Personnel techniques necessary to maximize bio-barrier integrity at a Martian receiving laboratory

The planning of biological isolation measures for the Mars Surface Sample Return Mission is discussed in terms of personnel and organizational management. Deficiencies in past operation of the Lunar Receiving Laborator are analyzed. It was found that the failure to clearly define relationship among the government agencies involved and to effectively integrate their objectives and responsibilities was a major cause of Laboratory deficiencies. Possible solutions to these problems are presented for application to future missions

HEAO 3 upper limits to the expected 1634 KeV line from SS 483

A model based on 24 Mg(1369) was developed as the source of the lines in which refractory grains in the jets, containing Mg and 0, are bombarded, by ambient protons in the local ISM. The narrowness of the features results because the recoil Mg nucleus is stopped in the grain before the 1369 keV excited state decays. A consequence of the 24 Mg interpretation is the expected appearance of other emission lines, due to 20 Ne and 20 Na, which are produced by proton bombardment of 24 Mg at the 33 MeV/nucleon energy corresponding to the velocity of the jets. These lines appear at rest energies of 1634 keV and 1636 keV, respectively, and should have essentially the same total flux as that emited at 1369 keV. The HEAO 3 data are examined to search for the 1634 keV (rest) emission. The observation and analysis, the results, and the implications for the understanding of SS 433 are discussed

High-resolution spectrum of Cygnus X-1

A high resolution spectrum of Cygnus X-1 in the 45 to 600 keV range is presented. The measurement was made by the HEAO 3 gamma ray spectrometer during 82 days in the fall of 1979 and spring of 1980, when the source was in its normal low state. Results of a search for narrow emission lines from the source are reported. The spectrum shows no significant narrow features. The 3 delta upper limit to a narrow 511 keV annihilation line is 3 x 0.0001 photons/sq cm/s. There is also no evidence in HEAO 3 broadband data above 500 keV for the broad annihilation feature observed by HEAO 1

Gamma-ray burst variability above 4 MeV

The relationship between the hard X-ray and gamma ray emissions during four bursts using the anti-coincidence shields of the High Energy Astronomy Observatory 3 (HEAO 3) Gamma Ray Spectrometer is explored. Recent observations of gamma ray bursts by the Solar Maximum Mission Gamma Ray Spectrometer (GRS) have shown that high energy emission above 1 MeV is a common and energetically important feature (Matz et al. 1985). Time histories of four gamma ray bursts in 3 energy bands ( keV, around 511 keV, and 4 MeV) with 10.24 a resolution show that the 4 MeV flux is only weakly coupled to the spectrum below approximately 600 keV

Galactic distribution of interstellar Al-26

A narrow cosmic gamma ray line at 1809 keV was discovered which was interpreted as resulting from the decay of approximately 3 M sub theta of Al-26 residing in the galactic disk. While its intrinsic width was unresolved by the HEAO 3 spectrometer, a (1 sigma) limit of 3 keV FWHM was obtained; this corresponds to bulk motions of v 250 km/s, which is consistent with material at rest in the ISM. Sites which have been suggested include type II supernovae and massive stars which are members of the extreme population I, as well as novae and red giants which are associated with an older disk population. The HEAO 3 data was used to distinguish between these two stellar populations

Random Projections For Large-Scale Regression

Fitting linear regression models can be computationally very expensive in large-scale data analysis tasks if the sample size and the number of variables are very large. Random projections are extensively used as a dimension reduction tool in machine learning and statistics. We discuss the applications of random projections in linear regression problems, developed to decrease computational costs, and give an overview of the theoretical guarantees of the generalization error. It can be shown that the combination of random projections with least squares regression leads to similar recovery as ridge regression and principal component regression. We also discuss possible improvements when averaging over multiple random projections, an approach that lends itself easily to parallel implementation.Comment: 13 pages, 3 Figure

Monitoring What Governments “Give for” and “Spend on” Vaccine Procurement: Vaccine Procurement Assistance and Vaccine Procurement Baseline

Background: The Global Vaccine Action Plan will require, inter alia, the mobilization of financial resources from donors and national governments – both rich and poor. Vaccine Procurement Assistance (VPA) and Vaccine Procurement Baseline (VPB) are two metrics that could measure government performance and track resources in this arena. VPA is proposed as a new subcategory of Official Development Assistance (ODA) given for the procurement of vaccines and VPB is a previously suggested measure of the share of Gross Domestic Product (GDP) that governments spend on their own vaccine procurement. Objective: To determine realistic targets for VPA and VPB. Methods: Organization for Economic Co-Operation and Development (OECD) and World Bank data for 2009 were analyzed to determine the proportions of bilateral ODA from the 23 Development Assistance Committee (DAC) countries disbursed (as % of GDP in current US$) for infectious disease control. DAC country contributions to the GAVI Alliance for 2009 were assessed as a measure of multilateral donor support for vaccines and immunization programs. Findings: In 2009, total DAC bilateral ODA was 0.16$7.61 billion and 0.02% of the GDP of the poorest 117 countries was US$2.88 billion. Conclusions: Adopting 0.02% GDP as minimum targets for both VPA and VPB is based on realistic estimates of what both developed and developing countries should spend, and can afford to spend, to jointly ensure procurement of vaccines recommended by national and global bodies. New OECD purpose codes are needed to specifically track ODA disbursed for a) vaccine procurement; and b) immunization programs