625 research outputs found
Comments on the four-dimensional effective theory for warped compactification
We derive four-dimensional effective theories for warped compactification of
the ten-dimensional IIB supergravity and the eleven-dimensional Horava-Witten
model. We show that these effective theories allow a much wider class of
solutions than the original higher-dimensional theories. In particular, the
effective theories have cosmological solutions in which the size of the
internal space decreases with the cosmic expansion in the Einstein frame. This
type of compactifying solutions are not allowed in the original
higher-dimensional theories. This result indicates that the effective
four-dimensional theories should be used with caution, if one regards the
higher-dimensional theories more fundamental.Comment: 21 pages, no figure. Minor errors are correcte
Dynamics of Alpha-Helix Formation in the CSAW Model
We study the folding dynamics of polyalanine (Ala), a protein fragment
with 20 residues whose native state is a single alpha helix. We use the CSAW
model (conditioned self-avoiding walk), which treats the protein molecule as a
chain in Brownian motion, with interactions that include hydrophobic forces and
internal hydrogen bonding. We find that large scale structures form before
small scale structures, and obtain the relevant relaxation times. We find that
helix nucleation occurs at two separate points on the protein chain. The
evolution of small and large scale structures involve different mechanisms.
While the former can be describe by rate equations governing the growth of
helical content, the latter is akin to the relaxation of an elastic solid.Comment: 18 pages, 10 figure
Moduli Instability in Warped Compactifications of the Type IIB Supergravity
We show that the conifold and deformed-conifold warped compactifications of
the ten-dimensional type IIB supergravity, including the Klebanov-Strassler
solution, are dynamically unstable in the moduli sector representing the scale
of a Calabi-Yau space, although it can be practically stable for a quite long
time in a region with a large warp factor. This instability is associated with
complete supersymmetry breaking except for a special case and produces
significant time-dependence in the structure of the four-dimensional base
spacetime as well as of the internal space.Comment: 24 pages, no figure. Typos corrected, and some arguments in section 5
are adde
Spectrum from the warped compactifications with the de Sitter universe
We discuss the spectrum of the tensor metric perturbations and the stability
of warped compactifications with the de Sitter spacetime in the
higher-dimensional gravity. The spacetime structure is given in terms of the
warped product of the non-compact direction, the spherical internal dimensions
and the four-dimensional de Sitter spacetime. To realize a finite bulk volume,
we construct the brane world model, using the cut-copy-paste method. Then, we
compactify the spherical directions on the brane. In any case, we show the
existence of the massless zero mode and the mass gap of it with massive
Kaluza-Klein modes. Although the brane involves the spherical dimensions, no
light massive mode is excited. We also investigate the scalar perturbations,
and show that the model is unstable due to the existence of a tachyonic bound
state, which seems to have the universal negative mass square, irrespective of
the number of spacetime dimensions.Comment: Journal version (JHEP
Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica
<p>Abstract</p> <p>Background</p> <p>The role of different chemokine receptors in the pathogenesis of multiple sclerosis (MS) has been extensively investigated; however, little is known about the difference in the role of chemokine receptors between the pathogenesis of neuromyelitis optica (NMO) and MS. Therefore, we examined the expression of chemokine receptors on peripheral blood lymphocytes (PBL) in MS and NMO.</p> <p>Methods</p> <p>We used flow cytometry to analyse lymphocyte subsets in 12 patients with relapsing NMO, 24 with relapsing-remitting MS during relapse, 3 with NMO and 5 with MS during remission.</p> <p>Results</p> <p>Compared with healthy controls (HC), the percentage of lymphocytes in white blood cells was significantly lower in NMO and MS patients. The percentage of T cells expressing CD4<sup>+</sup>CD25<sup>+ </sup>and CD4<sup>+</sup>CD45RO<sup>+ </sup>was higher, while that of CD4<sup>+</sup>CC chemokine receptor (CCR)3<sup>+ </sup>(T helper 2, Th2) was significantly lower in MS patients than in HC. The ratios of CD4<sup>+</sup>CXC chemokine receptors (CXCR)3<sup>+</sup>/CD4<sup>+</sup>CCR3<sup>+ </sup>(Th1/Th2) and CD8<sup>+</sup>CXCR3<sup>+</sup>/CD8<sup>+</sup>CCR4<sup>+ </sup>(T cytotoxic 1, Tc1/Tc2) were higher in MS patients than in HC. The percentage of CD8<sup>+</sup>CXCR3<sup>+ </sup>T cell (Tc1) and CD4<sup>+</sup>CXCR3<sup>+ </sup>T cell (Th1) decreased significantly during remission in MS patients (<it>P <</it>0.05). No significant differences were identified in the expression of the chemokine receptors on PBL in NMO patients compared with MS patients and HC.</p> <p>Conclusions</p> <p>Th1 dominance of chemokine receptors on blood T cells and the correlation between CXCR3<sup>+ </sup>T cell (Th1 and Tc1) and disease activity in MS patients were confirmed by analysing chemokines receptors on PBL. In contrast, deviation in the Th1/Th2 balance was not observed in NMO patients.</p
Gyrofluid simulations of collisionless reconnection in the presence of diamagnetic effects
The effects of the ion Larmor radius on magnetic reconnection are
investigated by means of numerical simulations, with a Hamiltonian gyrofluid
model. In the linear regime, it is found that ion diamagnetic effects decrease
the growth rate of the dominant mode. Increasing ion temperature tends to make
the magnetic islands propagate in the ion diamagnetic drift direction. In the
nonlinear regime, diamagnetic effects reduce the final width of the island.
