55,112 research outputs found

    Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis.

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    ObjectivesThiamin deficiency is highly prevalent in patients with sepsis, but the mechanism by which sepsis induces thiamin deficiency is unknown. This study aimed to determine the influence of various severity of sepsis on carrier-mediated intestinal thiamin uptake, level of expressions of thiamin transporters (thiamin transporter-1 and thiamin transporter-2), and mitochondrial thiamin pyrophosphate transporter.DesignRandomized controlled study.SettingResearch laboratory at a Veterans Affairs Medical Center.SubjectsTwenty-four Sprague-Dawley rats were randomized into controls, mild, moderate, and severe sepsis with equal number of animals in each group.InterventionsSepsis was induced by cecal ligation and puncture with the cecum ligated below the cecal valve at 25%, 50%, and 75% of cecal length, defined as severe, moderate, and mild sepsis, respectively. Control animals underwent laparotomy only.Measurements and main resultsAfter 2 days of induced sepsis, carrier-mediated intestinal thiamin uptake was measured using [H]thiamin. Expressions of thiamin transporter-1, thiamin transporter-2, and mitochondrial thiamin pyrophosphate transporter proteins and messenger RNA were measured. Proinflammatory cytokines (interleukin-1β and interleukin-6) and adenosine triphosphate were also measured. Sepsis inhibited [H]thiamin uptake, and the inhibition was a function of sepsis severity. Both cell membrane thiamin transporters and mitochondrial thiamin pyrophosphate transporter expression levels were suppressed; also levels of adenosine triphosphate in the intestine of animals with moderate and severe sepsis were significantly lower than that of sham-operated controls.ConclusionsFor the first time, we demonstrated that sepsis inhibited carrier-mediated intestinal thiamin uptake as a function of sepsis severity, suppressed thiamin transporters and mitochondrial thiamin pyrophosphate transporter, leading to adenosine triphosphate depletion

    Transfer Learning for Multi-language Twitter Election Classification

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    Both politicians and citizens are increasingly embracing social media as a means to disseminate information and comment on various topics, particularly during significant political events, such as elections. Such commentary during elections is also of interest to social scientists and pollsters. To facilitate the study of social media during elections, there is a need to automatically identify posts that are topically related to those elections. However, current studies have focused on elections within English-speaking regions, and hence the resultant election content classifiers are only applicable for elections in countries where the predominant language is English. On the other hand, as social media is becoming more prevalent worldwide, there is an increasing need for election classifiers that can be generalised across different languages, without building a training dataset for each election. In this paper, based upon transfer learning, we study the development of effective and reusable election classifiers for use on social media across multiple languages. We combine transfer learning with different classifiers such as Support Vector Machines (SVM) and state-of-the-art Convolutional Neural Networks (CNN), which make use of word embedding representations for each social media post. We generalise the learned classifier models for cross-language classification by using a linear translation approach to map the word embedding vectors from one language into another. Experiments conducted over two election datasets in different languages show that without using any training data from the target language, linear translations outperform a classical transfer learning approach, namely Transfer Component Analysis (TCA), by 80% in recall and 25% in F1 measure

    Fokker-Planck type equations with Sobolev diffusion coefficients and BV drift coefficients

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    In this paper we give an affirmative answer to an open question mentioned in [Le Bris and Lions, Comm. Partial Differential Equations 33 (2008), 1272--1317], that is, we prove the well-posedness of the Fokker-Planck type equations with Sobolev diffusion coefficients and BV drift coefficients.Comment: 11 pages. The proof has been modifie

    On the Rates of Type Ia Supernovae in Dwarf and Giant Hosts with ROTSE-IIIb

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    We present a sample of 23 spectroscopically confirmed Type Ia supernovae that were discovered in the background of galaxy clusters targeted by ROTSE-IIIb and use up to 18 of these to determine the local (z = 0.05) volumetric rate. Since our survey is flux limited and thus biased against fainter objects, the pseudo-absolute magnitude distribution (pAMD) of SNeIa in a given volume is an important concern, especially the relative frequency of high to low-luminosity SNeIa. We find that the pAMD derived from the volume limited Lick Observatory Supernova Search (LOSS) sample is incompatible with the distribution of SNeIa in a volume limited (z<0.12) sub sample of the SDSS-II. The LOSS sample requires far more low-luminosity SNeIa than the SDSS-II can accommodate. Even though LOSS and SDSS-II have sampled different SNeIa populations, their volumetric rates are surprisingly similar. Using the same model pAMD adopted in the SDSS-II SNeIa rate calculation and excluding two high-luminosity SNeIa from our sample, we derive a rate that is marginally higher than previous low-redshift determinations. With our full sample and the LOSS pAMD our rate is more than double the canonical value. We also find that 5 of our 18 SNeIa are hosted by very low-luminosity (M_B > -16) galaxies, whereas only 1 out 79 nearby SDSS-II SNeIa have such faint hosts. It is possible that previous works have under-counted either low luminosity SNeIa, SNeIa in low luminosity hosts, or peculiar SNeIa (sometimes explicitly), and the total SNeIa rate may be higher than the canonical value.Comment: 18 pages; accepted for publication in The Astronomical Journa

    Orbital Dependent Phase Control in Ca2-xSrxRuO4

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    We present first-principles studies on the orbital states of the layered perovskites Ca2−x_{2-x}Srx_xRuO4_4. The crossover from antiferromagnetic (AF) Mott insulator for x<0.2x < 0.2 to nearly ferromagnetic (FM) metal at x=0.5x=0.5 is characterized by the systematic change of the xyxy orbital occupation. For the AF side (x<0.2x < 0.2), we present firm evidence for the xyxy ferro-orbital ordering. It is found that the degeneracy of t2gt_{2g} (or ege_g) states is lifted robustly due to the two-dimensional (2D) crystal-structure, even without the Jahn-Teller distortion of RuO6_6. This effect dominates, and the cooperative occupation of xyxy orbital is concluded. In contrast to recent proposals, the resulting electronic structure explains well both the observed X-ray absorption spectra and the double peak structure of optical conductivity. For the FM side (x=0.5x=0.5), however, the xyxy orbital with half filling opens a pseudo-gap in the FM state and contributes to the spin SS=1/2 moment (rather than SS=1 for xx=0.0 case) dominantly, while yz,zxyz,zx states are itinerant with very small spin polarization, explaining the recent neutron data consistently.Comment: 17 pages, 5 figure
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