Using Evaluation to Foster NYCETP Goals: Case Studies and Intercampsus Collaboration

This article describes the use of case studies as part of the formative evaluation conducted for the New York Collaborative for Excellence in Teacher Preparation (NYCETP). While case studies are often conducted for evaluations by outside experts, consultants, or evaluators themselves, we developed a strategy for case studies that used NYCETP faculty to case-study each other. This strategy involved cross-campus collaboration and cross-discipline (Arts & Science and Education) collaboration, and thus actively supported one of the NYCETP goals. The case study strategy also included the development of a faculty (peer) review form for evaluation of documentation of new and revised courses. Procedures for case studies and examples of case study benefits for faculty and evaluators are also described

Coherent Description for Hitherto Unexplained Radioactivities by Super- and Hyperdeformed Isomeric States

Recently long-lived high spin super- and hyperdeformed isomeric states with unusual radioactive decay properties have been discovered. Based on these newly observed modes of radioactive decay, consistent interpretations are suggested for previously unexplained phenomena seen in nature. These are the Po halos, the low-energy enhanced 4.5 MeV alpha-particle group proposed to be due to an isotope of a superheavy element with Z = 108, and the giant halos.Comment: 8 pages, 2 figures, 1 table, to be published in Int. J. Mod. Phys.

Super- and Hyperdeformed Isomeric States and Long-Lived Superheavy Elements

The recent discoveries of the long-lived high spin super- and hyperdeformed isomeric states and their unusual radioactive decay properties are described. Based on their existence a consistent interpretation is given to the production of the long-lived superheavy element with Z = 112, via secondary reactions in CERN W targets, and to the low energy and very enhanced alpha-particle groups seen in various actinide fractions separated from the same W target. In addition, consistent interpretations are suggested for previously unexplained phenomena seen in nature. These are the Po halos, the low-energy enhanced 4.5 MeV alpha-particle group proposed to be due to an isotope of a superheavy element with Z = 108, and the giant halos.Comment: 4 pages. Contribution to the 2nd Int. Conf. on the Chemistry and Physics of the Transactinide Elements (TAN 03) Napa California, November 200

Improving the sensitivity of stop searches with on-shell constrained invariant mass variables

The search for light stops is of paramount importance, both in general as a promising path to the discovery of beyond the standard model physics and more specifically as a way of evaluating the success of the naturalness paradigm. While the LHC experiments have ruled out much of the relevant parameter space, there are "stop gaps", i.e., values of sparticle masses for which existing LHC analyses have relatively little sensitivity to light stops. We point out that techniques involving on-shell constrained M_2 variables can do much to enhance sensitivity in this region and hence help close the stop gaps. We demonstrate the use of these variables for several benchmark points and describe the effect of realistic complications, such as detector effects and combinatorial backgrounds, in order to provide a useful toolkit for light stop searches in particular, and new physics searches at the LHC in general.Comment: 49 pages, 28 figures, revised version published in JHEP, references adde

On-shell constrained M2M_2 variables with applications to mass measurements and topology disambiguation

We consider a class of on-shell constrained mass variables that are 3+1 dimensional generalizations of the Cambridge $M_{T2}$ variable and that automatically incorporate various assumptions about the underlying event topology. The presence of additional on-shell constraints causes their kinematic distributions to exhibit sharper endpoints than the usual $M_{T2}$ distribution. We study the mathematical properties of these new variables, e.g., the uniqueness of the solution selected by the minimization over the invisible particle 4-momenta. We then use this solution to reconstruct the masses of various particles along the decay chain. We propose several tests for validating the assumed event topology in missing energy events from new physics. The tests are able to determine: 1) whether the decays in the event are two-body or three-body, 2) if the decay is two-body, whether the intermediate resonances in the two decay chains are the same, and 3) the exact sequence in which the visible particles are emitted from each decay chain.Comment: 44pages, 17 figures. revised version, published in JHEP. Minor addition: a paragraph discussing the effect on the background at the end of section 5.

