Comparison of maternal satisfaction following epidulral and general anaesthesia for repeat caesarean section

Objective: To assess maternal satisfaction following two anaesthetic techniques (general and epidural anaesthesia) for repeat Caesarean section.Design: Prospective study.Setting: University of Port Harcourt Teaching Hospital, Nigeria.Subjects: One hundred and twenty parturients scheduled for elective Caesarean section.Results: The demographic data and mean satisfaction scores obtained from questionnaire and visual analogue scale (VAS) were subjected to analysis using the Student’s t-test with the computerised statistical calculator SPSS Windows 10.0. The mean satisfaction score of the parturients in the epidural anaesthesia population using the questionnaire was 149.0±10.65 while that in the general anaesthesia population was 105.3±12.42. The mean satisfaction score from the VAS was 9.0±1.50 for those who had epidural anaesthesia while it was 2.6±0.70 in the general anaesthesia population. The differences in the mean satisfaction scores from both instruments of measurement were statistically significant at

The oncological and reproductive outcomes of fertility-preserving treatments for stage 1 grade 1 endometrial carcinoma: a systematic review and meta-analysis.

INTRODUCTION: The number of patients desiring fertility-preserving treatment for endometrial cancer rather than standard surgical management continues to increase. OBJECTIVE: We aimed to evaluate the efficacies of fertility-preserving treatments on the live birth rate, remission and relapse rates for women with stage 1a grade 1 endometrial carcinoma to support patient counselling. METHODS: We performed a meta-analysis for our primary outcomes of overall remission and relapse rate, and for secondary analysis, we divided papers into treatment type: systemic progestins, intrauterine progestins or hysteroscopic resection and adjuvant hormonal treatment. RESULTS: Thirty-five observational studies met inclusion criteria, with a total of 624 patients. Overall, conservative treatment of endometrial cancer showed a remission rate of 77% (95% CI: 70-84%), a relapse rate of 20% (95% CI: 13-27%) and a live birth rate of 20% (95% CI: 15-25%) with more favourable outcomes for the hysteroscopic resection group. CONCLUSIONS: Hysteroscopic resection and adjuvant hormonal treatment had the most favourable fertility and oncological outcomes. Further high-quality prospective multi-centre trials are warranted to determine the optimal treatment regimen and dosage and risk stratification for these patients

The Potential for Wolbachia-Based Mosquito Biocontrol Strategies in Africa

The three foremost medically important mosquito species of public health importance belong to the genera Anopheles, Aedes, and Culex. The Anopheles mosquito is the most important in the transmission of human malaria, while members of the genera Culex and Aedes are more important in the transmission of arboviruses. Reducing the number of competent vectors has been identified as a logical method for the control of malarial and arboviral vector-borne diseases. This chapter provides an update on the potentials of biological vector control, specifically the release of endosymbionts to help limit the reproductive capability of mosquitoes, thereby reducing the population of the disease vectors in Africa. There are examples of successful suppression of mosquito-borne diseases by the establishment of Wolbachia in mosquito populations elsewhere, however, there has been no such report from the African continent. Although the establishment of stable maternally transmissible Wolbachia in natural mosquito populations is yet to be achieved in Africa, this area of research is experiencing unprecedented progress within the past decade. Many of the research efforts are hereby highlighted, including the problems and prospects of establishing a Wolbachia-based biocontrol program in Africa

Experimental Investigation of Hydrodynamic Slug Flow in Pipeline-Riser Systems

Activities in oil and gas industry have shifted deep offshore. There is therefore the need to envisage and accurately provide for flow assurance challenges that might be encountered throughout the life of a field. Slug flow is one of the flow assurance concerns confronting the industry. The objective of the study was to gain insight into the behaviour of hydrodynamic slug flow in pipeline-riser system. This understanding is needed for the development of appropriate slug control strategy. Experimental studi es were conducted in a 2” pipeline-riser system and a 2” horizontal two -phase flow facility. Slug envelopes were developed for the pipeline-riser system, the vertical and the horizontal pipes. The results revealed three distinct slug flow behaviours. The first type of slug was formed in the horizontal pipeline and transported through the riser pipe nearly unchanged, the second type of slugs were formed in the horizontal pipe but also experience growth in the riser pipe while the third are slugs formed in the vertical pipe without the influence of the upstream horizontal pipe. There is therefore the need to develop appropriate slug control strategies based on the observed behaviour of the identified region

Design and Construction of an Arduino - Based Solar Power Parameter-Measuring System with Data Logger

