Lining Design for Alborz Tunnel in Iran

The paper describes the application of analytical methods if tunnel linings design under static, tectonic and seismic effects for the design of the transport tunnel Albors in Iran. The methods are based on solutions of the corresponding plane problems of the elasticity theory simulating the initial stress fields in the rock mass caused by gravitational or tectonic forces and actions of long arbitrary directed longitudinal (P) and shear (S) waves propagating in the plane of the tunnel cross-section. For the design of tunnel linings under seismic effects the original approach has been applied consisting in the determination of maximal compressive and tensile circumferential stresses wich may appear in points of the lining internal outline at any combinations and directions of P- and S- waves

System UMD-104M for magnetic flaw detection and measuring of thickness tubing pipes re-use.

An optimal structural scheme and distinguishing features of a new automated system for magnetic flow detection in seamless and electric-welded tubing pipes in the process of pipe production and used pipe recovery were described. It was demonstrated that the application of modern nanotechnology for the manufacturing of single-chip thin-film matrix high-resolution converters can significantly increase the functionality of an inspection unit and provides not only a effective detection of all unacceptable defects such as metal discontinuity and wear of pipe walls, as well as the displacement of the weld edges but also higher sensor reliability ratio (minimum failures).Рассмотрена оптимальная структурная схема и отличительные особенности новой автоматизированной установки для магнитной дефектоскопии бесшовных и электросварных насосно-компрессорных труб в процессе их производства и при восстановлении труб, бывших в эксплуатации. Показано, что применение современных нанотехнологий для изготовления однокристальных тонкопленочных матричных преобразователей высокого разрешения позволяет существенно увеличить функциональные возможности дефектоскопа и обеспечивает не только уверенное выявление всех недопустимых дефектов типа нарушений сплошности металла и износа стенки труб, а также смещений кромок сварного шва, но и более высокие показатели по надежности датчиков (отказы минимальные)

Computing Nash Equilibrium in Wireless Ad Hoc Networks: A Simulation-Based Approach

This paper studies the problem of computing Nash equilibrium in wireless networks modeled by Weighted Timed Automata. Such formalism comes together with a logic that can be used to describe complex features such as timed energy constraints. Our contribution is a method for solving this problem using Statistical Model Checking. The method has been implemented in UPPAAL model checker and has been applied to the analysis of Aloha CSMA/CD and IEEE 802.15.4 CSMA/CA protocols.Comment: In Proceedings IWIGP 2012, arXiv:1202.422

Monkeypox Virus Dissemination in Case of Intranasal Infection of Mice

By the experiments of in vivo intranasal infection of 8-10-days-old outbread ICR mice with Monkeypox virus (MPV) in a dose equal 3.83 lg FFU/specimen, investigated was dynamics of the virus accumulation within various organs, blood cells, and blood serum. In 2 days after infection MPV was detected in blood cells, nasal cavity, lungs, spleen, and duodenum, and in 5 days after - in brain, trachea, liver, kidneys, and blood serum. It was established that 7 days after infection the highest level of MPV production was in the lungs, nasal cavity, and brain, where virus titers in 5 % homogenates were (5.7±0.1), (5.5±0.1), and (5.3±0.3) lg FFU/ml, respectively. In the blood cells virus was traced in 2, 5, and 7 days after challenge, while in blood serum - in 5 and 7 days. MPV blood transfer to the secondary target organs (liver, spleen, duodenum, kidneys, et al. ) was operational, probably, due to the virus proliferation in blood corpuscles. The data obtained and the worked out scheme of MPV dissemination in an organism can be used for the selection and construction of therapeutic anti-pox virus preparations with precise targeted drug delivery

Mice as Animal Model for Evaluation of Therapeutic Efficacy of Preparations against Monkeypox

of MPV after 7 days postinfection, applying peroral administration once within 24 hours (24 hours before infection and 7 days after infection of mouse with 60 µg/g of a preparation). Displayed is the feasibility of using 8–15-days-old ICR mice (body weight 9–11 g) as an animal model for evaluation of therapeutic efficacy of the preparations under development against Monkeypox and smallpox

Sensitivity of Different Animal Species to Monkeypox Virus

Studied is the sensitivity of different animal species (white mice, rabbits, mini-pigs, and marmots) to Monkeypox virus (MPXV). Determined is the fact that MPXV-sensitive are groundhogs (ID50 and LD50 5 lg of PFU in case of intranasal inoculation). The most pronounced clinical signs of the disease such as varioliform eruption all over body and mucous linings, purulent discharges out of nasal cavity, lymphadenitis, loss of coordination, tremor of extremities, fever, hyper-aggressiveness, disheveled hair have been registered in groundhogs. The highest viral loads in the majority of fallen marmots have been observed in nasal mucosa, trachea, lungs, and pock-marked skin (>6,0 lg PFU/g). The symptomatology of the disease in mice as compared to groundhogs is a bit milder: purulent conjunctivitis, blepharitis, and disheveled hair. As for mini-pigs and rabbits, no visual signs of the disease have been observed in them

Antiviral Activity of Extracts from Basidiomycetes for Orthopoxviruses

Carried out was evaluation of the effect of water extracts from basidiomycetes in Vero cell culture on variola virus, and vaccinia virus. Antiviral effect demonstrated Inonotus obliquus (Chaga), befungin and melanin from chaga, Ganoderma applanatum (Artist’s Bracket) , Fomitopsis officinalis (Larch Fungus)