21 research outputs found
Biodegradation of alpha- and beta-hexachlorocyclohexane in a soil slurry under different redox conditions
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Inhibition of solution-processed 1,4,5,8,9,11-hexaazatriphenylene-hexacarbonitrile crystallization by mixing additives for hole injection layers in organic light-emitting devices
No full textMolecular cloning of a Pseudomonas paucimobilis gene encoding a 17-kilodalton polypeptide that eliminates HCl molecules from gamma-hexachlorocyclohexane
No full textThermally Cross-Linkable Hole Transport Materials for Solution Processed Phosphorescent OLEDs
No full textEffect of Substrate Concentration and Organic and Inorganic Compounds on the Occurrence and Rate of Mineralization and Cometabolism
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Ubiquitin-dependent regulation of COPII coat size and function
No full textPackaging of proteins from the ER into COPII-vesicles is essential for secretion. In cells, most COPII-vesicles are ~60-80nm in diameter, yet some must increase their size to accommodate 300-400nm procollagen fibers or chylomicrons. Impaired COPII function results in collagen deposition defects, cranio-lenticulo-sutural dysplasia, or chylomicron retention disease, but mechanisms to enlarge COPII-coats have remained elusive. Here, we have identified the ubiquitin ligase Cul3(Klhl12) as a regulator of COPII coat formation. Cul3(Klhl12) catalyzes the monoubiquitination of the COPII-component Sec31 and drives the assembly of large COPII coats. As a result, ubiquitination by Cul3(Klhl12) is essential for collagen export, yet less important for the transport of small cargo. We conclude that monoubiquitination controls the size and function of a vesicle coat
