67 research outputs found
Effects of Fermi energy, dot size and leads width on weak localization in chaotic quantum dots
Magnetotransport in chaotic quantum dots at low magnetic fields is
investigated by means of a tight binding Hamiltonian on L x L clusters of the
square lattice. Chaoticity is induced by introducing L bulk vacancies. The
dependence of weak localization on the Fermi energy, dot size and leads width
is investigated in detail and the results compared with those of previous
analyses, in particular with random matrix theory predictions. Our results
indicate that the dependence of the critical flux Phi_c on the square root of
the number of open modes, as predicted by random matrix theory, is obscured by
the strong energy dependence of the proportionality constant. Instead, the size
dependence of the critical flux predicted by Efetov and random matrix theory,
namely, Phi_c ~ sqrt{1/L}, is clearly illustrated by the present results. Our
numerical results do also show that the weak localization term significantly
decreases as the leads width W approaches L. However, calculations for W=L
indicate that the weak localization effect does not disappear as L increases.Comment: RevTeX, 8 postscript figures include
The Thermopower of Quantum Chaos
The thermovoltage of a chaotic quantum dot is measured using a current
heating technique. The fluctuations in the thermopower as a function of
magnetic field and dot shape display a non-Gaussian distribution, in agreement
with simulations using Random Matrix Theory. We observe no contributions from
weak localization or short trajectories in the thermopower.Comment: 4 pages, 3 figures, corrected: accidently omitted author in the
Authors list, here (not in the article
Ballistic Transport Through Chaotic Cavities: Can Parametric Correlations and the Weak Localization Peak be Described by a Brownian Motion Model?
A Brownian motion model is devised on the manifold of S-matrices, and applied
to the calculation of conductance-conductance correlations and of the weak
localization peak. The model predicts that (i) the correlation function in
has the same shape and width as the weak localization peak; (ii) the functions
behave as , thus excluding a linear line shape; and
(iii) their width increases as the square root of the number of channels in the
leads. Some of these predictions agree with experiment and with other
calculations only in the limit of small and a large number of channels.Comment: 5 pages revtex (twocolumn
How Phase-Breaking Affects Quantum Transport Through Chaotic Cavities
We investigate the effects of phase-breaking events on electronic transport
through ballistic chaotic cavities. We simulate phase-breaking by a fictitious
lead connecting the cavity to a phase-randomizing reservoir and introduce a
statistical description for the total scattering matrix, including the
additional lead. For strong phase-breaking, the average and variance of the
conductance are calculated analytically. Combining these results with those in
the absence of phase-breaking, we propose an interpolation formula, show that
it is an excellent description of random-matrix numerical calculations, and
obtain good agreement with several recent experiments.Comment: 4 pages, revtex, 3 figures: uuencoded tar-compressed postscrip
Extremal projectors for contragredient Lie (super)symmetries (short review)
A brief review of the extremal projectors for contragredient Lie
(super)symmetries (finite-dimensional simple Lie algebras, basic classical Lie
superalgebras, infinite-dimensional affine Kac-Moody algebras and
superalgebras, as well as their quantum -analogs) is given. Some
bibliographic comments on the applications of extremal projectors are
presented.Comment: 21 pages, LaTeX; typos corrected, references adde
Signatures of Chaos in the Statistical Distribution of Conductance Peaks in Quantum Dots
Analytical expressions for the width and conductance peak distributions of
irregularly shaped quantum dots in the Coulomb blockade regime are presented in
the limits of conserved and broken time-reversal symmetry. The results are
obtained using random matrix theory and are valid in general for any number of
non-equivalent and correlated channels, assuming that the underlying classical
dynamic of the electrons in the dot is chaotic or that the dot is weakly
disordered. The results are expressed in terms of the channel correlation
matrix which for chaotic systems is given in closed form for both point-like
contacts and extended leads. We study the dependence of the distributions on
the number of channels and their correlations. The theoretical distributions
are in good agreement with those computed in a dynamical model of a chaotic
billiard.Comment: 19 pages, RevTex, 11 Postscript figure
Human Flt3L Generates Dendritic Cells from Canine Peripheral Blood Precursors: Implications for a Dog Glioma Clinical Trial
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and carries a dismal prognosis. We have developed a conditional cytotoxic/immunotherapeutic approach using adenoviral vectors (Ads) encoding the immunostimulatory cytokine, human soluble fms-like tyrosine kinase 3 ligand (hsFlt3L) and the conditional cytotoxic molecule, i.e., Herpes Simplex Type 1- thymide kinase (TK). This therapy triggers an anti-tumor immune response that leads to tumor regression and anti-tumor immunological memory in intracranial rodent cancer models. We aim to test the efficacy of this immunotherapy in dogs bearing spontaneous GBM. In view of the controversy regarding the effect of human cytokines on dog immune cells, and considering that the efficacy of this treatment depends on hsFlt3L-stimulated dendritic cells (DCs), in the present work we tested the ability of Ad-encoded hsFlt3L to generate DCs from dog peripheral blood and compared its effects with canine IL-4 and GM-CSF.Our results demonstrate that hsFlT3L expressed form an Ad vector, generated DCs from peripheral blood cultures with very similar morphological and phenotypic characteristics to canine IL-4 and GM-CSF-cultured DCs. These include phagocytic activity and expression of CD11c, MHCII, CD80 and CD14. Maturation of DCs cultured under both conditions resulted in increased secretion of IL-6, TNF-alpha and IFN-gamma. Importantly, hsFlt3L-derived antigen presenting cells showed allostimulatory potential highlighting their ability to present antigen to T cells and elicit their proliferation.These results demonstrate that hsFlt3L induces the proliferation of canine DCs and support its use in upcoming clinical trials for canine GBM. Our data further support the translation of hsFlt3L to be used for dendritic cells' vaccination and gene therapeutic approaches from rodent models to canine patients and its future implementation in human clinical trials
Looked after young people and their social work managers: a study of contrasting experiences of using computer-assisted-self-interviewing (A-CASI)
Audio-computer-assisted-self-interviewing (A-CASI) is used by many child-care agencies in the UK, as a way of recording the views of children in the care of local authorities. This study considers A-CASI’s use in two such local authorities in England. It contrasts how the A-CASI methodology is experienced by children and young people and by child-care managers, and explores how A-CASI may be contributing to the participation of young people in the delivery and management of their care. The study reveals a strong belief in A-CASI from a large number of participants, young people and managers. But managers express concern about many organizational constraints on the effective use of A-CASI data in their agencies. The paper discusses the enthusiasm of the young people for using A-CASI; the concerns of managers; and the opportunities for social workers in using A-CASI in their practice settings
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