Analysis of Yield Criteria and Flow Curves on FLC for TWIP900 Steel

In this study, the applicability of yield criteria and flow curve models to predict forming limit curve (FLC) via the Marciniak-Kuczynski (M-K) model is investigated for TWIP900 steel. Forming limit characteristics of TWIP900 are determined experimentally and numerically. The yield criteria of Hill48, Barlat89, YLD2000-2d, and BBC2000 are tested and compared with each other. Results indicate that the YLD2000-2d and the BBC2000 yield criteria are found to be more accurate than the other criteria. The YLD2000 criterion has the best prediction capability with the Krupskowsky flow curve while the BBC2000 model has the best prediction with the Ludwick flow curve model. © 2020, The Society for Experimental Mechanics, Inc

Creating atom-nanoparticle quantum superpositions

A nanoscale object evidenced in a nonclassical state of its center of mass will hugely extend the boundaries of quantum mechanics. To obtain a practical scheme for the same, we exploit a hitherto unexplored coupled system: an atom and a nanoparticle coupled by an optical field. We show how to control the center of mass of a large ∼ 500 -nm nanoparticle using the internal state of the atom so as to create, as well as detect, nonclassical motional states of the nanoparticle. Specifically, we consider a setup based on a silica nanoparticle coupled to a cesium atom and discuss a protocol for preparing and verifying a Schrödinger-cat state of the nanoparticle that does not require cooling to the motional ground state. We show that the existence of the superposition can be revealed using the Earth's gravitational field using a method that is insensitive to the most common sources of decoherence and works for any initial state of the nanoparticle

Protective effect of Coriandrum sativum extract against inflammation and apoptosis in liver ischaemia/reperfusion injury

Background: The aim of this study was to investigate the anti-inflammatory and antioxidant effects of Coriandrum sativum extract on liver ischaemia reperfusion injury at light microscopic and biochemical levels. Materials and methods: Sham, ischaemia/reperfusion injury (IRI), IRI + Coriandrum sativum extract and only Coriandrum sativum extract groups were formed. Sixty minutes of ischaemia and 60 minutes of reperfusion were performed. In the treatment group, 300 mg/kg/day Coriandrum sativum was given by gavage. Hepatic tissues were fixed in 4% paraformaldehyde. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) enzymes were measured. Nuclear factor-kappa beta (NF-κB), tumour necrosis factor-alpha (TNF-α) and caspase-3 immunohistochemistry staining was performed. Microscopic scoring was performed in terms of sinusoidal congestion, vacuolisation, and necrosis. Results: Sinusoidal enlargement and diffuse congestion, Kupffer cell increase, neutrophil increase in necrotic areas, vacuolisation in hepatocytes, and bile duct proliferation in the portal triad were observed in ischaemia/reperfusion hepatic tissue. Very rare, necrotic areas were observed in the Coriandrum sativum treatment group, while congestion and vacuolisation and bile duct proliferation were decreased compared to the ischaemic group. The AST and ALT levels were increased in the IRI and IRI + Coriandrum sativum groups. When compared to the IRI group, the AST and ALT levels of the Coriandrum sativum were considerably decreased. The IRI and IRI + Coriandrum sativum groups had statistically significant differences in ALP compared to that of the Coriandrum sativum and Sham groups. There was no significant difference between the ALP levels of the IRI and IRI + Coriandrum sativum groups TNF-α, NF-κB and caspase-3 immune positive stained hepatocytes were numerous and widely observed in the injury group. There were positive TNF-α immunohistochemical staining Kupffer cells in the IRI group. In the group treated with Coriandrum sativum, Kupffer cells were not stained, while TNF-α, NF κB and caspase-3 expressing hepatocytes were found to be decreased compared to the IRI group. When the expression values of the TNF-α, NF-κB and caspase-3 groups were evaluated statistically, it was seen that there was a significant decrease in the group treated with Coriandrum sativum. Conclusions: It was found that Coriandrum sativum extract decreased proinflammatory cytokine TNF-α and apoptotic cell death and liver enzymes in liver ischaemia/reperfusion injury

