Concise theory of chiral lipid membranes

A theory of chiral lipid membranes is proposed on the basis of a concise free energy density which includes the contributions of the bending and the surface tension of membranes, as well as the chirality and orientational variation of tilting molecules. This theory is consistent with the previous experiments [J.M. Schnur \textit{et al.}, Science \textbf{264}, 945 (1994); M.S. Spector \textit{et al.}, Langmuir \textbf{14}, 3493 (1998); Y. Zhao, \textit{et al.}, Proc. Natl. Acad. Sci. USA \textbf{102}, 7438 (2005)] on self-assembled chiral lipid membranes of DC$_{8,9}$PC. A torus with the ratio between its two generated radii larger than $\sqrt{2}$ is predicted from the Euler-Lagrange equations. It is found that tubules with helically modulated tilting state are not admitted by the Euler-Lagrange equations, and that they are less energetically favorable than helical ripples in tubules. The pitch angles of helical ripples are theoretically estimated to be about 0$^\circ$ and 35$^\circ$, which are close to the most frequent values 5$^\circ$ and 28$^\circ$ observed in the experiment [N. Mahajan \textit{et al.}, Langmuir \textbf{22}, 1973 (2006)]. Additionally, the present theory can explain twisted ribbons of achiral cationic amphiphiles interacting with chiral tartrate counterions. The ratio between the width and pitch of twisted ribbons is predicted to be proportional to the relative concentration difference of left- and right-handed enantiomers in the low relative concentration difference region, which is in good agreement with the experiment [R. Oda \textit{et al.}, Nature (London) \textbf{399}, 566 (1999)].Comment: 14 pages, 7 figure

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain

<p>Abstract</p> <p>Background</p> <p>Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain regions associated with the disease. Monoamine transmitters activate multiple signaling cascades some of which have been investigated as potential mediators of depression or antidepressant drug action. However, the diacylglycerol arm of phosphoinositide signaling cascades has not been systematically investigated, even though downstream targets of this cascade have been implicated in depression. With the ultimate goal of uncovering the primary postsynaptic actions that may initiate cellular antidepressive signaling, we have examined the antidepressant-induced production of CDP-diacylglycerol which is both a product of diacylglycerol phosphorylation and a precursor for the synthesis of physiologically critical glycerophospholipids such as the phosphatidylinositides. For this, drug effects on [³H]cytidine-labeled CDP-diacylglycerol and [³H]inositol-labeled phosphatidylinositides were measured in response to the tricyclics desipramine and imipramine, the selective serotonin reuptake inhibitors fluoxetine and paroxetine, the atypical antidepressants maprotiline and nomifensine, and several monoamine oxidase inhibitors.</p> <p>Results</p> <p>Multiple compounds from each antidepressant category significantly stimulated [³H]CDP-diacylglycerol accumulation in cerebrocortical, hippocampal, and striatal tissues, and also enhanced the resynthesis of inositol phospholipids. Conversely, various antipsychotics, anxiolytics, and non-antidepressant psychotropic agents failed to significantly induce CDP-diacylglycerol or phosphoinositide synthesis. Drug-induced CDP-diacylglycerol accumulation was independent of lithium and only partially dependent on phosphoinositide hydrolysis, thus indicating that antidepressants can mobilize CDP-diacylglycerol from additional pools lying outside of the inositol cycle. Further, unlike direct serotonergic, muscarinic, or α-adrenergic agonists that elicited comparable or lower effects on CDP-diacylglycerol versus inositol phosphates, the antidepressants dose-dependently induced significantly greater accumulations of CDP-diacylglycerol.</p> <p>Conclusion</p> <p>Chemically divergent antidepressant agents commonly and significantly enhanced the accumulation of CDP-diacylglycerol. The latter is not only a derived product of phosphoinositide hydrolysis but is also a crucial intermediate in the biosynthesis of several signaling substrates. Hence, altered CDP-diacylglycerol signaling might be implicated in the pathophysiology of depression or the mechanism of action of diverse antidepressant medications.</p

Photon bunching in parametric down-conversion with continuous wave excitation

The first direct measurement of photon bunching (g2 correlation function) in one output arm of a spontaneous-parametric-down-conversion source operated with a continuous pump laser in the single-photon regime is demonstrated. The result is in agreement with the statistics of a thermal field of the same coherence length, and shows the feasibility of investigating photon statistics with compact cw-pumped sources. Implications for entanglement-based quantum cryptography are discussed.Comment: 7 pages, 4 figures, expanded introduction and experimental details added. Accepted for publication in Phys.Rev.