Unlike the electron density, the guiding center density does not tend to
distribute along separatrices and at high ion temperature, the electrostatic
potential exhibits the superposition of a small scale structure, related to the
electron density, and a large scale structure, related to the ion
guiding-center density
Gyrofluid simulations of collisionless reconnection in the presence of diamagnetic effects
The effects of the ion Larmor radius on magnetic reconnection are
investigated by means of numerical simulations, with a Hamiltonian gyrofluid
model. In the linear regime, it is found that ion diamagnetic effects decrease
the growth rate of the dominant mode. Increasing ion temperature tends to make
the magnetic islands propagate in the ion diamagnetic drift direction. In the
nonlinear regime, diamagnetic effects reduce the final width of the island.
Unlike the electron density, the guiding center density does not tend to
distribute along separatrices and at high ion temperature, the electrostatic
potential exhibits the superposition of a small scale structure, related to the
electron density, and a large scale structure, related to the ion
guiding-center density
Gyrofluid simulations of collisionless reconnection in the presence of diamagnetic effects
The effects of the ion Larmor radius on magnetic reconnection are
investigated by means of numerical simulations, with a Hamiltonian gyrofluid
model. In the linear regime, it is found that ion diamagnetic effects decrease
the growth rate of the dominant mode. Increasing ion temperature tends to make
the magnetic islands propagate in the ion diamagnetic drift direction. In the
nonlinear regime, diamagnetic effects reduce the final width of the island.
Unlike the electron density, the guiding center density does not tend to
distribute along separatrices and at high ion temperature, the electrostatic
potential exhibits the superposition of a small scale structure, related to the
electron density, and a large scale structure, related to the ion
guiding-center density
Measurement of stratospheric and mesospheric winds with a submillimeter wave limb sounder: results from JEM/SMILES and simulation study for SMILES-2
Satellite missions for measuring winds in the troposphere and thermosphere will be launched in a near future. There is no plan to observe winds in the altitude range between 30-90 km, though middle atmospheric winds are recognized as an essential parameter in various atmospheric research areas. Sub-millimetre limb sounders have the capability to fill this altitude gap. In this paper, we summarize the wind retrievals obtained from the Japanese Superconducting Submillimeter Wave Limb Emission Sounder (SMILES) which operated from the International Space Station between September 2009 and April 2010. The results illustrate the potential of such instruments to measure winds. They also show the need of improving the wind representation in the models in the Tropics, and globally in the mesosphere. A wind measurement sensitivity study has been conducted for its successor, SMILES-2, which is being studied in Japan. If it is realized, sub-millimeter and terahertz molecular lines suitable to determine line-of-sight winds will be measured. It is shown that with the current instrument definition, line-of-sight winds can be observed from 20 km up to more than 160 km. Winds can be retrieved with a precision better than 5 m s(-1) and a vertical resolution of 2-3 km between 35-90 km. Above 90 km, the precision is better than 10 m s(-1) with a vertical resolution of 3-5 km. Measurements can be performed day and night with a similar sensitivity. Requirements on observation parameters such as the antenna size, the satellite altitude are discussed. An alternative setting for the spectral bands is examined. The new setting is compatible with the general scientific objectives of the mission and the instrument design. It allows to improve the wind measurement sensitivity between 35 to 90 km by a factor 2. It is also shown that retrievals can be performed with a vertical resolution of 1 km and a precision of 5-10 m s(-1) between 50 and 90 km. RAGAM A, 1953, PHYSICAL REVIEW, V92, P144
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