24 research outputs found
Pioglitazone/metformin adduct regulates insulin secretion and inhibits high glucose‐induced apoptosis via p21‐p53‐MDM2 signaling in INS‐1 cells
Metabolic surgery for the treatment of type 2 diabetes in patients with BMI <35kg/m2: an integrative review of early studies.
Type 2 diabetes mellitus (T2DM) resolution in morbidly obese patients following
metabolic surgery suggests the efficacy of T2DM surgery in non-morbidly obese
patients (body mass index [BMI] <35 kg/m(2)). This literature review examined
research articles in English over the last 30 years (1979-2009) that addressed
surgical resolution of T2DM in patients with a mean BMI <35. Weighted and simple
means (95% CI) were calculated to analyze study outcomes. Sixteen studies met
inclusion criteria; 343 patients underwent one of eight procedures with 6-216
months follow-up. Patients lost a clinically meaningful, not excessive, amount of
weight (from BMI 29.4 to 24.2; -5.1), moving from the overweight into the normal
weight category. There were 85.3% patients who were off T2DM medications with
fasting plasma glucose approaching normal (105.2 mg/dL, -93.3), and normal
glycated hemoglobin, 6% (-2.7). In subgroup comparison, BMI reduction and T2DM
resolution were greatest following malabsorptive/restrictive procedures, and in
the preoperatively mildly obese (30.0-35.0) vs overweight (25.0-25.9) BMI ranges.
Complications were few with low operative mortality (0.29%). Novel and/or known
mechanisms of T2DM resolution may be engaged by surgery at a BMI threshold
<or=30. The majority of low-BMI patients experienced resolution of laboratory and
clinical manifestations of T2DM without inappropriate weight loss
Effects of isolated or combined exposure to sibutramine and rosuvastatin on reproductive parameters of adult male rats
Quasi-Static Characteristics of a Two-Conductor Multi-Layer Microstrip Transmission Line with Dielectric Overlay and a Notch between the Strips
The Effect of Very-Low-Calorie Diet on mRNA Expression of Inflammation-Related Genes in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Patients with Type 2 Diabetes Mellitus
Alien Registration- Tompkins, Reginald (Norway, Oxford County)
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