20 research outputs found
Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells
Chlamydophila pneumoniae causes acute respiratory tract infections and has been associated with development of asthma and atherosclerosis. The production of IL-1β, a key mediator of acute and chronic inflammation, is regulated on a transcriptional level and additionally on a posttranslational level by inflammasomes. In the present study we show that C. pneumoniae-infected human mononuclear cells produce IL-1β protein depending on an inflammasome consisting of NLRP3, the adapter protein ASC and caspase-1. We further found that the small GTPase Rac1 is activated in C. pneumoniae-infected cells. Importantly, studies with specific inhibitors as well as siRNA show that Rac1 regulates inflammasome activation in C. pneumoniae-infected cells. In conclusion, C. pneumoniae infection of mononuclear cells stimulates IL-1β production dependent on a NLRP3 inflammasome-mediated processing of proIL-1β which is controlled by Rac1
NEW TECHNOLOGIES OF MATERIAL PROCESSING FOR RESTORATION OF PERSON SUPPORT-MOTOR FUNCTIONS
The works on production and providing of medical prophylactic institutions of the republic with implants, instruments and devices for treatment of orthopedic-traumatologic patients are carried out at the enterprise UP '‘Technopark BNTU ''Metolit
Twenty years of fuzzy preference structures (1978–1997)
de Morgan triplet, fuzzy relation, fuzzy preference structure, incomparability, indifference, strict preference, t-norm,