level equalization on each Rake finger to cancel multi-access interference. Simulation results show that the convergence, diversity gain and bit error probability performance of the proposed receiver is much better than conventional adaptive Rake receiver in multipath channels

Frequency and time hopping PPM UWB multiple access communication scheme

In this paper we propose frequency and time hopping pulse position modulation (FTH-PPM) ultra wideband (UWB) for multiple access communications.We have derived and investigated the bit error probability for the multi-user synchronous transmitter case in multipath channels with Additive White Gaussian Noise (AWGN). Simulation results show that bit error probability performance of FTH-PPM UWB out performs the time hopping pulse position modulated (TH-PPM) UWB system. It also show that multiuser capacity of FTH-PPM UWB system is much better than TH-PPM UWB system

The Spectral Energy Distribution and Infrared Luminosities of z ≈ 2 Dust-obscured Galaxies from Herschel and Spitzer

Dust-obscured galaxies (DOGs) are a subset of high-redshift (z ≈ 2) optically-faint ultra-luminous infrared galaxies (ULIRGs, e.g., L_(IR) > 10^(12) L_☉). We present new far-infrared photometry, at 250, 350, and 500 μm (observed-frame), from the Herschel Space Telescope for a large sample of 113 DOGs with spectroscopically measured redshifts. Approximately 60% of the sample are detected in the far-IR. The Herschel photometry allows the first robust determinations of the total infrared luminosities of a large sample of DOGs, confirming their high IR luminosities, which range from 10^(11.6) L_☉ 10^(13) L_☉. The rest-frame near-IR (1-3 μm) spectral energy distributions (SEDs) of the Herschel-detected DOGs are predictors of their SEDs at longer wavelengths. DOGs with "power-law" SEDs in the rest-frame near-IR show observed-frame 250/24 μm flux density ratios similar to the QSO-like local ULIRG, Mrk 231. DOGs with a stellar "bump" in their rest-frame near-IR show observed-frame 250/24 μm flux density ratios similar to local star-bursting ULIRGs like NGC 6240. None show 250/24 μm flux density ratios similar to extreme local ULIRG, Arp 220; though three show 350/24 μm flux density ratios similar to Arp 220. For the Herschel-detected DOGs, accurate estimates (within ~25%) of total IR luminosity can be predicted from their rest-frame mid-IR data alone (e.g., from Spitzer observed-frame 24 μm luminosities). Herschel-detected DOGs tend to have a high ratio of infrared luminosity to rest-frame 8 μm luminosity (the IR8 = L_(IR)(8-1000 μm)/νL_ν(8 μm) parameter of Elbaz et al.). Instead of lying on the z = 1-2 "infrared main sequence" of star-forming galaxies (like typical LIRGs and ULIRGs at those epochs) the DOGs, especially large fractions of the bump sources, tend to lie in the starburst sequence. While, Herschel-detected DOGs are similar to scaled up versions of local ULIRGs in terms of 250/24 μm flux density ratio, and IR8, they tend to have cooler far-IR dust temperatures (20-40 K for DOGs versus 40-50 K for local ULIRGs) as measured by the rest-frame 80/115 μm flux density ratios (e.g., observed-frame 250/350 μm ratios at z = 2). DOGs that are not detected by Herschel appear to have lower observed-frame 250/24 μm ratios than the detected sample, either because of warmer dust temperatures, lower IR luminosities, or both