Accurate monitoring and measurement of solar photovoltaic panel parameters are important for solar power plant analysis to evaluate the performance and predict the future energy generation. There are always challenges of getting such data readily available due to huge amount of money to be spent on state of the art equipment or the purchase of reliable satellite weather data. This study aimed at the development of a cost-effective parameter-measuring system for a solar photovoltaic panel using Arduino microprocessor board. The systems measure five parameters, including voltage, current, light intensity, temperature, and pressure. The hardware circuit was designed to link different sensors with the Arduino board and the measured data were in turn were documented into a computer for further analysis. The accuracy of the constructed device was ascertained by comparing the measured parameters with that of conventional standard measuring instruments which shows good agreement. The measured parameters show that the output energy generation from solar photovoltaic panel largely depends on the solar irradiance and temperatur

Production of Biodiesel from Soybean Oil Using Calcium Oxide and Cow Bone as Catalysts

Biodiesel was produced from the transesterification of soybean oil using calcium oxide and cow bone (an animal waste bone that contains hydroxyapatite, a calcium phosphate mineral) as heterogeneous catalysts. The soybean oil used was characterized using gas chromatography mass spectrometer (GCMS) and the cow bone catalyst produced was characterized using X-ray diffractometer (XRD) and X-ray fluorescence (XRF) spectrometer. The effects of the variation of methanol/oil mole ratio (9–15), catalyst concentration (10–20 wt/wt%) and reaction temperature (55–65 °C) on biodiesel yield during the transesterification of soybean oil with methanol was investigated. Reaction time of 3 hours and stirring rate of 500 rpm were kept constant. It was observed that the calcination of cow bone catalyst (at 800 °C) enhanced its conversion to apatite [Ca5(PO4)3OH] and increased the yield of biodiesel obtained. Biodiesel yield results revealed an optimum condition of methanol/oil mole ratio of 9, catalyst concentration of 15 wt/wt% and reaction temperature of 55 °C. Also, the results obtained showed that the performance trends of the two catalysts used were similar. And the close values of highest biodiesel yields obtained when the two heterogenous catalysts were used separately (yields of 94.8 and 92.2% using calcium oxide and calcined cow bone catalysts respectively) implies that the use of low-cost and readily available calcined cow bone catalyst is a promising alternative to CaO catalyst

Clinicopathological correlations of mesenteric fibrosis and evaluation of a novel biomarker for fibrosis detection in small bowel neuroendocrine neoplasms

PURPOSE: Mesenteric fibrosis (MF) in small intestinal neuroendocrine neoplasms (SINENs) is often associated with significant morbidity and mortality. The detection of MF is usually based on radiological criteria, but no previous studies have attempted a prospective, multidimensional assessment of mesenteric desmoplasia to determine the accuracy of radiological measurements. There is also a lack of non-invasive biomarkers for the detection of image-negative MF. METHODS: A multidimensional assessment of MF incorporating radiological, surgical and histological parameters was performed in a prospective cohort of 34 patients with SINENs who underwent primary resection. Pre-operative blood samples were collected in 20 cases to evaluate a set of five profibrotic circulating transcripts-the "fibrosome"-that is included as an "omic" component of the NETest. RESULTS: There was a significant correlation between radiological and surgical assessments of MF (p < 0.05). However, there were several cases of image-negative MF. The NETest-fibrosome demonstrated an accuracy of 100% for the detection of microscopic MF. CONCLUSIONS: The detection of MF by radiological criteria has limitations. The NETest-fibrosome is a promising biomarker for fibrosis detection and further validation of these results would be needed in larger, multicentre studies

COVID-19 and vertical transmission: assessing the expression of ACE2 / TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection

Background: While pregnant women have been identified as a potentially at-risk group concerning COVID-19 infection, little is known regarding the susceptibility of the fetus to infection. Co-expression of ACE2 and TMPRSS2 has been identified as a pre-requisite for infection, and expression across different tissues is known to vary between children and adults. However, the expression of these proteins in the fetus is unknown. Methods: We performed a retrospective analysis of single cell data repositories. This data was then validated at both gene and protein level by performing qRT-PCR and two-colour immunohistochemistry on a library of second-trimester human fetal tissues. Findings: TMPRSS2 is present at both gene and protein level in the predominantly epithelial fetal tissues analysed. ACE2 is present at significant levels, only in the fetal intestine and kidney and is not expressed in the fetal lung. The placenta is also negative for the two proteins both during development and at term. Interpretation: This dataset indicates that the lungs are unlikely to be a viable route of SARS-CoV2 fetal infection. The fetal kidney, despite presenting both the proteins required for the infection, is anatomically protected from the exposure to the virus. However, the GI tract is likely to be susceptible to infection due to its high co-expression of both proteins, as well as its exposure to potentially infected amniotic fluid