Coherent-scattering two-dimensional cooling in levitated cavity optomechanics

The strong light-matter optomechanical coupling offered by coherent scattering set-ups have allowed the experimental realization of quantum ground-state cavity cooling of the axial motion of a levitated nanoparticle [U. Delić et al., Science 367, 892 (2020)]. An appealing milestone is now quantum two-dimensional (2D) cooling of the full in-plane motion, in any direction in the transverse plane. By a simple adjustment of the trap polarization, one obtains two nearly equivalent modes, with similar frequencies ω x ∼ ω y and optomechanical couplings g x ≃ g y —in this experimental configuration we identify an optimal trap ellipticity, nanosphere size, and cavity linewidth which allows for efficient 2D cooling. Moreover, we find that 2D cooling to occupancies n x + n y ≲ 1 at moderate vacuum ( 10 − 6 mbar) is possible in a “Goldilocks” zone bounded by √ κ Γ / 4 ≲ g x , g y ≲ ∣ ∣ ω x − ω y ∣ ∣ ≲ κ , where one balances the need to suppress dark modes while avoiding far-detuning of either mode or low cooperativities, and κ ( Γ ) is the cavity decay rate (motional heating rate). With strong-coupling regimes g x , g y ≳ κ in view one must consider the genuine three-way hybridization between x , y and the cavity light mode resulting in hybridized bright/dark modes. Finally, we show that bright/dark modes in the levitated set-up have a simple geometrical interpretation, related by rotations in the transverse plane, with implications for directional sensing

Genomic amplifications identified by circulating tumor DNA analysis guide prognosis in metastatic castration-resistant prostate cancer

PurposeAnalysis of circulating tumor DNA (ctDNA) in patients with metastatic prostate cancer (mPC) provides an opportunity to identify and monitor genomic alterations during a patient’s treatment course. We evaluated whether the presence of specific gene amplifications (GAs) and plasma copy number (PCN) alterations are associated with disease features.MethodsThis is a single-institution retrospective study of patients with mPC who underwent ctDNA profiling using Guardant360® (Guardant Health Inc.). This test identifies single nucleotide variants (SNVs) and GAs of select genes by next-generation sequencing. A total of 155 men with mPC were studied. Patients were stratified by GA status. The Kaplan-Meier method and multivariate cox regression models were used to estimate overall survival (OS) or failure-free survival (FFS) from either the date of GA detection or the initiation of systemic therapy. The chi-square test was used to evaluate associations between clinical factors and GAs. ResultsThe presence of liver and/or lung metastases was associated with GAs of BRAF, CDK6, PI3KCA, and FGFR1. Survival analyses were completed on a subset of 83 patients with metastatic castration-resistant prostate cancer (mCRPC). Median OS was improved in patients with 1 GA compared to patients with ≥2 GAs, whether determined from the date of initial GA(s) detection (14.9 mo vs. 8.9 mo) or date of therapy initiation nearest to GA detection (16.7 mo vs. 9.0 mo). Patients without GAs had not reached median OS. Patients with androgen receptor (AR) GA only were also found to have better median OS compared to patients with AR GA plus at least one other additional GA (19.3 mo vs. 8.9 mo). Patients with PIK3CA GA had significantly lower median OS compared to patients with GAs that did not have a PIK3CA GA (5.9 mo vs. 16.0 mo). In patients with AR and/or MYC GA(s), median OS improved in those with reduced AR or MYC PCN during therapy compared to those without such a reduction (25.1 mo vs. 15.9 mo). ConclusionsThe association of select GAs with survival provides an additional tool for assessing mCRPC prognosis and informing management. Serial monitoring of ctDNA GAs is also useful to guide prognosis and therapeutic response

Reclaiming the political : emancipation and critique in security studies

The critical security studies literature has been marked by a shared commitment towards the politicization of security – that is, the analysis of its assumptions, implications and the practices through which it is (re)produced. In recent years, however, politicization has been accompanied by a tendency to conceive security as connected with a logic of exclusion, totalization and even violence. This has resulted in an imbalanced politicization that weakens critique. Seeking to tackle this situation, the present article engages with contributions that have advanced emancipatory versions of security. Starting with, but going beyond, the so-called Aberystwyth School of security studies, the argument reconsiders the meaning of security as emancipation by making the case for a systematic engagement with the notions of reality and power. This revised version of security as emancipation strengthens critique by addressing political dimensions that have been underplayed in the critical security literature

Renal and suprarenal insufficiency secondary to familial Mediterranean fever associated with amyloidosis: a case report

<p>Abstract</p> <p>Introduction</p> <p>Familial Mediterranean fever is an autosomal recessive disease that predominantly affects people of the Mediterranean coast. One of the most frequent complications of the disease is amyloidosis. This clinical entity is known as secondary (also called AA) amyloidosis.</p> <p>Case presentation</p> <p>In this report, we describe the case of a 33-year-old Turkish man with familial Mediterranean fever and chronic renal insufficiency. He was admitted to our clinic with symptoms of suprarenal insufficiency. The patient died three months later as a result of cardiac arrest.</p> <p>Conclusion</p> <p>Our aim is to make a contribution to the literature by reporting a case of combined insufficiency due to the accumulation of renal and adrenal amyloid in a patient with familial Mediterranean fever, which has very rarely been described in the literature. We hope that adrenal insufficiency, which becomes fatal if not diagnosed and treated rapidly, will come to mind as easily as chronic renal failure in clinical practice.</p