1,660 research outputs found
Jet quenching in shock waves
We study the propagation of an ultrarelativistic light quark jet inside a
shock wave using the holographic principle. The maximum stopping distance and
its dependency on the energy of the jet is obtained
SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression
© 2015 Sin, Yung, Yip, Chan, Wong, Tam and Siu. Our current understanding on the molecular mechanisms by which sustained compression induces skeletal muscle injury is very limited. This study aimed to test the hypothesis that activation of SIRT1 by the natural antioxidant resveratrol could deactivate apoptotic and catabolic signaling in skeletal muscle exposed to moderate compression. Two cycles of 6-h constant pressure at 100 mmHg was applied to the tibialis region of right, but not left hindlimbs of Sprague Dawley rats pre-treated with DMSO (vehicle control) or resveratrol with/without sirtinol. Skeletal muscle tissues lying underneath and spatially corresponding to the compressed sites were collected for analyses. Resveratrol prevented the compression-induced manifestations of pathohistological damages including elevations of the number of interstitial nuclei and area of interstitial space and ameliorated oxidative damages measured as 4-hydroxy-2-nonenal (4HNE) and nitrotyrosine in skeletal muscle. In parallel, resveratrol augmented the expression level and activity of SIRT1 and phosphorylation levels of Foxo3a and Akt while suppressed the increases in protein abundances of p53, Bax, MAFbx, and ubiquitin, enzymatic activities of caspase 3 and 20S proteasome, and apoptotic DNA fragmentation in the compressed muscle. These favorable myoprotective effects of resveratrol were diminished upon pharmacological blockade of SIRT1 by using sirtinol. These novel data support the hypothesis that the anti-apoptotic and anti-catabolic effects of resveratrol on compression injury in skeletal muscle required the action of SIRT1.Link_to_subscribed_fulltex
Kaluza-Klein Higher Derivative Induced Gravity
The existence and stability analysis of an inflationary solution in a
-dimensional anisotropic induced gravity is presented in this paper.
Nontrivial conditions in the field equations are shown to be compatible with a
cosmological model in which the 4-dimension external space evolves
inflationary, while, the D-dimension internal one is static. In particular,
only two additional constraints on the coupling constants are derived from the
abundant field equations and perturbation equations. In addition, a compact
formula for the non-redundant 4+D dimensional Friedmann equation is also
derived for convenience. Possible implications are also discussed in this
paper.Comment: 13 pages, typos/errors corrected, three additional appendices adde
Shear viscosity, instability and the upper bound of the Gauss-Bonnet coupling constant
We compute the dimensionality dependence of for charged black branes
with Gauss-Bonnet correction. We find that both causality and stability
constrain the value of Gauss-Bonnet coupling constant to be bounded by 1/4 in
the infinite dimensionality limit. We further show that higher dimensionality
stabilize the gravitational perturbation. The stabilization of the perturbation
in higher dimensional space-time is a straightforward consequence of the
Gauss-Bonnet coupling constant bound.Comment: 16 pages,3 figures+3 tables,typos corrected, published versio
String compactification, QCD axion and axion-photon-photon coupling
It is pointed out that there exist a few problems to be overcome toward an
observable sub-eV QCD axion in superstring compactification. We give a general
expression for the axion decay constant. For a large domain wall number
, the axion decay constant can be substantially lowered from a generic
value of a scalar singlet VEV. The Yukawa coupling structure in the recent
model is studied completely, including the needed nonrenormalizable
terms toward realistic quark and lepton masses. In this model we find an
approximate global symmetry and vacuum so that a QCD axion results but its
decay constant is at the GUT scale. The axion-photon-photon coupling is
calculated for a realistic vacuum satisfying the quark and lepton mass matrix
conditions. It is the first time calculation of in
realistic string compactifications: .Comment: 33 pages, 2 figures, JHEP format, some errors in the superpotential
couplings are corrected and the following discussions are changed
correspondingl
Mixed RG Flows and Hydrodynamics at Finite Holographic Screen
We consider quark-gluon plasma with chemical potential and study
renormalization group flows of transport coefficients in the framework of
gauge/gravity duality. We first study them using the flow equations and compare
the results with hydrodynamic results by calculating the Green functions on the
arbitrary slice. Two results match exactly. Transport coefficients at arbitrary
scale is ontained by calculating hydrodynamics Green functions. When either
momentum or charge vanishes, transport coefficients decouple from each other.Comment: 22 pages, 6 figure
Holographic RG flow of the shear viscosity to entropy density ratio in strongly coupled anisotropic plasma
We study holographic RG flow of the shear viscosity tensor of anisotropic,
strongly coupled N=4 super-Yang-Mills plasma by using its type IIB supergravity
dual in anisotropic bulk spacetime. We find that the shear viscosity tensor has
three independent components in the anisotropic bulk spacetime away from the
boundary, and one of the components has a non-trivial RG flow while the other
two have a trivial one. For the component of the shear viscosity tensor with
non-trivial RG flow, we derive its RG flow equation, and solve the equation
analytically to second order in the anisotropy parameter 'a'. We derive the RG
equation using the equation of motion, holographic Wilsonian RG method, and
Kubo's formula. All methods give the same result. Solving the equation, we find
that the ratio of the component of the shear viscosity tensor to entropy
density 'eta/s' flows from above '1/4pi' at the horizon (IR) to below '1/4pi'
at the boundary (UV) where it violates the holographic shear viscosity
(Kovtun-Son-Starinets) bound and where it agrees with the other longitudinal
component.Comment: 17 pages, 2 figures, slight change on the title, more background
material added, references added, accepted for publication in JHE
Implications of MicroRNAs in the treatment of gefitinib-resistant non-small cell lung cancer
2015-2016 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
A Detailed Analysis of One-loop Neutrino Masses from the Generic Supersymmetric Standard Model
In the generic supersymmetric standard model which had no global symmetry
enforced by hand, lepton number violation is a natural consequence.
Supersymmetry, hence, can be considered the source of experimentally demanded
beyond standard model properties for the neutrinos. With an efficient
formulation of the model, we perform a comprehensive detailed analysis of all
one-loop contributions to neutrino masses.Comment: 27 pages Revtex, no figur
Dynamics of Baryons from String Theory and Vector Dominance
We consider a holographic model of QCD from string theory, a la Sakai and
Sugimoto, and study baryons. In this model, mesons are collectively realized as
a five-dimensional \ Yang-Mills field and baryons
are classically identified as solitons with a unit Pontryagin number
and electric charges. The soliton is shown to be very small in the large
't Hooft coupling limit, allowing us to introduce an effective field . Its coupling to the mesons are dictated by the soliton structure, and
consists of a direct magnetic coupling to the field strength as well
as a minimal coupling to the gauge field. Upon the dimensional
reduction, this effective action reproduces all interaction terms between
nucleons and an infinite tower of mesons in a manner consistent with the large
expansion. We further find that all electromagnetic interactions, as
inferred from the same effective action via a holographic prescription, are
mediated by an infinite tower of vector mesons, rendering the baryon
electromagnetic form factors completely vector-dominated as well. We estimate
nucleon-meson couplings and also the anomalous magnetic moments, which compare
well with nature.Comment: 65pages, 3 figures, vector mesons and axial-vector mesons are now
canonically normalized (comparisons with data and conclusions unaffected
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