Resistive damping implementation as a method to improve controllability in stiff ohmic RF-MEMS switches

This paper presents in detail the entire procedure of calculating the bias resistance of an ohmic RF-MEMS switch, controlled under resistive damping (charge drive technique). In case of a very stiff device, like the North Eastern University switch, the actuation control under resistive damping is the only way to achieve controllability. Due to the short switching time as well as the high actuation voltage, it is not practical to apply a tailored control pulse (voltage drive control technique). Implementing a bias resistor of 33 MΩ in series with the voltage source, the impact velocity of the cantilever has been reduced 80 % (13.2 from 65.9 cm/s), eliminating bouncing and high initial impact force during the pull-down phase. However, this results in an affordable cost of switching time increase from 2.38 to 4.34 μs. During the release phase the amplitude of bouncing has also been reduced 34 % (174 from 255 nm), providing significant improvement in both switching operation phases of the switch. © 2013 Springer-Verlag Berlin Heidelberg

Electric Current Focusing Efficiency in Graphene Electric Lens

In present work, we theoretically study the electron wave's focusing phenomenon in a single layered graphene pn junction(PNJ) and obtain the electric current density distribution of graphene PNJ, which is in good agreement with the qualitative result in previous numerical calculations [Science, 315, 1252 (2007)]. In addition, we find that for symmetric PNJ, 1/4 of total electric current radiated from source electrode can be collected by drain electrode. Furthermore, this ratio reduces to 3/16 in a symmetric graphene npn junction. Our results obtained by present analytical method provide a general design rule for electric lens based on negative refractory index systems.Comment: 13 pages, 7 figure

Transmission of High-Power Electron Beams Through Small Apertures

Tests were performed to pass a 100 MeV, 430 kWatt c.w. electron beam from the energy-recovery linac at the Jefferson Laboratory's FEL facility through a set of small apertures in a 127 mm long aluminum block. Beam transmission losses of 3 p.p.m. through a 2 mm diameter aperture were maintained during a 7 hour continuous run.Comment: arXiv admin note: text overlap with arXiv:1305.019

Dynamic disorder in receptor-ligand forced dissociation experiments

Recently experiments showed that some biological noncovalent bonds increase their lifetimes when they are stretched by an external force, and their lifetimes will decrease when the force increases further. Several specific quantitative models have been proposed to explain the intriguing transitions from the "catch-bond" to the "slip-bond". Different from the previous efforts, in this work we propose that the dynamic disorder of the force-dependent dissociation rate can account for the counterintuitive behaviors of the bonds. A Gaussian stochastic rate model is used to quantitatively describe the transitions observed recently in the single bond P-selctin glycoprotein ligand 1(PSGL-1)$-$P-selectin force rupture experiment [Marshall, {\it et al.}, (2003) Nature {\bf 423}, 190-193]. Our model agrees well to the experimental data. We conclude that the catch bonds could arise from the stronger positive correlation between the height of the intrinsic energy barrier and the distance from the bound state to the barrier; classical pathway scenario or {\it a priori} catch bond assumption is not essential.Comment: 4 pages, 2 figure

Entanglement and interference between different degrees of freedom of photons states

In this paper, photonic entanglement and interference are described and analyzed with the language of quantum information process. Correspondingly, a photon state involving several degrees of freedom is represented in a new expression based on the permutation symmetry of bosons. In this expression, each degree of freedom of a single photon is regarded as a qubit and operations on photons as qubit gates. The two-photon Hong-Ou-Mandel interference is well interpreted with it. Moreover, the analysis reveals the entanglement between different degrees of freedom in a four-photon state from parametric down conversion, even if there is no entanglement between them in the two-photon state. The entanglement will decrease the state purity and photon interference visibility in the experiments on a four-photon polarization state.Comment: 11 pages and 2 figure

Second variation of the Helfrich-Canham Hamiltonian and reparametrization invariance

A covariant approach towards a theory of deformations is developed to examine both the first and second variation of the Helfrich-Canham Hamiltonian -- quadratic in the extrinsic curvature -- which describes fluid vesicles at mesoscopic scales. Deformations are decomposed into tangential and normal components; At first order, tangential deformations may always be identified with a reparametrization; at second order, they differ. The relationship between tangential deformations and reparametrizations, as well as the coupling between tangential and normal deformations, is examined at this order for both the metric and the extrinsic curvature tensors. Expressions for the expansion to second order in deformations of geometrical invariants constructed with these tensors are obtained; in particular, the expansion of the Hamiltonian to this order about an equilibrium is considered. Our approach applies as well to any geometrical model for membranes.Comment: 20 page