20 research outputs found
Power Allocation and Cooperative Diversity in Two-Way Non-Regenerative Cognitive Radio Networks
In this paper, we investigate the performance of a dual-hop block fading
cognitive radio network with underlay spectrum sharing over independent but not
necessarily identically distributed (i.n.i.d.) Nakagami- fading channels.
The primary network consists of a source and a destination. Depending on
whether the secondary network which consists of two source nodes have a single
relay for cooperation or multiple relays thereby employs opportunistic relay
selection for cooperation and whether the two source nodes suffer from the
primary users' (PU) interference, two cases are considered in this paper, which
are referred to as Scenario (a) and Scenario (b), respectively. For the
considered underlay spectrum sharing, the transmit power constraint of the
proposed system is adjusted by interference limit on the primary network and
the interference imposed by primary user (PU). The developed new analysis
obtains new analytical results for the outage capacity (OC) and average symbol
error probability (ASEP). In particular, for Scenario (a), tight lower bounds
on the OC and ASEP of the secondary network are derived in closed-form. In
addition, a closed from expression for the end-to-end OC of Scenario (a) is
achieved. With regards to Scenario (b), a tight lower bound on the OC of the
secondary network is derived in closed-form. All analytical results are
corroborated using Monte Carlo simulation method
GEANT4 versus MCNP5: Monte-Carlo ophthalmic brachytherapy dosimetry in the presence of gold nanoparticles for 125I and 103Pd
Ocular Brachytherapy Dosimetry for103Pd and125I in The Presence of Gold Nanoparticles: Monte Carlo Study
Efficacy and safety of fibrinogen administration in acute post-traumatic hypofibrinogenemia in isolated severe traumatic brain injury: A randomized clinical trial
Aim: This study was conducted to evaluate clinical outcomes after fibrinogen administration in hypofibrinogenemia following severe traumatic brain injury. Background: Post traumatic coagulopathy (PTC) is a common but devastating medical condition in patients with severe head injury. Hypofibrinogenemia is considered as an indicator for poor clinical outcomes in traumatic brain injury (TBI). Methods: In this randomized clinical trial (RCT), primarily 137 patients with severe traumatic brain injury (Glasgow coma scale score: GCS 200 mg/dL) could improve GOSE, GCS score progression within 3 days after primary head injury and hematoma expansion controllability
10 Laser therapy of human choroidal Melanoma in the presence of gold nanoparticles - Monte Carlo and In Vitro Study
Laser therapy of human choroidal Melanoma in the presence of gold nanoparticles - Monte Carlo and In Vitro Study
CXCL13 Positive Cells Localization Predict Response to Anti-PD-1/PD-L1 in Pulmonary Non-Small Cell Carcinoma
Background: Immune checkpoint inhibitors (ICIs) have revolutionized non-small cell lung cancers (NSCLCs) treatment, but only 20–30% of patients benefit from these treatments. Currently, PD-L1 expression in tumor cells is the only clinically approved predictor of ICI response in lung cancer, but concerns arise due to its low negative and positive predictive value. Recent studies suggest that CXCL13+ T cells in the tumor microenvironment (TME) may be a good predictor of response. We aimed to assess if CXCL13+ cell localization within the TME can predict ICI response in advanced NSCLC patients. Methods: This retrospective study included 65 advanced NSCLC patients treated with Nivolumab/Pembrolizumab at IUCPQ or CHUM and for whom a pretreatment surgical specimen was available. Good responders were defined as having a complete radiologic response at 1 year, and bad responders were defined as showing cancer progression at 1 year. IHC staining for CXCL13 was carried out on a representative slide from a resection specimen, and CXCL13+ cell density was evaluated in tumor (T), invasive margin (IM), non-tumor (NT), and tertiary lymphoid structure (TLS) compartments. Cox models were used to analyze progression-free survival (PFS) and overall survival (OS) probability, while the Mann–Whitney test was used to compare CXCL13+ cell density between responders and non-responders. Results: We showed that CXCL13+ cell density localization within the TME is associated with ICI efficacy. An increased density of CXCL13+ cells across all compartments was associated with a poorer prognostic (OS; HR = 1.22; 95%CI = 1.04–1.42; p = 0.01, PFS; HR = 1.16; p = 0.02), or a better prognostic when colocalized within TLSs (PFS; HR = 0.84, p = 0.03). Conclusion: Our results support the role of CXCL13+ cells in advanced NSCLC patients, with favorable prognosis when localized within TLSs and unfavorable prognosis when present elsewhere. The concomitant proximity of CXCL13+ and CD20+ cells within TLSs may favor antigen presentation to T cells, thus enhancing the effect of PD-1/PD-L1 axis inhibition. Further validation is warranted to confirm the potential relevance of this biomarker in a clinical setting