BIOPROSPECTING OF MUNTINGIA CALABURA: BIOACTIVE COMPOUNDS AND ITS ANTIOXIDANT, ANTIMICROBIAL AND ANTHELMENTHIC ACTIVITY.

Objective: Muntingia calabura is widely cultivated and has become one of the common roadside trees in most parts of the world. The present study aimed to evaluate medicinal property of leaves and fruits of M. calabura, by using antioxidant, antimicrobial and antihelmenthic activities for methanol crude extract.Methods: Standard methods were used to evaluate secondary metabolites in methanol crude extract of leaves and fruits of M. calabura. Total phenolic contents (TPC) were evaluated according to Folin-Ciocalteu method. The free radical quenching ability of extracts were explored by various in vitro assays, such as DPPH, hydroxyl radical scavenging and reducing power assay. Additionally, the antimicrobial and anthelminthic activity was conducted to evaluate the biological efficiency of the plant extract.   Results: Qualitative phytochemical analysis revealed the presence of alkaloids, saponins, tannins, glycosides, flavonoids and phenols. The reduction of free radical content were observed in dose dependent manner in all tested methods for both leaves and fruits methanol extract of the plant. Further, the antimicrobial activity of plant extract indicates the region where tested microorganisms failed to thrive and the methanol extract also showed evidence to have anthelminthic property.Conclusion:  The presence of secondary metabolites and biological activity of methanol crude extract of leaves and fruits of M. calabura ensure the pharmaceutical importance. Â

SLE during pregnancy, maternal and perinatal outcome in teritary hospital

Background: SLE is an autoimmune disease most frequently found in women of child bearing age and may co­exist with pregnancy. Its multisystem involvement and therapeutic interventions pose a high risk for both the mother and the foetus. Disease flares in pregnancy pose challenges with respect to distinguishing physiologic changes related to pregnancy from disease related manifestations. The present study analyzes the fetomaternal outcome of pregnant women with SLE.Methods: An analysis of fetomaternal outcome of pregnant women with SLE during April  2015 to May 2016 at JSS hospital.Results: During the period from April 2016 to May 2016, 3773 deliveries were conducted in the department. Eleven pregnant women with SLE were followed up during this period, giving an incidence of 0.29/1000 deliveries. A high rate of lupus flare during pregnancy was found in the current study. Even among women in remission for more than six months before pregnancy, the rate of lupus flare was not low (27%). Also other complications seen were pre-eclampsia 54.54%, HELLP syndrome in 9.09% , PPH in 50%, polyserositis seen in 9.09% and one maternal death was seen (9.09%). No neonate suffered from heart-blocker however there was 75 % NICU admissions among live borns.Conclusions: Advancing technology and better understanding of the maternal-foetal relationship in lupus have improved outcomes in lupus pregnancies over the last decade. The multisystem nature of the disease, the severity of the organ involvement needs to be assessed and a multidisciplinary approach is required for its diagnosis and successful management

Colposcopic evaluation with modified IFCPC 2011 nomenclature and Swede score for diagnosing premalignant lesions of cervix: a comparative study

Background: Cervical cancer has a long precancerous stage. The early diagnosis in preinvasive stage provides a golden opportunity for prompt intervention to prevent its catastrophic consequences. Through this study we intended to compare the diagnostic accuracy of modified IFCPC 2011 nomenclature and Swede score with respect to gold standard histopathology in colposcopic evaluation of premalignant cervical lesions. Methods: A comparative study was conducted at tertiary care hospital in Delhi, India between January 2021 to June 2022 on 50 women with abnormal Papanicolaou smear (ASCUS, LSIL, ASC-H, HSIL). Scoring of colposcopic lesions was done according to IFCPC nomenclature and Swede’s scoring system. The two colposcopic scores were compared and their statistical association with histological findings were analysed. The collected data was analysed using SPSS version 25. The association of the qualitative variables were analysed using Fischer’s exact test. Agreement was measured by Cohen kappa statistics. Results: Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of modified IFCPC 2011 nomenclature for predicting LSIL and HSIL were 87.50%, 58.82%, 50%, 90.91%, 68% and 100%, 100%, 100%, 100%, 100% respectively. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of swede score for predicting LSIL and HSIL were 87.50%, 41.18%, 41.18%, 87.50%, 56% and 100%, 77.27%, 37.50%, 100%, 80% respectively. Conclusions: Modified IFCPC 2011 nomenclature had better predictive value than swede score in diagnosing both low grade and high grade premalignant lesions of cervix

Traditional method or online teaching; which method students prefer: an observational study

Background: An unexpected global pandemic broke out in initial months of 2020 i.e., COVID-19 which drastically brought a difference in the progress of education in various institutions, especially the medical field where we study about life was also made online. This study aims to conduct a comparative analysis of students ‘opinion regarding which is the better, traditional teaching or online live teaching.Methods: Survey was conducted among two group of students, 2019 (both online and offline teaching) and 2020 (online teaching with offline practical) batches of Andhra Medical College, Visakhapatnam. A questionnaire was circulated to students regarding the class experience, interest of attending the class, learning effect and clarity of the lecture. Results: Students expressed their views that overall teaching experience and learning effect of offline methodology is superior to online approach, so the traditional offline style or the blend of online and offline modes are apt for teaching.Conclusions: The study is focused on the way in which the teaching and learning approach is delivered which is favoured by the medical practitioners, the qualitative data suggesting required modifications for further improvement in the delivering method to produce qualified medical practitioners to meet the current and imminent situations. This study suggests that a intermingled learning approach is an effective method for anatomy learning, and this approach mainly inculcates self-directed study through online learning