Natural similarity measures between position frequency matrices with an application to clustering

Motivation: Transcription factors (TFs) play a key role in gene regulation by binding to target sequences. In silico prediction of potential binding of a TF to a binding site is a well-studied problem in computational biology. The binding sites for one TF are represented by a position frequency matrix (PFM). The discovery of new PFMs requires the comparison to known PFMs to avoid redundancies. In general, two PFMs are similar if they occur at overlapping positions under a null model. Still, most existing methods compute similarity according to probabilistic distances of the PFMs. Here we propose a natural similarity measure based on the asymptotic covariance between the number of PFM hits incorporating both strands. Furthermore, we introduce a second measure based on the same idea to cluster a set of the Jaspar PFMs. Results: We show that the asymptotic covariance can be efficiently computed by a two dimensional convolution of the score distributions. The asymptotic covariance approach shows strong correlation with simulated data. It outperforms three alternative methods. The Jaspar clustering yields distinct groups of TFs of the same class. Furthermore, a representative PFM is given for each class. In contrast to most other clustering methods, PFMs with low similarity automatically remain singletons. Availability: A website to compute the similarity and to perform clustering, the source code and Supplementary Material are available at http://mosta.molgen.mpg.d

OPTIMASS: A Package for the Minimization of Kinematic Mass Functions with Constraints

Reconstructed mass variables, such as $M_2$, $M_{2C}$, $M_T^\star$, and $M_{T2}^W$, play an essential role in searches for new physics at hadron colliders. The calculation of these variables generally involves constrained minimization in a large parameter space, which is numerically challenging. We provide a C++ code, OPTIMASS, which interfaces with the MINUIT library to perform this constrained minimization using the Augmented Lagrangian Method. The code can be applied to arbitrarily general event topologies and thus allows the user to significantly extend the existing set of kinematic variables. We describe this code and its physics motivation, and demonstrate its use in the analysis of the fully leptonic decay of pair-produced top quarks using the $M_2$ variables.Comment: 39 pages, 12 figures, (1) minor revision in section 3, (2) figure added in section 4.3, (3) reference added and (4) matched with published versio

Neuromuscular Blockade with Rocuronium Bromide Increases the Tolerance of Acute Normovolemic Anemia in Anesthetized Pigs

Background: The patient's individual anemia tolerance is pivotal when blood transfusions become necessary, but are not feasible for some reason. To date, the effects of neuromuscular blockade (NMB) on anemia tolerance have not been investigated. Methods: 14 anesthetized and mechanically ventilated pigs were randomly assigned to the Roc group (3.78 mg/kg rocuronium bromide followed by continuous infusion of 1 mg/kg/min, n = 7) or to the Sal group (administration of the corresponding volume of normal saline, n = 7). Subsequently, acute normovolemic anemia was induced by simultaneous exchange of whole blood for a 6% hydroxyethyl starch solution (130/0.4) until a sudden decrease of total body O-2 consumption (VO2) indicated a critical limitation of O-2 transport capacity. The Hb concentration quantified at this time point (Hb(crit)) was the primary end-point of the protocol. Secondary endpoints were parameters of hemodynamics, O-2 transport and tissue oxygenation. Results: Hb(crit) was significantly lower in the Roc group (2.4 +/- 0.5 vs. 3.2 +/- 0.7 g/dl) reflecting increased anemia tolerance. NMB with rocuronium bromide reduced skeletal muscular VO2 and total body O-2 extraction rate. As the cardiac index increased simultaneously, total body VO2 only decreased marginally in the Roc group (change of VO2 relative to baseline -1.7 +/- 0.8 vs. 3.2 +/- 1.9% in the Sal group, p < 0.05). Conclusion: Deep NMB with rocuronium bromide increases the tolerance of acute normovolemic anemia. The underlying mechanism most likely involves a reduction of skeletal muscular VO2. During acellular treatment of an acute blood loss, NMB might play an adjuvant role in situations where profound stages of normovolemic anemia have to be tolerated (e.g. bridging an unexpected blood loss until blood products become available for transfusion). Copyright (C) 2011 S. Karger AG, Base

Autonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system.

Bioluminescence-based imaging of living cells has become an important tool in biological and medical research. However, many bioluminescence imaging applications are limited by the requirement of an externally provided luciferin substrate and the low bioluminescence signal which restricts the sensitivity and spatiotemporal resolution. The bacterial bioluminescence system is fully genetically encodable and hence produces autonomous bioluminescence without an external luciferin, but its brightness in cell types other than bacteria has, so far, not been sufficient for imaging single cells. We coexpressed codon-optimized forms of the bacterial luxCDABE and frp genes from multiple plasmids in different mammalian cell lines. Our approach produces high luminescence levels that are comparable to firefly luciferase, thus enabling autonomous bioluminescence microscopy of mammalian cells