Violation of Traffic Rules and Detection of Sign Boards

Today's society has seen a sharp rise in the number of accidents caused by drivers failing to pay attention to traffic signals and regulations. Road accidents are increasing daily as the number of automobiles rises. By using synthesis data for training, which are produced from photos of road traffic signs, we are able to overcome the challenges of traffic sign identification and decrease violations of traffic laws by identifying triple-riding, no-helmet, and accidents, which vary for different nations and locations. This technique is used to create a database of synthetic images that may be used in conjunction with a convolution neural network (CNN) to identify traffic signs, triple riding, no helmet use, and accidents in a variety of view lighting situations. As a result, there will be fewer accidents, and the vehicle operator will be able to concentrate more on continuing to drive but instead of checking each individual road sign. Also, simplifies the process to recognize triple driving, accidents, but also incidents when a helmet was not used

Effect of shade materials on rectal temperature, respiration rate and body surface temperature of crossbred calves during rainy season

An attempt was made to study the effect of different shade materials on body surface temperature, rectal and respiration rate in Vrindavani calves during the rainy season. Crossbred calves (18) were divided into 3 group, viz. thatch shading roof with plastic covering (T1), agro-net shading roof- 60% light diffusion (T2), and asbestos with canvas shading roof (T3). The recording of macro and microclimate as well as the entire physiological parameters, viz. rectal temperature, respiration rate and body surface temperature were recorded at 9:00 and 2:00 PM for 2 consecutive days at every fortnight interval. The microclimate, viz. maximum and minimum, RH, THI and surface temperature of roof was lower in T2 group. The physiological parameters values were significantly lower in T2 group. It can be concluded that in rainy season agro-net helped to protect calves from the hot and humid condition

Effect of different heat ameliorating measures on the micro-climate of buffalo sheds during hot-dry summer

Present investigation studied the effect of heat ameliorating measures on micro-climate of sheds of Murrah buffalo heifers during hot dry summer. Buffalo heifers (24) were categorised in 4 groups (6 in each), viz. control (T0), cooling jacket (T1), cooling jacket+forced ventilation (T2) and sprinklers+forced ventilation (T3). Daily minimum and maximum and dry and wet bulb temperatures of both micro and macro-climate were measured at 10.00 AM and 2.00 PM of Indian Standard Time (IST) by using maximum and minimum and dry and wet bulb thermometer, respectively. Significant reduction in maximum temperature was observed in T3, T2 and T1 groups than control group. However, significantly higher minimum temperature was found in T0 group as compared to T3, T2 and T1 respectively. Relative humidity (RH) was significantly lower in T3 and T2 (65.67±0.48 and 65.97±0.53%, respectively) than T0 (68.51±0.56%) group at 10.00 AM whereas, at 2.00 PM significant reduction in RH was observed in T3, and T2 (55.31±0.51 and 57.20±0.62) than T0 (58.96±0.63%) group. During peak hot periods, significantly lower Temperature humidity Index (THI) was found in T3, T2 and T1 than T0 group. However, at 10.00 AM significant reduction in THI was found in T3 and T2 groups than T0 group. The findings of the present study indicated that forced ventilation along with sprinklers and cooling jacket had helped in protecting the animals from thermal stress under loose housing system during hot-dry summer

Proof-of-Principle Experiment for FEL-Based Coherent Electron Cooling,”

Abstract Coherent electron cooling (CEC) has a potential to significantly boost luminosity of high-energy, highintensity hadron-hadron and electron-hadron colliders. In a CEC system, a hadron beam interacts with a cooling electron beam. A perturbation of the electron density caused by ions is amplified and fed back to the ions to reduce the energy spread and the emittance of the ion beam. To demonstrate the feasibility of CEC we propose a proof-of-principle experiment at RHIC using SRF linac. In this paper, we describe the setup for CeC installed into one of RHIC's interaction regions. We present results of analytical estimates and results of initial simulations of cooling a gold-ion beam at 40 GeV/u energy via CeC

A Study of Quality of Work Life of Nationalized and Non Nationalized Bank Employees

The objective of the present study is to determine scientifically the level of quality-of-work-life (QWL) of nationalized and non-nationalized bank employees and also to find out the significance of difference between nationalized and non-nationalized bank employees in their QWL. To achieve this objective, The Quality of Work Life-Condition/ Feelings form was administered on a sample of 78 bank employees of which 39 are from nationalized and 39 from non-nationalized banks in Hubli—Dhaiwad Corporation area. The obtained responses were scored and subjected to t-test. The results revealed that the nationalized bank employees have significantly higher QWL than those of non-nationalized bank employees in the dimensions like- autonomy, Work speed and Routine, Work complexity as well as the composite QWL—Conditions. The incidental analyses in the study revealed that the bank employees who expressed higher life satisfaction have shown significantly higher QWL with regard to conditions than those who expressed moderate life satisfaction

<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Neuropharmcological potential of methanolic extract and a triterpene isolated from <i>Madhuca longifolia L</i> leaves in mice </span>

862-866The methanolic extract of M. longifolia (MLME) and a compound a triterpene, derivative of madhucic acid (dMA) isolated from the leaves of M. longifolia, were investigated for their possible neuropharmacological activities in mice using phenobarbitone induced sleeping time, spontaneous motor activity, marble burying test and Eddy’s hot plate method. LD50 for MLME and dMA were 100 and 10 mg/kg of body weight, respectively. Both MLME and dMA (10 mg/kg and 2 mg/kg oral route respectively) exhibited significant increase in phenobarbitone induced sleeping time, greater reduction in spontaneous motor activity and marble burying activity, confirming their sedative nature. Both MLME and dMA also exhibited considerable antinociceptive activity in experimental animals. The results suggest that both MLME and dMA have CNS depressant activity in mice